Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy
Liquid biopsy has emerged as a valuable clinical tool due to its non-invasive nature and real-time molecular profiling capabilities. Transfer RNA-derived small RNAs (tsRNAs) are a group of small non-coding RNAs generated from mature tRNAs or tRNA precursors. Recently, increasing studies have reporte...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-09-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304225000972 |
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| author | Qinglin Wang Zehao Pan Si Liang Yuanjian Shi Gaochao Dong Lin Xu Qixing Mao Feng Jiang |
| author_facet | Qinglin Wang Zehao Pan Si Liang Yuanjian Shi Gaochao Dong Lin Xu Qixing Mao Feng Jiang |
| author_sort | Qinglin Wang |
| collection | DOAJ |
| description | Liquid biopsy has emerged as a valuable clinical tool due to its non-invasive nature and real-time molecular profiling capabilities. Transfer RNA-derived small RNAs (tsRNAs) are a group of small non-coding RNAs generated from mature tRNAs or tRNA precursors. Recently, increasing studies have reported tsRNAs' potential to serve as promising biomarkers in various diseases, especially cancers. Notably, tsRNAs can be detected in various kinds of body fluids, such as seminal fluid plasma, blood plasma, saliva, and urine, and have been demonstrated to exist stably in body fluids. In this mini-review, we will summarize the recent discoveries on the role of tsRNAs in body fluids as biomarkers, hoping to provide new insights for disease diagnosis and therapeutic strategies. |
| format | Article |
| id | doaj-art-ff57fec0988d4b2cabf9ccff550b22de |
| institution | DOAJ |
| issn | 2352-3042 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj-art-ff57fec0988d4b2cabf9ccff550b22de2025-08-20T03:15:02ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422025-09-0112510160810.1016/j.gendis.2025.101608Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsyQinglin Wang0Zehao Pan1Si Liang2Yuanjian Shi3Gaochao Dong4Lin Xu5Qixing Mao6Feng Jiang7Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210009, China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu 210009, ChinaDepartment of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210009, China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu 210009, ChinaDepartment of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210009, China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu 210009, ChinaDepartment of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210009, China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu 210009, ChinaDepartment of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210009, China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu 210009, ChinaDepartment of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210009, China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu 210009, China; Corresponding author. Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210009, China.Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210009, China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu 210009, China; Corresponding author. Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu 210009, China.Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210009, China; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Cancer Institute of Jiangsu Province, Nanjing, Jiangsu 210009, China; Corresponding author. Department of Thoracic Surgery, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu 210009, China.Liquid biopsy has emerged as a valuable clinical tool due to its non-invasive nature and real-time molecular profiling capabilities. Transfer RNA-derived small RNAs (tsRNAs) are a group of small non-coding RNAs generated from mature tRNAs or tRNA precursors. Recently, increasing studies have reported tsRNAs' potential to serve as promising biomarkers in various diseases, especially cancers. Notably, tsRNAs can be detected in various kinds of body fluids, such as seminal fluid plasma, blood plasma, saliva, and urine, and have been demonstrated to exist stably in body fluids. In this mini-review, we will summarize the recent discoveries on the role of tsRNAs in body fluids as biomarkers, hoping to provide new insights for disease diagnosis and therapeutic strategies.http://www.sciencedirect.com/science/article/pii/S2352304225000972BiomarkerCancerDiagnosisLiquid biopsytsRNA |
| spellingShingle | Qinglin Wang Zehao Pan Si Liang Yuanjian Shi Gaochao Dong Lin Xu Qixing Mao Feng Jiang Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy Genes and Diseases Biomarker Cancer Diagnosis Liquid biopsy tsRNA |
| title | Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy |
| title_full | Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy |
| title_fullStr | Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy |
| title_full_unstemmed | Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy |
| title_short | Transfer RNA-derived small RNAs (tsRNAs): A rising star in liquid biopsy |
| title_sort | transfer rna derived small rnas tsrnas a rising star in liquid biopsy |
| topic | Biomarker Cancer Diagnosis Liquid biopsy tsRNA |
| url | http://www.sciencedirect.com/science/article/pii/S2352304225000972 |
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