Comparing cardiac radiation dose between accelerated partial breast irradiation and whole breast irradiation: A narrative review
Breast-conserving surgery with whole breast irradiation (WBI) is the standard of care for early-stage breast cancer which provides similar local control and survival outcomes to mastectomy alone. Advances in radiation therapy (RT), such as hypofractionated RT and accelerated partial breast irradiati...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-07-01
|
| Series: | Annals of Oncology Research and Therapy |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/aort.aort_45_24 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849426395346763776 |
|---|---|
| author | Alexis N. Reinders Eilidh M. O’Brien Gregory Mark Hermann |
| author_facet | Alexis N. Reinders Eilidh M. O’Brien Gregory Mark Hermann |
| author_sort | Alexis N. Reinders |
| collection | DOAJ |
| description | Breast-conserving surgery with whole breast irradiation (WBI) is the standard of care for early-stage breast cancer which provides similar local control and survival outcomes to mastectomy alone. Advances in radiation therapy (RT), such as hypofractionated RT and accelerated partial breast irradiation (APBI), have demonstrated equivalent cancer control with the benefit of lower cardiac exposure. We conducted a comprehensive literature search from May 2024 to July 2024, focusing on search terms related to breast irradiation and cardiac toxicity. We reviewed and included 34 articles on cardiac dosing (i.e., mean heart dose and left anterior descending (LAD) coronary artery dose). The purpose of our study was to review the current literature on cardiac dosing in breast cancer patients with a focus on comparing the cardiac toxicity of WBI versus APBI. APBI is noninferior to WBI with regard to local recurrence, although APBI techniques differ in their efficacy. Notably, most APBI techniques display superiority with regard to reducing cardiac toxicity. Additional studies are needed to compare cardiac toxicity between APBI techniques and the long-term effects of APBI versus WBI. In conclusion, compared to WBI, APBI provides notable benefits, such as reduced heart radiation exposure and long-term coronary event risks while offering a more convenient and accessible treatment schedule. |
| format | Article |
| id | doaj-art-ff94714ada2d4e899d85cce424abf9eb |
| institution | Kabale University |
| issn | 2772-8382 2772-8390 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Oncology Research and Therapy |
| spelling | doaj-art-ff94714ada2d4e899d85cce424abf9eb2025-08-20T03:29:26ZengWolters Kluwer Medknow PublicationsAnnals of Oncology Research and Therapy2772-83822772-83902025-07-0152869310.4103/aort.aort_45_24Comparing cardiac radiation dose between accelerated partial breast irradiation and whole breast irradiation: A narrative reviewAlexis N. ReindersEilidh M. O’BrienGregory Mark HermannBreast-conserving surgery with whole breast irradiation (WBI) is the standard of care for early-stage breast cancer which provides similar local control and survival outcomes to mastectomy alone. Advances in radiation therapy (RT), such as hypofractionated RT and accelerated partial breast irradiation (APBI), have demonstrated equivalent cancer control with the benefit of lower cardiac exposure. We conducted a comprehensive literature search from May 2024 to July 2024, focusing on search terms related to breast irradiation and cardiac toxicity. We reviewed and included 34 articles on cardiac dosing (i.e., mean heart dose and left anterior descending (LAD) coronary artery dose). The purpose of our study was to review the current literature on cardiac dosing in breast cancer patients with a focus on comparing the cardiac toxicity of WBI versus APBI. APBI is noninferior to WBI with regard to local recurrence, although APBI techniques differ in their efficacy. Notably, most APBI techniques display superiority with regard to reducing cardiac toxicity. Additional studies are needed to compare cardiac toxicity between APBI techniques and the long-term effects of APBI versus WBI. In conclusion, compared to WBI, APBI provides notable benefits, such as reduced heart radiation exposure and long-term coronary event risks while offering a more convenient and accessible treatment schedule.https://journals.lww.com/10.4103/aort.aort_45_24accelerated partial breast radiotherapybreast cancerbreast irradiationbreast-conserving surgerypartial breast irradiationradiation oncology |
| spellingShingle | Alexis N. Reinders Eilidh M. O’Brien Gregory Mark Hermann Comparing cardiac radiation dose between accelerated partial breast irradiation and whole breast irradiation: A narrative review Annals of Oncology Research and Therapy accelerated partial breast radiotherapy breast cancer breast irradiation breast-conserving surgery partial breast irradiation radiation oncology |
| title | Comparing cardiac radiation dose between accelerated partial breast irradiation and whole breast irradiation: A narrative review |
| title_full | Comparing cardiac radiation dose between accelerated partial breast irradiation and whole breast irradiation: A narrative review |
| title_fullStr | Comparing cardiac radiation dose between accelerated partial breast irradiation and whole breast irradiation: A narrative review |
| title_full_unstemmed | Comparing cardiac radiation dose between accelerated partial breast irradiation and whole breast irradiation: A narrative review |
| title_short | Comparing cardiac radiation dose between accelerated partial breast irradiation and whole breast irradiation: A narrative review |
| title_sort | comparing cardiac radiation dose between accelerated partial breast irradiation and whole breast irradiation a narrative review |
| topic | accelerated partial breast radiotherapy breast cancer breast irradiation breast-conserving surgery partial breast irradiation radiation oncology |
| url | https://journals.lww.com/10.4103/aort.aort_45_24 |
| work_keys_str_mv | AT alexisnreinders comparingcardiacradiationdosebetweenacceleratedpartialbreastirradiationandwholebreastirradiationanarrativereview AT eilidhmobrien comparingcardiacradiationdosebetweenacceleratedpartialbreastirradiationandwholebreastirradiationanarrativereview AT gregorymarkhermann comparingcardiacradiationdosebetweenacceleratedpartialbreastirradiationandwholebreastirradiationanarrativereview |