Genetic aspects of non-alcoholic fatty liver disease development
Progression of non-alcoholic fatty liver disease (NAFLD) is conditioned by genetic susceptibility, environmental factors, lifestyle and features of the metabolic syndrome, many of which overlap with hepatocellular carcinoma. However, the multifactorial nature of NAFLD and the limited number of suffi...
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| Format: | Article |
| Language: | Russian |
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Open Systems Publication
2021-06-01
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| Series: | Лечащий Врач |
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| Online Access: | https://journal.lvrach.ru/jour/article/view/316 |
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| _version_ | 1849345206793535488 |
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| author | V. A. Akhmedov T. I. Melikov |
| author_facet | V. A. Akhmedov T. I. Melikov |
| author_sort | V. A. Akhmedov |
| collection | DOAJ |
| description | Progression of non-alcoholic fatty liver disease (NAFLD) is conditioned by genetic susceptibility, environmental factors, lifestyle and features of the metabolic syndrome, many of which overlap with hepatocellular carcinoma. However, the multifactorial nature of NAFLD and the limited number of sufficiently powerful studies are among the current limitations for validated biomarkers of clinical utility. Further studies incorporating the links between circadian regulation and hepatic metabolism may represent an additional direction in the search for predictive biomarkers of liver disease progression and treatment outcomes. |
| format | Article |
| id | doaj-art-ff7887c043284849aa920439bfe912b6 |
| institution | Kabale University |
| issn | 1560-5175 2687-1181 |
| language | Russian |
| publishDate | 2021-06-01 |
| publisher | Open Systems Publication |
| record_format | Article |
| series | Лечащий Врач |
| spelling | doaj-art-ff7887c043284849aa920439bfe912b62025-08-20T03:42:31ZrusOpen Systems PublicationЛечащий Врач1560-51752687-11812021-06-0108315Genetic aspects of non-alcoholic fatty liver disease developmentV. A. Akhmedov0T. I. Melikov1ФГБОУ ВО ОмГМУ МЗ РФФГБОУ ВО ОмГМУ МЗ РФProgression of non-alcoholic fatty liver disease (NAFLD) is conditioned by genetic susceptibility, environmental factors, lifestyle and features of the metabolic syndrome, many of which overlap with hepatocellular carcinoma. However, the multifactorial nature of NAFLD and the limited number of sufficiently powerful studies are among the current limitations for validated biomarkers of clinical utility. Further studies incorporating the links between circadian regulation and hepatic metabolism may represent an additional direction in the search for predictive biomarkers of liver disease progression and treatment outcomes.https://journal.lvrach.ru/jour/article/view/316non-alcoholic fatty liver diseasenon-alcoholic steatohepatitishepatocellular carcinomametabolic syndromegenomegwas |
| spellingShingle | V. A. Akhmedov T. I. Melikov Genetic aspects of non-alcoholic fatty liver disease development Лечащий Врач non-alcoholic fatty liver disease non-alcoholic steatohepatitis hepatocellular carcinoma metabolic syndrome genome gwas |
| title | Genetic aspects of non-alcoholic fatty liver disease development |
| title_full | Genetic aspects of non-alcoholic fatty liver disease development |
| title_fullStr | Genetic aspects of non-alcoholic fatty liver disease development |
| title_full_unstemmed | Genetic aspects of non-alcoholic fatty liver disease development |
| title_short | Genetic aspects of non-alcoholic fatty liver disease development |
| title_sort | genetic aspects of non alcoholic fatty liver disease development |
| topic | non-alcoholic fatty liver disease non-alcoholic steatohepatitis hepatocellular carcinoma metabolic syndrome genome gwas |
| url | https://journal.lvrach.ru/jour/article/view/316 |
| work_keys_str_mv | AT vaakhmedov geneticaspectsofnonalcoholicfattyliverdiseasedevelopment AT timelikov geneticaspectsofnonalcoholicfattyliverdiseasedevelopment |