Exploring the association between air pollution and the incidence of liver cancers
Liver cancer, namely hepatocellular carcinoma (HCC), is a major global health concern deeply influenced by environmental factors. Air pollutants emerged as significant contributors to its incidence. This review explores the association between air pollution—specifically particulate matter (PM2.5), i...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324015136 |
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| author | Xin Wu Xin Zhang Xiaopeng Yu Hongyuan Liang Shaoshan Tang Yao Wang |
| author_facet | Xin Wu Xin Zhang Xiaopeng Yu Hongyuan Liang Shaoshan Tang Yao Wang |
| author_sort | Xin Wu |
| collection | DOAJ |
| description | Liver cancer, namely hepatocellular carcinoma (HCC), is a major global health concern deeply influenced by environmental factors. Air pollutants emerged as significant contributors to its incidence. This review explores the association between air pollution—specifically particulate matter (PM2.5), industrial chemicals like vinyl chloride, and benzene—and the increased risk of liver cancer. Mechanistically, air pollutants may cause liver damage by inducing oxidative stress, inflammation, and genetic mutations, contributing to cancer development. Epidemiological evidence from cohort and geographic studies highlights a positive correlation between long-term exposure to air pollutants and elevated incidence and mortality of liver cancer. Furthermore, air pollution has been shown to worsen survival outcomes in liver cancer patients, particularly those diagnosed at early stages. The review emphasizes the need for stricter air quality regulations and relevant research for underlying mechanisms exposed to air pollution. Addressing air pollution exposure could be crucial for reducing liver cancer risks and improving public health outcomes. |
| format | Article |
| id | doaj-art-ff6c0ba829a741a1b5b5be0fc3fe2901 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-ff6c0ba829a741a1b5b5be0fc3fe29012025-02-12T05:29:22ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117437Exploring the association between air pollution and the incidence of liver cancersXin Wu0Xin Zhang1Xiaopeng Yu2Hongyuan Liang3Shaoshan Tang4Yao Wang5Department of General Surgery, Shengjing Hospital of China Medical University, Shengyang, ChinaDepartment of General Surgery, Shengjing Hospital of China Medical University, Shengyang, ChinaOncology Department, Shengjing Hospital of China Medical University, Shengyang, ChinaDepartment of Radiology, Shengjing Hospital of China Medical University, Shengyang, China; Corresponding authors.Department of Ultrasound, Shengjing Hospital of China Medical University, Shengyang, China; Corresponding authors.Department of Ultrasound, Shengjing Hospital of China Medical University, Shengyang, China; Corresponding authors.Liver cancer, namely hepatocellular carcinoma (HCC), is a major global health concern deeply influenced by environmental factors. Air pollutants emerged as significant contributors to its incidence. This review explores the association between air pollution—specifically particulate matter (PM2.5), industrial chemicals like vinyl chloride, and benzene—and the increased risk of liver cancer. Mechanistically, air pollutants may cause liver damage by inducing oxidative stress, inflammation, and genetic mutations, contributing to cancer development. Epidemiological evidence from cohort and geographic studies highlights a positive correlation between long-term exposure to air pollutants and elevated incidence and mortality of liver cancer. Furthermore, air pollution has been shown to worsen survival outcomes in liver cancer patients, particularly those diagnosed at early stages. The review emphasizes the need for stricter air quality regulations and relevant research for underlying mechanisms exposed to air pollution. Addressing air pollution exposure could be crucial for reducing liver cancer risks and improving public health outcomes.http://www.sciencedirect.com/science/article/pii/S0147651324015136Liver cancerAir pollutionOxidative stressInflammationGenotoxicity |
| spellingShingle | Xin Wu Xin Zhang Xiaopeng Yu Hongyuan Liang Shaoshan Tang Yao Wang Exploring the association between air pollution and the incidence of liver cancers Ecotoxicology and Environmental Safety Liver cancer Air pollution Oxidative stress Inflammation Genotoxicity |
| title | Exploring the association between air pollution and the incidence of liver cancers |
| title_full | Exploring the association between air pollution and the incidence of liver cancers |
| title_fullStr | Exploring the association between air pollution and the incidence of liver cancers |
| title_full_unstemmed | Exploring the association between air pollution and the incidence of liver cancers |
| title_short | Exploring the association between air pollution and the incidence of liver cancers |
| title_sort | exploring the association between air pollution and the incidence of liver cancers |
| topic | Liver cancer Air pollution Oxidative stress Inflammation Genotoxicity |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324015136 |
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