G protein-coupled receptor-biased signaling: potential drug discovery to facilitate treatment of metabolic diseases

G protein-coupled receptor-biased signaling: potential drug discovery to facilitate treatment of metabolic diseases

G protein-coupled receptors (GPCRs) are important, potential drug targets for the treatment of metabolic disorders, such as obesity. GPCRs crosstalk with several transducers, including heterotrimeric G proteins, GPCR kinases (GRKs), and β-arrestins. GPCR-biased agonism has raised the potential of no...

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Bibliographic Details
Main Authors: Shengnan Shen, Qiwen Liao, Liwei Gu, Yongping Zhu, Yanqing Liu, Xinwei Zhang, Junzhe Zhang, Qiaoli Shi, Yuxiang Sun, Jigang Wang, Ligen Lin
Format: Article
Language:English
Published: Compuscript Ltd 2024-02-01
Series:Acta Materia Medica
Online Access:https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0041
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