Ferroptosis, oxidative stress and hearing loss: Mechanistic insights and therapeutic opportunities
Hearing loss, a prevalent sensory impairment, poses significant challenges worldwide. Recent research has shed light on the intricate interplay between ferroptosis, a newly recognized form of regulated cell death characterized by iron-dependent lipid peroxidation, and oxidative stress in the pathoge...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-10-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024145847 |
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| author | Chenyang Yuan Tianyu Ma Mengting Liu Xiaoyun Zeng Gongrui Tang Yazhi Xing Tianhong Zhang |
| author_facet | Chenyang Yuan Tianyu Ma Mengting Liu Xiaoyun Zeng Gongrui Tang Yazhi Xing Tianhong Zhang |
| author_sort | Chenyang Yuan |
| collection | DOAJ |
| description | Hearing loss, a prevalent sensory impairment, poses significant challenges worldwide. Recent research has shed light on the intricate interplay between ferroptosis, a newly recognized form of regulated cell death characterized by iron-dependent lipid peroxidation, and oxidative stress in the pathogenesis of hearing loss. In this review, we delve into the mechanisms underlying ferroptosis and oxidative stress in various forms of hearing loss, including age-related hearing loss (ARHL), noise-induced hearing loss (NIHL) ototoxic drug-induced hearing loss and genetic hearing loss. We discuss the pivotal role of molecules such as FSP1, ACSL4, LKB1-AMPK, and Nrf2 in modulating these pathways in hearing loss. Furthermore, we explore emerging therapeutic strategies targeting the antioxidant system and ferroptosis, including iron chelators, lipid peroxide inhibitors, and antioxidants, highlighting their potential in mitigating hearing loss progression. By elucidating the molecular mechanisms underlying ferroptosis and oxidative stress, this review offers insights into novel therapeutic avenues for the treatment of hearing loss and underscores the importance of targeting these pathways to preserve auditory function. |
| format | Article |
| id | doaj-art-ff83174010bf42e29e990fe2b19b643f |
| institution | OA Journals |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-ff83174010bf42e29e990fe2b19b643f2025-08-20T02:14:03ZengElsevierHeliyon2405-84402024-10-011020e3855310.1016/j.heliyon.2024.e38553Ferroptosis, oxidative stress and hearing loss: Mechanistic insights and therapeutic opportunitiesChenyang Yuan0Tianyu Ma1Mengting Liu2Xiaoyun Zeng3Gongrui Tang4Yazhi Xing5Tianhong Zhang6Department of Otorhinolaryngology Head and Neck surgery, The First Hospital affiliated to Harbin Medical University, Harbin, Heilongjiang, ChinaDepartment of Otorhinolaryngology Head and Neck surgery, The First Hospital affiliated to Harbin Medical University, Harbin, Heilongjiang, ChinaDepartment of Otorhinolaryngology Head and Neck surgery, The First Hospital affiliated to Harbin Medical University, Harbin, Heilongjiang, ChinaDepartment of Otorhinolaryngology Head and Neck surgery, The First Hospital affiliated to Harbin Medical University, Harbin, Heilongjiang, ChinaDepartment of Otorhinolaryngology Head and Neck surgery, The First Hospital affiliated to Harbin Medical University, Harbin, Heilongjiang, ChinaDepartment of Otolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Key Laboratory of Sleep Disordered Breathing, 600 Yishan Rd, Shanghai, 200233, China; Corresponding author.Department of Otorhinolaryngology Head and Neck surgery, The First Hospital affiliated to Harbin Medical University, Harbin, Heilongjiang, China; Corresponding author.Hearing loss, a prevalent sensory impairment, poses significant challenges worldwide. Recent research has shed light on the intricate interplay between ferroptosis, a newly recognized form of regulated cell death characterized by iron-dependent lipid peroxidation, and oxidative stress in the pathogenesis of hearing loss. In this review, we delve into the mechanisms underlying ferroptosis and oxidative stress in various forms of hearing loss, including age-related hearing loss (ARHL), noise-induced hearing loss (NIHL) ototoxic drug-induced hearing loss and genetic hearing loss. We discuss the pivotal role of molecules such as FSP1, ACSL4, LKB1-AMPK, and Nrf2 in modulating these pathways in hearing loss. Furthermore, we explore emerging therapeutic strategies targeting the antioxidant system and ferroptosis, including iron chelators, lipid peroxide inhibitors, and antioxidants, highlighting their potential in mitigating hearing loss progression. By elucidating the molecular mechanisms underlying ferroptosis and oxidative stress, this review offers insights into novel therapeutic avenues for the treatment of hearing loss and underscores the importance of targeting these pathways to preserve auditory function.http://www.sciencedirect.com/science/article/pii/S2405844024145847FerroptosisOxidative stressHearing lossHair cells |
| spellingShingle | Chenyang Yuan Tianyu Ma Mengting Liu Xiaoyun Zeng Gongrui Tang Yazhi Xing Tianhong Zhang Ferroptosis, oxidative stress and hearing loss: Mechanistic insights and therapeutic opportunities Heliyon Ferroptosis Oxidative stress Hearing loss Hair cells |
| title | Ferroptosis, oxidative stress and hearing loss: Mechanistic insights and therapeutic opportunities |
| title_full | Ferroptosis, oxidative stress and hearing loss: Mechanistic insights and therapeutic opportunities |
| title_fullStr | Ferroptosis, oxidative stress and hearing loss: Mechanistic insights and therapeutic opportunities |
| title_full_unstemmed | Ferroptosis, oxidative stress and hearing loss: Mechanistic insights and therapeutic opportunities |
| title_short | Ferroptosis, oxidative stress and hearing loss: Mechanistic insights and therapeutic opportunities |
| title_sort | ferroptosis oxidative stress and hearing loss mechanistic insights and therapeutic opportunities |
| topic | Ferroptosis Oxidative stress Hearing loss Hair cells |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024145847 |
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