Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction: A Case Report and Review of the Literature
Malignant fibrous histiocytoma (MFH) is the most common sarcoma found in adults. We discuss a case of inflammatory MFH of dermal/epidermal origin presenting with a severe leukemoid reaction (LR). A 60 years old white male presented to hematology/oncology clinic complaining of mild shortness of breat...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/798629 |
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| _version_ | 1849469004186386432 |
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| author | Jorge Hurtado-Cordovi Boris Avezbakiyev Marianne Frieri Lester Freedman Wondwoosen Gebre |
| author_facet | Jorge Hurtado-Cordovi Boris Avezbakiyev Marianne Frieri Lester Freedman Wondwoosen Gebre |
| author_sort | Jorge Hurtado-Cordovi |
| collection | DOAJ |
| description | Malignant fibrous histiocytoma (MFH) is the most common sarcoma found in adults. We discuss a case of inflammatory MFH of dermal/epidermal origin presenting with a severe leukemoid reaction (LR). A 60 years old white male presented to hematology/oncology clinic complaining of mild shortness of breath on exertion. Past medical history was remarkable for removal of a left upper extremity necrotic mass 4.4 × 3 × 3 cm. Microscopy of the specimen showed clear surgical margin, and tumor cells restricted to the dermis without lymphovascular invasion. Immunohistochemestry was positive for CD 68 and CD 99. Chest x-ray was negative for metastatic disease. White blood cell count was 109.4 k/mm3 with 24 k/mm3 band neutrophils, and absolute neutrophil count of 69 k/mm3. CT scan of the thorax revealed numerous bilateral pulmonary nodules suspicious for metastasis. Based on these findings patient was diagnosed with metastatic cutaneous IMFH associated with a LR. Following review of medical literature, this appears to be the first reported case of inflammatory cutaneous MFH associated with LR. This histological variant is rare, and carries a poor prognosis. Thus, we would like to emphasize the need for investigating alternative therapies capable of improving the survival of these patients. |
| format | Article |
| id | doaj-art-ff5c8f35489e4c0eb295a3c4e26b3fac |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-ff5c8f35489e4c0eb295a3c4e26b3fac2025-08-20T03:25:40ZengWileyCase Reports in Medicine1687-96271687-96352012-01-01201210.1155/2012/798629798629Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction: A Case Report and Review of the LiteratureJorge Hurtado-Cordovi0Boris Avezbakiyev1Marianne Frieri2Lester Freedman3Wondwoosen Gebre4Nassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USANassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USANassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USADivision of Hematology/Oncology, Nassau University Medical Center and North Shore-Long Island Jewish Health System, East Meadow, NY 11554, USANassau University Medical Center, 2201 Hempstead Turnpike, East Meadow, NY 11554, USAMalignant fibrous histiocytoma (MFH) is the most common sarcoma found in adults. We discuss a case of inflammatory MFH of dermal/epidermal origin presenting with a severe leukemoid reaction (LR). A 60 years old white male presented to hematology/oncology clinic complaining of mild shortness of breath on exertion. Past medical history was remarkable for removal of a left upper extremity necrotic mass 4.4 × 3 × 3 cm. Microscopy of the specimen showed clear surgical margin, and tumor cells restricted to the dermis without lymphovascular invasion. Immunohistochemestry was positive for CD 68 and CD 99. Chest x-ray was negative for metastatic disease. White blood cell count was 109.4 k/mm3 with 24 k/mm3 band neutrophils, and absolute neutrophil count of 69 k/mm3. CT scan of the thorax revealed numerous bilateral pulmonary nodules suspicious for metastasis. Based on these findings patient was diagnosed with metastatic cutaneous IMFH associated with a LR. Following review of medical literature, this appears to be the first reported case of inflammatory cutaneous MFH associated with LR. This histological variant is rare, and carries a poor prognosis. Thus, we would like to emphasize the need for investigating alternative therapies capable of improving the survival of these patients.http://dx.doi.org/10.1155/2012/798629 |
| spellingShingle | Jorge Hurtado-Cordovi Boris Avezbakiyev Marianne Frieri Lester Freedman Wondwoosen Gebre Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction: A Case Report and Review of the Literature Case Reports in Medicine |
| title | Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction: A Case Report and Review of the Literature |
| title_full | Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction: A Case Report and Review of the Literature |
| title_fullStr | Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction: A Case Report and Review of the Literature |
| title_full_unstemmed | Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction: A Case Report and Review of the Literature |
| title_short | Cutaneous Inflammatory Malignant Fibrous Histiocytoma Presenting with a Leukemoid Reaction: A Case Report and Review of the Literature |
| title_sort | cutaneous inflammatory malignant fibrous histiocytoma presenting with a leukemoid reaction a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2012/798629 |
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