TREATMENT OF STATUS EPILEPTICUS IN INFANCY AND EARLY CHILDHOOD
The problem of status epilepticus (SE) in infancy and early childhood is very important due to a high occurrence of SE, serious consequences of prolonged seizures for the child's developing brain, atypical variants of SE accompanying specific age-dependant forms of epilepsy in the first year of...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Union of pediatricians of Russia
2012-06-01
|
| Series: | Педиатрическая фармакология |
| Subjects: | |
| Online Access: | https://www.pedpharma.ru/jour/article/view/326 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850045983843418112 |
|---|---|
| author | А. А. Kholin E. S. Ilina N. N. Zavadenko |
| author_facet | А. А. Kholin E. S. Ilina N. N. Zavadenko |
| author_sort | А. А. Kholin |
| collection | DOAJ |
| description | The problem of status epilepticus (SE) in infancy and early childhood is very important due to a high occurrence of SE, serious consequences of prolonged seizures for the child's developing brain, atypical variants of SE accompanying specific age-dependant forms of epilepsy in the first year of life (infantile epileptic encephalopathies), high rate of pharmacoresistant forms and severe disability of patients. Out of the total of 407 pediatric patients with revealed cases of SE 267 children had the SE onset before 3 years of age (65,6%), and 147 patients (36,1%) had SE onset in infancy. In the structure of ES at infancy and early childhood 38,6% of cases were represented by epileptic encephalopathies, 27% — by focal forms of epilepsy, 15,7% — hereditary neurodegenerations, 14,2% — acute symptomatic SE and 4,5% — isolated febrile SE. SE in infancy was treated with benzodiasepines — diazepam (0,5 mg/kg per rectum, i. m. or i. v.), midazolam (0,15–0,4 mg/kg i. v. in bolus, supporting infusion — 1–3 µg/kg/min), and valproates (convulex) in the initial dose of 10–25 mg/kg followed by a supporting infusion of 1–4 mg/kg/hour. The refractory cases of SE were treated with sodium oxybate (100–150 mg/kg with the speed of 400 mg/min), propofol (3 mg/kg i. v. in bolus followed by a supporting infusion — 100 µg/kg/min), sodium thiopental (4 mg/kg followed after 2 minutes by an infusion of 0,2 mg/kg/min). |
| format | Article |
| id | doaj-art-ff79b3c9407a479f8d882cb585c153cc |
| institution | DOAJ |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2012-06-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-ff79b3c9407a479f8d882cb585c153cc2025-08-20T02:54:35ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892012-06-0193586410.15690/pf.v9i3.323326TREATMENT OF STATUS EPILEPTICUS IN INFANCY AND EARLY CHILDHOODА. А. Kholin0E. S. Ilina1N. N. Zavadenko2N.I. Pirogov Russian National Research Medical University, Ministry of Health and Social Development of Russian Federation, Moscow Russian Children’s Clinical Hospital, MoscowRussian Children’s Clinical Hospital, MoscowN.I. Pirogov Russian National Research Medical University, Ministry of Health and Social Development of Russian Federation, MoscowThe problem of status epilepticus (SE) in infancy and early childhood is very important due to a high occurrence of SE, serious consequences of prolonged seizures for the child's developing brain, atypical variants of SE accompanying specific age-dependant forms of epilepsy in the first year of life (infantile epileptic encephalopathies), high rate of pharmacoresistant forms and severe disability of patients. Out of the total of 407 pediatric patients with revealed cases of SE 267 children had the SE onset before 3 years of age (65,6%), and 147 patients (36,1%) had SE onset in infancy. In the structure of ES at infancy and early childhood 38,6% of cases were represented by epileptic encephalopathies, 27% — by focal forms of epilepsy, 15,7% — hereditary neurodegenerations, 14,2% — acute symptomatic SE and 4,5% — isolated febrile SE. SE in infancy was treated with benzodiasepines — diazepam (0,5 mg/kg per rectum, i. m. or i. v.), midazolam (0,15–0,4 mg/kg i. v. in bolus, supporting infusion — 1–3 µg/kg/min), and valproates (convulex) in the initial dose of 10–25 mg/kg followed by a supporting infusion of 1–4 mg/kg/hour. The refractory cases of SE were treated with sodium oxybate (100–150 mg/kg with the speed of 400 mg/min), propofol (3 mg/kg i. v. in bolus followed by a supporting infusion — 100 µg/kg/min), sodium thiopental (4 mg/kg followed after 2 minutes by an infusion of 0,2 mg/kg/min).https://www.pedpharma.ru/jour/article/view/326status epilepticusepileptic encephalopathiesinfancy malignant migrating partial seizures. |
| spellingShingle | А. А. Kholin E. S. Ilina N. N. Zavadenko TREATMENT OF STATUS EPILEPTICUS IN INFANCY AND EARLY CHILDHOOD Педиатрическая фармакология status epilepticus epileptic encephalopathies infancy malignant migrating partial seizures. |
| title | TREATMENT OF STATUS EPILEPTICUS IN INFANCY AND EARLY CHILDHOOD |
| title_full | TREATMENT OF STATUS EPILEPTICUS IN INFANCY AND EARLY CHILDHOOD |
| title_fullStr | TREATMENT OF STATUS EPILEPTICUS IN INFANCY AND EARLY CHILDHOOD |
| title_full_unstemmed | TREATMENT OF STATUS EPILEPTICUS IN INFANCY AND EARLY CHILDHOOD |
| title_short | TREATMENT OF STATUS EPILEPTICUS IN INFANCY AND EARLY CHILDHOOD |
| title_sort | treatment of status epilepticus in infancy and early childhood |
| topic | status epilepticus epileptic encephalopathies infancy malignant migrating partial seizures. |
| url | https://www.pedpharma.ru/jour/article/view/326 |
| work_keys_str_mv | AT aakholin treatmentofstatusepilepticusininfancyandearlychildhood AT esilina treatmentofstatusepilepticusininfancyandearlychildhood AT nnzavadenko treatmentofstatusepilepticusininfancyandearlychildhood |