HBOC alleviated tumour hypoxia during radiotherapy more intensely in large solid tumours than regular ones

HBOC alleviated tumour hypoxia during radiotherapy more intensely in large solid tumours than regular ones

Radiotherapy (RT) is a highly valuable method in cancer therapy, but its therapeutic efficacy is limited by its side effects and tumour radiation resistance. The resistance is mainly induced by hypoxia in the tumour microenvironment (TME). As a nano-oxygen carrier, Haemoglobin-based oxygen carriers...

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Bibliographic Details
Main Authors: Yingcan Xu, Kehui Zhu, Jiakang Wu, Shifan Zheng, Rui Zhong, Wentao Zhou, Ye Cao, Jiaxin Liu, Hong Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Artificial Cells, Nanomedicine, and Biotechnology
Subjects:
Haemoglobin-based oxygen carriers (HBOCs)
tumor hypoxia
radiotherapy
xenograft
Hif-1α
Online Access:https://www.tandfonline.com/doi/10.1080/21691401.2023.2276768
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