Hybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recording
Optogenetics enables precise neural control but is limited by conventional optical fibers in complex networks. We present a hybrid device integrating multi-point micro-light-emitting diodes (MicroLEDs) with neural electrodes for localized light stimulation and simultaneous neural recording. Fabricat...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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IOP Publishing
2025-01-01
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| Series: | Applied Physics Express |
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| Online Access: | https://doi.org/10.35848/1882-0786/adaf0a |
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| author | Gota Shinohara Tasuku Kayama Ayumu Okui Wataru Oda Atsushi Nishikawa Alexander Loesing Nahoko Kuga Takuya Sasaki Hiroto Sekiguchi |
| author_facet | Gota Shinohara Tasuku Kayama Ayumu Okui Wataru Oda Atsushi Nishikawa Alexander Loesing Nahoko Kuga Takuya Sasaki Hiroto Sekiguchi |
| author_sort | Gota Shinohara |
| collection | DOAJ |
| description | Optogenetics enables precise neural control but is limited by conventional optical fibers in complex networks. We present a hybrid device integrating multi-point micro-light-emitting diodes (MicroLEDs) with neural electrodes for localized light stimulation and simultaneous neural recording. Fabricated via direct bonding, it ensures optimal alignment for high spatial-temporal resolution. The thin MicroLED probes minimize invasiveness while maintaining optical performance. Validated in mouse brain models, the system achieves selective neural activation and recording with minimal thermal effects. This scalable, flexible tool overcomes integration challenges, advancing optogenetic research and opening avenues for exploring neural dynamics and targeted neurological therapies. |
| format | Article |
| id | doaj-art-ff714c50eea04dc8a69b256527758cbc |
| institution | Kabale University |
| issn | 1882-0786 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | Applied Physics Express |
| spelling | doaj-art-ff714c50eea04dc8a69b256527758cbc2025-02-07T14:14:12ZengIOP PublishingApplied Physics Express1882-07862025-01-0118202650110.35848/1882-0786/adaf0aHybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recordingGota Shinohara0Tasuku Kayama1Ayumu Okui2Wataru Oda3Atsushi Nishikawa4Alexander Loesing5Nahoko Kuga6Takuya Sasaki7Hiroto Sekiguchi8https://orcid.org/0000-0002-0692-9975Department of Electrical and Electronic Information Engineering, Toyohashi University of Technology , Toyohashi, Aichi 441-8580, JapanDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University , 6-3 Aramaki-Aoba, Aoba-Ku, Sendai, 980-8578, JapanDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology , Toyohashi, Aichi 441-8580, JapanDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology , Toyohashi, Aichi 441-8580, JapanALLOS Semiconductors GmbH , Trompeterstr. 5, 01069 Dresden, GermanyALLOS Semiconductors GmbH , Trompeterstr. 5, 01069 Dresden, GermanyDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University , 6-3 Aramaki-Aoba, Aoba-Ku, Sendai, 980-8578, JapanDepartment of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University , 6-3 Aramaki-Aoba, Aoba-Ku, Sendai, 980-8578, Japan; Department of Neuropharmacology, Tohoku University School of Medicine , 4-1 Seiryo-machi, Aoba-Ku, Sendai, 980-8575, JapanDepartment of Electrical and Electronic Information Engineering, Toyohashi University of Technology , Toyohashi, Aichi 441-8580, JapanOptogenetics enables precise neural control but is limited by conventional optical fibers in complex networks. We present a hybrid device integrating multi-point micro-light-emitting diodes (MicroLEDs) with neural electrodes for localized light stimulation and simultaneous neural recording. Fabricated via direct bonding, it ensures optimal alignment for high spatial-temporal resolution. The thin MicroLED probes minimize invasiveness while maintaining optical performance. Validated in mouse brain models, the system achieves selective neural activation and recording with minimal thermal effects. This scalable, flexible tool overcomes integration challenges, advancing optogenetic research and opening avenues for exploring neural dynamics and targeted neurological therapies.https://doi.org/10.35848/1882-0786/adaf0amicroLEDGaNoptogeneticsneural probeneural modulationdevice process |
| spellingShingle | Gota Shinohara Tasuku Kayama Ayumu Okui Wataru Oda Atsushi Nishikawa Alexander Loesing Nahoko Kuga Takuya Sasaki Hiroto Sekiguchi Hybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recording Applied Physics Express microLED GaN optogenetics neural probe neural modulation device process |
| title | Hybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recording |
| title_full | Hybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recording |
| title_fullStr | Hybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recording |
| title_full_unstemmed | Hybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recording |
| title_short | Hybrid probe combining MicroLED and neural electrode for precise neural modulation and multi-site recording |
| title_sort | hybrid probe combining microled and neural electrode for precise neural modulation and multi site recording |
| topic | microLED GaN optogenetics neural probe neural modulation device process |
| url | https://doi.org/10.35848/1882-0786/adaf0a |
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