Isolated Single Umbilical Artery and Histomorphometric Changes of Umbilical Blood Vessels in Intrauterine Growth Retarded Foetus in Comparison to Normal Neonates
Background: Three vessels—one vein and two arteries—allow the fetus and placenta to exchange waste, oxygen, and nutrients in the umbilical cord. Single umbilical artery (SUA), a congenital abnormality with one umbilical artery, can occur in some pregnancies. Materials and Methods: The current observ...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_543_25 |
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| Summary: | Background:
Three vessels—one vein and two arteries—allow the fetus and placenta to exchange waste, oxygen, and nutrients in the umbilical cord. Single umbilical artery (SUA), a congenital abnormality with one umbilical artery, can occur in some pregnancies.
Materials and Methods:
The current observational study was conducted at the Parul Institute of Medical Sciences and Research, Waghodia, Vadodara, Gujarat. Ten percent formalin was used to preserve 5 cm segment of the placental cord after delivery. Paraffin-embedded slices were produced, and H and E staining was performed on a 3 μm segment.
Results:
This study compared 125 normal and 125 intrauterine growth restriction (IUGR) infant umbilical cords. IUGR neonates had significantly thinner umbilical vessel walls than normal newborns, although their cross-sectional area was similar between sexes.
Conclusion:
The thickness of umbilical cord blood arteries affects IUGR, according to this study. These large vessel wall thickness changes may indicate IUGR or associated disorders. |
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| ISSN: | 0976-4879 0975-7406 |