Isolated Single Umbilical Artery and Histomorphometric Changes of Umbilical Blood Vessels in Intrauterine Growth Retarded Foetus in Comparison to Normal Neonates
Background: Three vessels—one vein and two arteries—allow the fetus and placenta to exchange waste, oxygen, and nutrients in the umbilical cord. Single umbilical artery (SUA), a congenital abnormality with one umbilical artery, can occur in some pregnancies. Materials and Methods: The current observ...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_543_25 |
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| author | Dinesh Kumar Jagdish S. Soni |
| author_facet | Dinesh Kumar Jagdish S. Soni |
| author_sort | Dinesh Kumar |
| collection | DOAJ |
| description | Background:
Three vessels—one vein and two arteries—allow the fetus and placenta to exchange waste, oxygen, and nutrients in the umbilical cord. Single umbilical artery (SUA), a congenital abnormality with one umbilical artery, can occur in some pregnancies.
Materials and Methods:
The current observational study was conducted at the Parul Institute of Medical Sciences and Research, Waghodia, Vadodara, Gujarat. Ten percent formalin was used to preserve 5 cm segment of the placental cord after delivery. Paraffin-embedded slices were produced, and H and E staining was performed on a 3 μm segment.
Results:
This study compared 125 normal and 125 intrauterine growth restriction (IUGR) infant umbilical cords. IUGR neonates had significantly thinner umbilical vessel walls than normal newborns, although their cross-sectional area was similar between sexes.
Conclusion:
The thickness of umbilical cord blood arteries affects IUGR, according to this study. These large vessel wall thickness changes may indicate IUGR or associated disorders. |
| format | Article |
| id | doaj-art-ff7a5cd8ac55494e9eda3afcb155018e |
| institution | OA Journals |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-ff7a5cd8ac55494e9eda3afcb155018e2025-08-20T02:03:24ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062025-05-0117Suppl 1S770S77310.4103/jpbs.jpbs_543_25Isolated Single Umbilical Artery and Histomorphometric Changes of Umbilical Blood Vessels in Intrauterine Growth Retarded Foetus in Comparison to Normal NeonatesDinesh KumarJagdish S. SoniBackground: Three vessels—one vein and two arteries—allow the fetus and placenta to exchange waste, oxygen, and nutrients in the umbilical cord. Single umbilical artery (SUA), a congenital abnormality with one umbilical artery, can occur in some pregnancies. Materials and Methods: The current observational study was conducted at the Parul Institute of Medical Sciences and Research, Waghodia, Vadodara, Gujarat. Ten percent formalin was used to preserve 5 cm segment of the placental cord after delivery. Paraffin-embedded slices were produced, and H and E staining was performed on a 3 μm segment. Results: This study compared 125 normal and 125 intrauterine growth restriction (IUGR) infant umbilical cords. IUGR neonates had significantly thinner umbilical vessel walls than normal newborns, although their cross-sectional area was similar between sexes. Conclusion: The thickness of umbilical cord blood arteries affects IUGR, according to this study. These large vessel wall thickness changes may indicate IUGR or associated disorders.https://journals.lww.com/10.4103/jpbs.jpbs_543_25fetushistopathologyplacentaumbilical cord blood vessels |
| spellingShingle | Dinesh Kumar Jagdish S. Soni Isolated Single Umbilical Artery and Histomorphometric Changes of Umbilical Blood Vessels in Intrauterine Growth Retarded Foetus in Comparison to Normal Neonates Journal of Pharmacy and Bioallied Sciences fetus histopathology placenta umbilical cord blood vessels |
| title | Isolated Single Umbilical Artery and Histomorphometric Changes of Umbilical Blood Vessels in Intrauterine Growth Retarded Foetus in Comparison to Normal Neonates |
| title_full | Isolated Single Umbilical Artery and Histomorphometric Changes of Umbilical Blood Vessels in Intrauterine Growth Retarded Foetus in Comparison to Normal Neonates |
| title_fullStr | Isolated Single Umbilical Artery and Histomorphometric Changes of Umbilical Blood Vessels in Intrauterine Growth Retarded Foetus in Comparison to Normal Neonates |
| title_full_unstemmed | Isolated Single Umbilical Artery and Histomorphometric Changes of Umbilical Blood Vessels in Intrauterine Growth Retarded Foetus in Comparison to Normal Neonates |
| title_short | Isolated Single Umbilical Artery and Histomorphometric Changes of Umbilical Blood Vessels in Intrauterine Growth Retarded Foetus in Comparison to Normal Neonates |
| title_sort | isolated single umbilical artery and histomorphometric changes of umbilical blood vessels in intrauterine growth retarded foetus in comparison to normal neonates |
| topic | fetus histopathology placenta umbilical cord blood vessels |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_543_25 |
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