Dopamine-Sensitive Anterior Cingulate Cortical Glucose-Monitoring Neurons as Potential Therapeutic Targets for Gustatory and Other Behavior Alterations
<b>Background</b>: The anterior cingulate cortex (ACC) is known for its involvement in various regulatory functions, including in the central control of feeding. Activation of local elements of the central glucose-monitoring (GM) neuronal network appears to be indispensable in these regu...
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2024-12-01
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| author | Edina Hormay Bettina László István Szabó Kitti Mintál Beáta Berta Tamás Ollmann László Péczely Bernadett Nagy Attila Tóth Kristóf László László Lénárd Zoltán Karádi |
| author_facet | Edina Hormay Bettina László István Szabó Kitti Mintál Beáta Berta Tamás Ollmann László Péczely Bernadett Nagy Attila Tóth Kristóf László László Lénárd Zoltán Karádi |
| author_sort | Edina Hormay |
| collection | DOAJ |
| description | <b>Background</b>: The anterior cingulate cortex (ACC) is known for its involvement in various regulatory functions, including in the central control of feeding. Activation of local elements of the central glucose-monitoring (GM) neuronal network appears to be indispensable in these regulatory processes. Destruction of these type 2 glucose transporter protein (GLUT2)-equipped chemosensory cells results in multiple feeding-associated functional alterations. <b>Methods</b>: In order to examine this complex symptomatology, (1) dopamine sensitivity was studied in laboratory rats by means of the single-neuron-recording multibarreled microelectrophoretic technique, and (2) after local bilateral microinjection of the selective type 2 glucose transporter proteindemolishing streptozotocin (STZ), open-field, elevated plus maze, two-bottle and taste reactivity tests were performed. <b>Results</b>: A high proportion of the anterior cingulate cortical neurons changed their firing rate in response to microelectrophoretic administration of D-glucose, thus verifying them as local elements of the central glucose-monitoring network. Approximately 20% of the recorded cells displayed activity changes in response to microelectrophoretic application of dopamine, and almost 50% of the glucose-monitoring units here proved to be dopamine-sensitive. Moreover, taste stimulation experiments revealed even higher (80%) gustatory sensitivity dominance of these chemosensory cells. The anterior cingulate cortical STZ microinjections resulted in extensive behavioral and taste-associated functional deficits. <b>Conclusions</b>: The present findings provided evidence for the selective loss of glucose-monitoring neurons in the anterior cingulate cortex leading to motivated behavioral and gustatory alterations. This complex dataset also underlines the varied significance of the type 2 glucose transporter protein-equipped, dopamine-sensitive glucose-monitoring neurons as potential therapeutic targets. These units appear to be indispensable in adaptive control mechanisms of the homeostatic–motivational–emotional–cognitive balance for the overall well-being of the organism. |
| format | Article |
| id | doaj-art-ff84cba0e6a5437e887f9726c856dd04 |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-12-01 |
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| series | Biomedicines |
| spelling | doaj-art-ff84cba0e6a5437e887f9726c856dd042025-08-20T02:57:12ZengMDPI AGBiomedicines2227-90592024-12-011212280310.3390/biomedicines12122803Dopamine-Sensitive Anterior Cingulate Cortical Glucose-Monitoring Neurons as Potential Therapeutic Targets for Gustatory and Other Behavior AlterationsEdina Hormay0Bettina László1István Szabó2Kitti Mintál3Beáta Berta4Tamás Ollmann5László Péczely6Bernadett Nagy7Attila Tóth8Kristóf László9László Lénárd10Zoltán Karádi11Institute of Physiology, Medical School, University of Pécs, H-7624 Pécs, HungaryInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, HungaryInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, HungaryInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, HungaryInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, HungaryInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, HungaryInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, HungaryInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, HungaryInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, HungaryInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, HungaryInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, HungaryInstitute of Physiology, Medical School, University of Pécs, H-7624 Pécs, Hungary<b>Background</b>: The anterior cingulate cortex (ACC) is known for its involvement in various regulatory functions, including in the central control of feeding. Activation of local elements of the central glucose-monitoring (GM) neuronal network appears to be indispensable in these regulatory processes. Destruction of these type 2 glucose transporter protein (GLUT2)-equipped chemosensory cells results in multiple feeding-associated functional alterations. <b>Methods</b>: In order to examine this complex symptomatology, (1) dopamine sensitivity was studied in laboratory rats by means of the single-neuron-recording multibarreled microelectrophoretic technique, and (2) after local bilateral microinjection of the selective type 2 glucose transporter proteindemolishing streptozotocin (STZ), open-field, elevated plus maze, two-bottle and taste reactivity tests were performed. <b>Results</b>: A high proportion of the anterior cingulate cortical neurons changed their firing rate in response to microelectrophoretic administration of D-glucose, thus verifying them as local elements of the central glucose-monitoring network. Approximately 20% of the recorded cells displayed activity changes in response to microelectrophoretic application of dopamine, and almost 50% of the glucose-monitoring units here proved to be dopamine-sensitive. Moreover, taste stimulation experiments revealed even higher (80%) gustatory sensitivity dominance of these chemosensory cells. The anterior cingulate cortical STZ microinjections resulted in extensive behavioral and taste-associated functional deficits. <b>Conclusions</b>: The present findings provided evidence for the selective loss of glucose-monitoring neurons in the anterior cingulate cortex leading to motivated behavioral and gustatory alterations. This complex dataset also underlines the varied significance of the type 2 glucose transporter protein-equipped, dopamine-sensitive glucose-monitoring neurons as potential therapeutic targets. These units appear to be indispensable in adaptive control mechanisms of the homeostatic–motivational–emotional–cognitive balance for the overall well-being of the organism.https://www.mdpi.com/2227-9059/12/12/2803anterior cingulate cortexglucose-monitoring neurondopaminestreptozotocinbehavior |
| spellingShingle | Edina Hormay Bettina László István Szabó Kitti Mintál Beáta Berta Tamás Ollmann László Péczely Bernadett Nagy Attila Tóth Kristóf László László Lénárd Zoltán Karádi Dopamine-Sensitive Anterior Cingulate Cortical Glucose-Monitoring Neurons as Potential Therapeutic Targets for Gustatory and Other Behavior Alterations Biomedicines anterior cingulate cortex glucose-monitoring neuron dopamine streptozotocin behavior |
| title | Dopamine-Sensitive Anterior Cingulate Cortical Glucose-Monitoring Neurons as Potential Therapeutic Targets for Gustatory and Other Behavior Alterations |
| title_full | Dopamine-Sensitive Anterior Cingulate Cortical Glucose-Monitoring Neurons as Potential Therapeutic Targets for Gustatory and Other Behavior Alterations |
| title_fullStr | Dopamine-Sensitive Anterior Cingulate Cortical Glucose-Monitoring Neurons as Potential Therapeutic Targets for Gustatory and Other Behavior Alterations |
| title_full_unstemmed | Dopamine-Sensitive Anterior Cingulate Cortical Glucose-Monitoring Neurons as Potential Therapeutic Targets for Gustatory and Other Behavior Alterations |
| title_short | Dopamine-Sensitive Anterior Cingulate Cortical Glucose-Monitoring Neurons as Potential Therapeutic Targets for Gustatory and Other Behavior Alterations |
| title_sort | dopamine sensitive anterior cingulate cortical glucose monitoring neurons as potential therapeutic targets for gustatory and other behavior alterations |
| topic | anterior cingulate cortex glucose-monitoring neuron dopamine streptozotocin behavior |
| url | https://www.mdpi.com/2227-9059/12/12/2803 |
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