Injury-induced KIF4A neural expression and its role in Schwann cell proliferation suggest a dual function for this kinesin in neural regeneration
Contrary to the adult central nervous system, the peripheral nervous system has an intrinsic ability to regenerate that relies on the expression of regeneration-associated genes, such as some kinesin family members. Kinesins contribute to nerve regeneration through the transport of specific cargo, s...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2026-04-01
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| Series: | Neural Regeneration Research |
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| Online Access: | https://journals.lww.com/10.4103/NRR.NRR-D-24-00232 |
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| author | Patrícia D. Correia Bárbara M. de Sousa Jesús Chato-Astrain Joana Paes de Faria Veronica Estrada João B. Relvas Hans W. Müller Víctor Carriel Frank Bosse Sandra I. Vieira |
| author_facet | Patrícia D. Correia Bárbara M. de Sousa Jesús Chato-Astrain Joana Paes de Faria Veronica Estrada João B. Relvas Hans W. Müller Víctor Carriel Frank Bosse Sandra I. Vieira |
| author_sort | Patrícia D. Correia |
| collection | DOAJ |
| description | Contrary to the adult central nervous system, the peripheral nervous system has an intrinsic ability to regenerate that relies on the expression of regeneration-associated genes, such as some kinesin family members. Kinesins contribute to nerve regeneration through the transport of specific cargo, such as proteins and membrane components, from the cell body towards the axon periphery. We show here that KIF4A, associated with neurodevelopmental disorders and previously believed to be only expressed during development, is also expressed in the adult vertebrate nervous system and up-regulated in injured peripheral nervous system cells. KIF4A is detected both in the cell bodies and regrowing axons of injured neurons, consistent with its function as an axonal transporter of cargoes such as β1-integrin and L1CAM. Our study further demonstrates that KIF4A levels are greatly increased in Schwann cells from injured distal nerve stumps, particularly at a time when they are reprogrammed into an essential proliferative repair phenotype. Moreover, Kif4a mRNA levels were approximately ~6-fold higher in proliferative cultured Schwann cells compared with non-proliferative ones. A hypothesized function for Kif4a in Schwann cell proliferation was further confirmed by Kif4a knockdown, as this significantly reduced Schwann cell proliferation in vitro. Our findings show that KIF4A is expressed in adult vertebrate nervous systems and is up-regulated following peripheral injury. The timing of KIF4A up-regulation, its location during regeneration, and its proliferative role, all suggest a dual role for this protein in neuroregeneration that is worth exploring in the future. |
| format | Article |
| id | doaj-art-ff708d783fc640f2b48c1addb2de9578 |
| institution | Kabale University |
| issn | 1673-5374 1876-7958 |
| language | English |
| publishDate | 2026-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj-art-ff708d783fc640f2b48c1addb2de95782025-08-20T03:31:40ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53741876-79582026-04-012141607162010.4103/NRR.NRR-D-24-00232Injury-induced KIF4A neural expression and its role in Schwann cell proliferation suggest a dual function for this kinesin in neural regenerationPatrícia D. CorreiaBárbara M. de SousaJesús Chato-AstrainJoana Paes de FariaVeronica EstradaJoão B. RelvasHans W. MüllerVíctor CarrielFrank BosseSandra I. VieiraContrary to the adult central nervous system, the peripheral nervous system has an intrinsic ability to regenerate that relies on the expression of regeneration-associated genes, such as some kinesin family members. Kinesins contribute to nerve regeneration through the transport of specific cargo, such as proteins and membrane components, from the cell body towards the axon periphery. We show here that KIF4A, associated with neurodevelopmental disorders and previously believed to be only expressed during development, is also expressed in the adult vertebrate nervous system and up-regulated in injured peripheral nervous system cells. KIF4A is detected both in the cell bodies and regrowing axons of injured neurons, consistent with its function as an axonal transporter of cargoes such as β1-integrin and L1CAM. Our study further demonstrates that KIF4A levels are greatly increased in Schwann cells from injured distal nerve stumps, particularly at a time when they are reprogrammed into an essential proliferative repair phenotype. Moreover, Kif4a mRNA levels were approximately ~6-fold higher in proliferative cultured Schwann cells compared with non-proliferative ones. A hypothesized function for Kif4a in Schwann cell proliferation was further confirmed by Kif4a knockdown, as this significantly reduced Schwann cell proliferation in vitro. Our findings show that KIF4A is expressed in adult vertebrate nervous systems and is up-regulated following peripheral injury. The timing of KIF4A up-regulation, its location during regeneration, and its proliferative role, all suggest a dual role for this protein in neuroregeneration that is worth exploring in the future.https://journals.lww.com/10.4103/NRR.NRR-D-24-00232axonal regrowthkif4 kinesinnerve tissue regenerationneural regenerationperipheral nerve injuryrepairschwann cells |
| spellingShingle | Patrícia D. Correia Bárbara M. de Sousa Jesús Chato-Astrain Joana Paes de Faria Veronica Estrada João B. Relvas Hans W. Müller Víctor Carriel Frank Bosse Sandra I. Vieira Injury-induced KIF4A neural expression and its role in Schwann cell proliferation suggest a dual function for this kinesin in neural regeneration Neural Regeneration Research axonal regrowth kif4 kinesin nerve tissue regeneration neural regeneration peripheral nerve injury repair schwann cells |
| title | Injury-induced KIF4A neural expression and its role in Schwann cell proliferation suggest a dual function for this kinesin in neural regeneration |
| title_full | Injury-induced KIF4A neural expression and its role in Schwann cell proliferation suggest a dual function for this kinesin in neural regeneration |
| title_fullStr | Injury-induced KIF4A neural expression and its role in Schwann cell proliferation suggest a dual function for this kinesin in neural regeneration |
| title_full_unstemmed | Injury-induced KIF4A neural expression and its role in Schwann cell proliferation suggest a dual function for this kinesin in neural regeneration |
| title_short | Injury-induced KIF4A neural expression and its role in Schwann cell proliferation suggest a dual function for this kinesin in neural regeneration |
| title_sort | injury induced kif4a neural expression and its role in schwann cell proliferation suggest a dual function for this kinesin in neural regeneration |
| topic | axonal regrowth kif4 kinesin nerve tissue regeneration neural regeneration peripheral nerve injury repair schwann cells |
| url | https://journals.lww.com/10.4103/NRR.NRR-D-24-00232 |
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