Comparative Analysis of Metabolites of Wild and Cultivated <i>Notopterygium incisum</i> from Different Origins and Evaluation of Their Anti-Inflammatory Activity
The dried rhizome of <i>Notopterygium incisum</i> (NI) from the <i>Umbelliferae</i> family, genuinely produced in Sichuan, China, is a classic traditional Chinese medicinal herb for treating wind-dampness arthralgia. Due to scarce natural resources, wild NI is gradually being...
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2025-01-01
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| author | Fukang Kong Yannan Kou Xu Zhang Yue Tian Bin Yang Weihao Wang |
| author_facet | Fukang Kong Yannan Kou Xu Zhang Yue Tian Bin Yang Weihao Wang |
| author_sort | Fukang Kong |
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| description | The dried rhizome of <i>Notopterygium incisum</i> (NI) from the <i>Umbelliferae</i> family, genuinely produced in Sichuan, China, is a classic traditional Chinese medicinal herb for treating wind-dampness arthralgia. Due to scarce natural resources, wild NI is gradually being replaced by cultivated types. However, knowledge is limited regarding the differences in chemical composition and pharmacological effects between wild and cultivated NI and between Sichuan-grown and other-region-grown NI. In this study, a plant metabolomics strategy, based on GC–MS and UHPLC-Orbitrap MS, was employed to compare metabolic profiles between wild and cultivated NI and between cultivated NI from Sichuan and cultivated NI from Gansu and Qinghai. In total, 195 metabolites were identified, and the biosynthetic pathways of coumarins and phenolic acids, which were the most abundant secondary metabolites in NI, were summarized. Additionally, seven key metabolic intermediates were uncovered, revealing the reasons for the differences in metabolic profiles between wild and cultivated NI. The anti-inflammatory effect of wild and cultivated NI was verified by inflammatory gene expression and neutrophil count using a zebrafish yolk sac inflammation model. Overall, this study presents information on the types and synthesis of pharmacodynamic substances in NI and provides a basis for its cultivation and applications. |
| format | Article |
| id | doaj-art-ff7a6a42d96647b3862d754e2dbb2618 |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Molecules |
| spelling | doaj-art-ff7a6a42d96647b3862d754e2dbb26182025-08-20T02:12:28ZengMDPI AGMolecules1420-30492025-01-0130346810.3390/molecules30030468Comparative Analysis of Metabolites of Wild and Cultivated <i>Notopterygium incisum</i> from Different Origins and Evaluation of Their Anti-Inflammatory ActivityFukang Kong0Yannan Kou1Xu Zhang2Yue Tian3Bin Yang4Weihao Wang5State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaSchool of Biomedicine, Beijing City University, No. 6 Huanghoudian Road, Haidian District, Beijing 100094, ChinaState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaState Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaThe dried rhizome of <i>Notopterygium incisum</i> (NI) from the <i>Umbelliferae</i> family, genuinely produced in Sichuan, China, is a classic traditional Chinese medicinal herb for treating wind-dampness arthralgia. Due to scarce natural resources, wild NI is gradually being replaced by cultivated types. However, knowledge is limited regarding the differences in chemical composition and pharmacological effects between wild and cultivated NI and between Sichuan-grown and other-region-grown NI. In this study, a plant metabolomics strategy, based on GC–MS and UHPLC-Orbitrap MS, was employed to compare metabolic profiles between wild and cultivated NI and between cultivated NI from Sichuan and cultivated NI from Gansu and Qinghai. In total, 195 metabolites were identified, and the biosynthetic pathways of coumarins and phenolic acids, which were the most abundant secondary metabolites in NI, were summarized. Additionally, seven key metabolic intermediates were uncovered, revealing the reasons for the differences in metabolic profiles between wild and cultivated NI. The anti-inflammatory effect of wild and cultivated NI was verified by inflammatory gene expression and neutrophil count using a zebrafish yolk sac inflammation model. Overall, this study presents information on the types and synthesis of pharmacodynamic substances in NI and provides a basis for its cultivation and applications.https://www.mdpi.com/1420-3049/30/3/468<i>Notopterygium incisum</i>phytometabolomicUHPLC-Orbitrap MSGC–MScoumarinphenolic acid |
| spellingShingle | Fukang Kong Yannan Kou Xu Zhang Yue Tian Bin Yang Weihao Wang Comparative Analysis of Metabolites of Wild and Cultivated <i>Notopterygium incisum</i> from Different Origins and Evaluation of Their Anti-Inflammatory Activity Molecules <i>Notopterygium incisum</i> phytometabolomic UHPLC-Orbitrap MS GC–MS coumarin phenolic acid |
| title | Comparative Analysis of Metabolites of Wild and Cultivated <i>Notopterygium incisum</i> from Different Origins and Evaluation of Their Anti-Inflammatory Activity |
| title_full | Comparative Analysis of Metabolites of Wild and Cultivated <i>Notopterygium incisum</i> from Different Origins and Evaluation of Their Anti-Inflammatory Activity |
| title_fullStr | Comparative Analysis of Metabolites of Wild and Cultivated <i>Notopterygium incisum</i> from Different Origins and Evaluation of Their Anti-Inflammatory Activity |
| title_full_unstemmed | Comparative Analysis of Metabolites of Wild and Cultivated <i>Notopterygium incisum</i> from Different Origins and Evaluation of Their Anti-Inflammatory Activity |
| title_short | Comparative Analysis of Metabolites of Wild and Cultivated <i>Notopterygium incisum</i> from Different Origins and Evaluation of Their Anti-Inflammatory Activity |
| title_sort | comparative analysis of metabolites of wild and cultivated i notopterygium incisum i from different origins and evaluation of their anti inflammatory activity |
| topic | <i>Notopterygium incisum</i> phytometabolomic UHPLC-Orbitrap MS GC–MS coumarin phenolic acid |
| url | https://www.mdpi.com/1420-3049/30/3/468 |
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