The rising burden of Alzheimer’s and other dementias: role of high fasting plasma glucose from 1990 to 2021
BackgroundDementia, one of the top 10 causes of death globally, imposes significant health and socioeconomic/socioeconomic burdens, with prevalence projected to reach 82 million by 2030. High fasting plasma glucose (HFPG) is a prominent modifiable risk factor for dementia in 2021. This study aims fi...
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Frontiers Media S.A.
2025-06-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1592620/full |
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| author | Shuhua Liu Shuhua Liu Yuxuan Wu Fangying Chen Luying Han Yu Zhang Enqiang Chang Enqiang Chang Enqiang Chang Enqiang Chang |
| author_facet | Shuhua Liu Shuhua Liu Yuxuan Wu Fangying Chen Luying Han Yu Zhang Enqiang Chang Enqiang Chang Enqiang Chang Enqiang Chang |
| author_sort | Shuhua Liu |
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| description | BackgroundDementia, one of the top 10 causes of death globally, imposes significant health and socioeconomic/socioeconomic burdens, with prevalence projected to reach 82 million by 2030. High fasting plasma glucose (HFPG) is a prominent modifiable risk factor for dementia in 2021. This study aims first to examine the global trend in dementia burden and the disability-adjusted life years and death attributable to HFPG from 1990 to 2021 and second to define age-specific disparities in dementia burden among older populations.MethodsUsing data from the Global Burden of Diseases Study (GBD) 2021, this research evaluated the incidence, prevalence, deaths, disability-adjusted life years (DALYs), and HFPG-attributable burden related to Alzheimer’s disease and other dementias (ADOD). The estimated annual percentage change was calculated to qualify the burden change of ADOD.ResultsThere was a significant rise in the ADOD burden globally, with over 56.9 million prevalent cases and 2.0 million deaths in 2021. the incidence and prevalence were positively correlated with HFPG-related summary exposure value. The HFPG-attributable ADOD burden has increased worldwide over time. Globally, the 60 to 74 age groups suffered a prominent rise in the burden and HFPG-attributable burden of ADOD.ConclusionThe global burden and HFPG-attributable ADOD burden have remained prominent and have increased increase over the past 32 years. The ASIR and ASPR showed positive correlations with the SEV related to HFPG. Notably, the 60 to 74 age groups suffered a prominent rise in burden and HFPG attributable to the DALYs rate of ADOD over time. Moreover, a prominent positive correlation was observed between the incidence and prevalence rate with the SEVs related to HFPG occurred in the population aged 60 to 74 years old. Therefore, HFPG should be emphasized in strategic priorities for controlling the ADOD burden. |
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| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-06-01 |
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| series | Frontiers in Medicine |
| spelling | doaj-art-ff72b4e1eb15477eb877823c60e042f42025-08-20T03:29:58ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-06-011210.3389/fmed.2025.15926201592620The rising burden of Alzheimer’s and other dementias: role of high fasting plasma glucose from 1990 to 2021Shuhua Liu0Shuhua Liu1Yuxuan Wu2Fangying Chen3Luying Han4Yu Zhang5Enqiang Chang6Enqiang Chang7Enqiang Chang8Enqiang Chang9Department of Anesthesiology, Guangxi Medical University Cancer Hospital, Guangxi Clinical Research Center for Anesthesiology, Guangxi, ChinaDepartment of Anesthesiology and Perioperative Medicine, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Anesthesiology and Perioperative Medicine, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Anesthesiology and Perioperative Medicine, People's Hospital of Henan University, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Anesthesiology and Perioperative Medicine, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Anesthesiology and Perioperative Medicine, People's Hospital of Henan University, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Anesthesiology, Guangxi Medical University Cancer Hospital, Guangxi Clinical Research Center for Anesthesiology, Guangxi, ChinaDepartment of Anesthesiology and Perioperative Medicine, People’s Hospital of Zhengzhou University, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Anesthesiology and Perioperative Medicine, People's Hospital of Henan University, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDivision of Anesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital, London, United KingdomBackgroundDementia, one of the top 10 causes of death globally, imposes significant health and socioeconomic/socioeconomic burdens, with prevalence projected to reach 82 million by 2030. High fasting plasma glucose (HFPG) is a prominent modifiable risk factor for dementia in 2021. This study aims first to examine the global trend in dementia burden and the disability-adjusted life years and death attributable to HFPG from 1990 to 2021 and second to define age-specific disparities in dementia burden among older populations.MethodsUsing data from the Global Burden of Diseases Study (GBD) 2021, this research evaluated the incidence, prevalence, deaths, disability-adjusted life years (DALYs), and HFPG-attributable burden related to Alzheimer’s disease and other dementias (ADOD). The estimated annual percentage change was calculated to qualify the burden change of ADOD.ResultsThere was a significant rise in the ADOD burden globally, with over 56.9 million prevalent cases and 2.0 million deaths in 2021. the incidence and prevalence were positively correlated with HFPG-related summary exposure value. The HFPG-attributable ADOD burden has increased worldwide over time. Globally, the 60 to 74 age groups suffered a prominent rise in the burden and HFPG-attributable burden of ADOD.ConclusionThe global burden and HFPG-attributable ADOD burden have remained prominent and have increased increase over the past 32 years. The ASIR and ASPR showed positive correlations with the SEV related to HFPG. Notably, the 60 to 74 age groups suffered a prominent rise in burden and HFPG attributable to the DALYs rate of ADOD over time. Moreover, a prominent positive correlation was observed between the incidence and prevalence rate with the SEVs related to HFPG occurred in the population aged 60 to 74 years old. Therefore, HFPG should be emphasized in strategic priorities for controlling the ADOD burden.https://www.frontiersin.org/articles/10.3389/fmed.2025.1592620/fullAlzheimer’s disease and other dementiasprevalenceincidencedisability-adjusted life yearshigh fasting plasma glucose60 to 74 age groups |
| spellingShingle | Shuhua Liu Shuhua Liu Yuxuan Wu Fangying Chen Luying Han Yu Zhang Enqiang Chang Enqiang Chang Enqiang Chang Enqiang Chang The rising burden of Alzheimer’s and other dementias: role of high fasting plasma glucose from 1990 to 2021 Frontiers in Medicine Alzheimer’s disease and other dementias prevalence incidence disability-adjusted life years high fasting plasma glucose 60 to 74 age groups |
| title | The rising burden of Alzheimer’s and other dementias: role of high fasting plasma glucose from 1990 to 2021 |
| title_full | The rising burden of Alzheimer’s and other dementias: role of high fasting plasma glucose from 1990 to 2021 |
| title_fullStr | The rising burden of Alzheimer’s and other dementias: role of high fasting plasma glucose from 1990 to 2021 |
| title_full_unstemmed | The rising burden of Alzheimer’s and other dementias: role of high fasting plasma glucose from 1990 to 2021 |
| title_short | The rising burden of Alzheimer’s and other dementias: role of high fasting plasma glucose from 1990 to 2021 |
| title_sort | rising burden of alzheimer s and other dementias role of high fasting plasma glucose from 1990 to 2021 |
| topic | Alzheimer’s disease and other dementias prevalence incidence disability-adjusted life years high fasting plasma glucose 60 to 74 age groups |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1592620/full |
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