Activation of interferon-α signaling by resveratrol, genistein and quercetin
Resveratrol, genistein and quercetin from the group of polyphenols from secondary plant metabolites reveal cancer preventive and antivirus effects realized via their pleiotropic influence on the different macromolecules in cells. These compounds can interact with DNA without the formation of covalen...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Russian Academy of Sciences, Tomsk National Research Medical Center
2019-02-01
|
| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/959 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849699954390466560 |
|---|---|
| author | O. A. Vlasova A. A. Borunova A. Safina I. V. Smetanina E. A. Lesovaya G. A. Belitsky T. N. Zabotina K. Gurova K. I. Kirsanov M. G. Yakubovskaya |
| author_facet | O. A. Vlasova A. A. Borunova A. Safina I. V. Smetanina E. A. Lesovaya G. A. Belitsky T. N. Zabotina K. Gurova K. I. Kirsanov M. G. Yakubovskaya |
| author_sort | O. A. Vlasova |
| collection | DOAJ |
| description | Resveratrol, genistein and quercetin from the group of polyphenols from secondary plant metabolites reveal cancer preventive and antivirus effects realized via their pleiotropic influence on the different macromolecules in cells. These compounds can interact with DNA without the formation of covalent bonds. This process is usually followed by changes in spatial, physical-chemical and structural DNA characteristics that can result in disfunction of DNA metabolism enzymes and chromatin destabilization. Similar effects were described for anticancer drug Curaxine CBL0137 in association with activation of interferon-α signaling. We demonstrated dose-dependent stimulating effects of resveratrol, genistein and quercetin on interferon-α signaling using HeLa cells expressed mCherry protein with interferon-stimulated response elements (ISRE) in promoter. Furthermore, it was shown by live-cell fluorescent microscopy in HT1080 cells with mCherry-labeled histone H1.5 that described polyphenols induced the redistribution of this linker histone in cell nuclei. The data obtained suggest an existence of DNA-dependent mechanism of anticancer effects of plant polyphenols and a need for further study of crosslinks between the polyphenols’ influence on chromatin structure and the changes in genome function, in particular, induction of interferon- interferon-α signaling. |
| format | Article |
| id | doaj-art-ff5ede31217f4c6c8026d2f06ad0141e |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2019-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-ff5ede31217f4c6c8026d2f06ad0141e2025-08-20T03:18:26ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682019-02-01181505510.21294/1814-4861-2019-18-1-50-55611Activation of interferon-α signaling by resveratrol, genistein and quercetinO. A. Vlasova0A. A. Borunova1A. Safina2I. V. Smetanina3E. A. Lesovaya4G. A. Belitsky5T. N. Zabotina6K. Gurova7K. I. Kirsanov8M. G. Yakubovskaya9N.N. Blokhin National Medical Research Center of OncologyN.N. Blokhin National Medical Research Center of OncologyRoswell Park Cancer CenterN.N. Blokhin National Medical Research Center of OncologyN.N. Blokhin National Medical Research Center of Oncology; I.P. Pavlov Ryazan State Medical UniversityN.N. Blokhin National Medical Research Center of OncologyN.N. Blokhin National Medical Research Center of OncologyRoswell Park Cancer CenterN.N. Blokhin National Medical Research Center of Oncology; RUDN UniversityN.N. Blokhin National Medical Research Center of OncologyResveratrol, genistein and quercetin from the group of polyphenols from secondary plant metabolites reveal cancer preventive and antivirus effects realized via their pleiotropic influence on the different macromolecules in cells. These compounds can interact with DNA without the formation of covalent bonds. This process is usually followed by changes in spatial, physical-chemical and structural DNA characteristics that can result in disfunction of DNA metabolism enzymes and chromatin destabilization. Similar effects were described for anticancer drug Curaxine CBL0137 in association with activation of interferon-α signaling. We demonstrated dose-dependent stimulating effects of resveratrol, genistein and quercetin on interferon-α signaling using HeLa cells expressed mCherry protein with interferon-stimulated response elements (ISRE) in promoter. Furthermore, it was shown by live-cell fluorescent microscopy in HT1080 cells with mCherry-labeled histone H1.5 that described polyphenols induced the redistribution of this linker histone in cell nuclei. The data obtained suggest an existence of DNA-dependent mechanism of anticancer effects of plant polyphenols and a need for further study of crosslinks between the polyphenols’ influence on chromatin structure and the changes in genome function, in particular, induction of interferon- interferon-α signaling.https://www.siboncoj.ru/jour/article/view/959plant polyphenolsresveratrolgenisteinquercetininterferon-αhistone н1macromoleculesfluorescence microscopymetabolism enzymes |
| spellingShingle | O. A. Vlasova A. A. Borunova A. Safina I. V. Smetanina E. A. Lesovaya G. A. Belitsky T. N. Zabotina K. Gurova K. I. Kirsanov M. G. Yakubovskaya Activation of interferon-α signaling by resveratrol, genistein and quercetin Сибирский онкологический журнал plant polyphenols resveratrol genistein quercetin interferon-α histone н1 macromolecules fluorescence microscopy metabolism enzymes |
| title | Activation of interferon-α signaling by resveratrol, genistein and quercetin |
| title_full | Activation of interferon-α signaling by resveratrol, genistein and quercetin |
| title_fullStr | Activation of interferon-α signaling by resveratrol, genistein and quercetin |
| title_full_unstemmed | Activation of interferon-α signaling by resveratrol, genistein and quercetin |
| title_short | Activation of interferon-α signaling by resveratrol, genistein and quercetin |
| title_sort | activation of interferon α signaling by resveratrol genistein and quercetin |
| topic | plant polyphenols resveratrol genistein quercetin interferon-α histone н1 macromolecules fluorescence microscopy metabolism enzymes |
| url | https://www.siboncoj.ru/jour/article/view/959 |
| work_keys_str_mv | AT oavlasova activationofinterferonasignalingbyresveratrolgenisteinandquercetin AT aaborunova activationofinterferonasignalingbyresveratrolgenisteinandquercetin AT asafina activationofinterferonasignalingbyresveratrolgenisteinandquercetin AT ivsmetanina activationofinterferonasignalingbyresveratrolgenisteinandquercetin AT ealesovaya activationofinterferonasignalingbyresveratrolgenisteinandquercetin AT gabelitsky activationofinterferonasignalingbyresveratrolgenisteinandquercetin AT tnzabotina activationofinterferonasignalingbyresveratrolgenisteinandquercetin AT kgurova activationofinterferonasignalingbyresveratrolgenisteinandquercetin AT kikirsanov activationofinterferonasignalingbyresveratrolgenisteinandquercetin AT mgyakubovskaya activationofinterferonasignalingbyresveratrolgenisteinandquercetin |