ADVERSE EFFECTS OF LAPROL-604 ON PREGNANT WISTAR RATS
The article reports the results of research Laprol-604-induced effects on general weight, liver weight of pregnant rats, and their food and water consumption. Pregnant Wistar rats were administered 0,125; 1,25 and 12,5 mg/kg Laprol-604 once daily by gavage from the second gestation day (GD) to the t...
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| Format: | Article |
| Language: | English |
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Poltava State Medical University
2017-03-01
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| Series: | Проблеми екології та медицини |
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| Online Access: | https://ecomed-journal.org/index.php/journal/article/view/30 |
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| author | T.M. Popova |
| author_facet | T.M. Popova |
| author_sort | T.M. Popova |
| collection | DOAJ |
| description | The article reports the results of research Laprol-604-induced effects on general weight, liver weight of pregnant rats, and their food and water consumption. Pregnant Wistar rats were administered 0,125; 1,25 and 12,5 mg/kg Laprol-604 once daily by gavage from the second gestation day (GD) to the twentieth GD. Maternal toxicity of Laprol-604 indicated by deficits in weight gain, reduction of food consumption, increase in drinking regimen and largamente of liver weight were observed in 1-rst, 2-nd and 3-rd groups, during pregnancy. The severity Laprol-604 induced effects were dose-dependent. The lag in weight gain was particularly pronounced in the pregnant rats of the 2nd and 3-rd groups. Pregnant rats in the 2nd (1,25mg/kg) and 3-rd (12,5 mg/kg) groups failed to gain any weight until the last week of pregnancy. These weight gain deficits corresponded to significant reductions in food consumption throughout gestation. Liver weights of the Laprol-604 -exposed pregnant rats, except 1-rd group, were different from controls appreciably. It should be noted, while body weight was deficit, the relative liver weight of all Laprol-604 dosage groups was significantly increased. |
| format | Article |
| id | doaj-art-ff677b241f3f438b985475f9d91e769c |
| institution | DOAJ |
| issn | 2073-4662 2519-2302 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | Poltava State Medical University |
| record_format | Article |
| series | Проблеми екології та медицини |
| spelling | doaj-art-ff677b241f3f438b985475f9d91e769c2025-08-20T03:06:13ZengPoltava State Medical UniversityПроблеми екології та медицини2073-46622519-23022017-03-01205-6434630ADVERSE EFFECTS OF LAPROL-604 ON PREGNANT WISTAR RATST.M. Popova0Kharkiv Medical Academy of Postgraduate EducationThe article reports the results of research Laprol-604-induced effects on general weight, liver weight of pregnant rats, and their food and water consumption. Pregnant Wistar rats were administered 0,125; 1,25 and 12,5 mg/kg Laprol-604 once daily by gavage from the second gestation day (GD) to the twentieth GD. Maternal toxicity of Laprol-604 indicated by deficits in weight gain, reduction of food consumption, increase in drinking regimen and largamente of liver weight were observed in 1-rst, 2-nd and 3-rd groups, during pregnancy. The severity Laprol-604 induced effects were dose-dependent. The lag in weight gain was particularly pronounced in the pregnant rats of the 2nd and 3-rd groups. Pregnant rats in the 2nd (1,25mg/kg) and 3-rd (12,5 mg/kg) groups failed to gain any weight until the last week of pregnancy. These weight gain deficits corresponded to significant reductions in food consumption throughout gestation. Liver weights of the Laprol-604 -exposed pregnant rats, except 1-rd group, were different from controls appreciably. It should be noted, while body weight was deficit, the relative liver weight of all Laprol-604 dosage groups was significantly increased.https://ecomed-journal.org/index.php/journal/article/view/30laprol-604, polyols, surfactant, reproductive toxicity, pregnant rat, gestation day, liver weight, food consumption, water intake |
| spellingShingle | T.M. Popova ADVERSE EFFECTS OF LAPROL-604 ON PREGNANT WISTAR RATS Проблеми екології та медицини laprol-604, polyols, surfactant, reproductive toxicity, pregnant rat, gestation day, liver weight, food consumption, water intake |
| title | ADVERSE EFFECTS OF LAPROL-604 ON PREGNANT WISTAR RATS |
| title_full | ADVERSE EFFECTS OF LAPROL-604 ON PREGNANT WISTAR RATS |
| title_fullStr | ADVERSE EFFECTS OF LAPROL-604 ON PREGNANT WISTAR RATS |
| title_full_unstemmed | ADVERSE EFFECTS OF LAPROL-604 ON PREGNANT WISTAR RATS |
| title_short | ADVERSE EFFECTS OF LAPROL-604 ON PREGNANT WISTAR RATS |
| title_sort | adverse effects of laprol 604 on pregnant wistar rats |
| topic | laprol-604, polyols, surfactant, reproductive toxicity, pregnant rat, gestation day, liver weight, food consumption, water intake |
| url | https://ecomed-journal.org/index.php/journal/article/view/30 |
| work_keys_str_mv | AT tmpopova adverseeffectsoflaprol604onpregnantwistarrats |