Management of Diffuse Carcinomatosis of the Bone Marrow from Occult Breast Cancer with Abemaciclib and Letrozole: Case Report and Literature Review
Occult breast cancer (OBC) signifies a rare subset of breast cancers, accounting for only 0.3 to 1% of all breast cancers. Diagnosing cancer of unknown primary requires a comprehensive approach, including histological examination, immunohistochemistry, multidisciplinary team assessments, and special...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
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| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1787710 |
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| Summary: | Occult breast cancer (OBC) signifies a rare subset of breast cancers, accounting for only 0.3 to 1% of all breast cancers. Diagnosing cancer of unknown primary requires a comprehensive approach, including histological examination, immunohistochemistry, multidisciplinary team assessments, and specialized therapy. We present the case of a postmenopausal woman diagnosed with OBC with diffuse carcinomatosis of the bone marrow (DCBM), which was hormone receptor positive and Her2neu negative. Treatment with aromatase inhibitor and the cyclin-dependent kinase 4/6 (CDK4/6) inhibitor abemaciclib yielded significant clinical improvement. The full potential of this therapy warrants investigation in real-world studies. |
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| ISSN: | 0971-5851 0975-2129 |