Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia
Background. Nontransfusion dependent thalassemia (NTDT) is a milder form of thalassemia that does not require regular transfusion. It is associated with many complications, which differ from that found in transfusion-dependent thalassemia (TDT). Currently available information is mostly derived from...
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| Language: | English |
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Wiley
2015-01-01
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| Series: | Anemia |
| Online Access: | http://dx.doi.org/10.1155/2015/793025 |
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| author | Poramed Winichakoon Adisak Tantiworawit Thanawat Rattanathammethee Sasinee Hantrakool Chatree Chai-Adisaksopha Ekarat Rattarittamrong Lalita Norasetthada Pimlak Charoenkwan |
| author_facet | Poramed Winichakoon Adisak Tantiworawit Thanawat Rattanathammethee Sasinee Hantrakool Chatree Chai-Adisaksopha Ekarat Rattarittamrong Lalita Norasetthada Pimlak Charoenkwan |
| author_sort | Poramed Winichakoon |
| collection | DOAJ |
| description | Background. Nontransfusion dependent thalassemia (NTDT) is a milder form of thalassemia that does not require regular transfusion. It is associated with many complications, which differ from that found in transfusion-dependent thalassemia (TDT). Currently available information is mostly derived from beta-NTDT; consequently, more data is needed to describe complications found in the alpha-NTDT form of this disease. Methods. We retrospectively reviewed the medical records of NTDT patients from January 2012 to December 2013. Complications related to thalassemia were reviewed and compared. Results. One hundred patients included 60 females with a median age of 38 years. The majority (54 patients) had alpha-thalassemia. Overall, 83 patients had one or more complications. The three most common complications were cholelithiasis (35%), abnormal liver function (29%), and extramedullary hematopoiesis (EMH) (25%). EMH, cardiomyopathy, cholelithiasis, and pulmonary hypertension were more commonly seen in beta-thalassemia. Osteoporosis was the only complication that was more common in alpha-thalassemia. The risk factors significantly related to EMH were beta-thalassemia type and hemoglobin < 8 g/dL. The risk factors related to osteoporosis were female gender and age > 40 years. Iron overload (ferritin > 800 ng/mL) was the only risk factor for abnormal liver function. Conclusion. The prevalence of alpha-NTDT complications was lower and different from beta-thalassemia. |
| format | Article |
| id | doaj-art-ff50c9460ecc4c809fe4d0caa4ef6f53 |
| institution | Kabale University |
| issn | 2090-1267 2090-1275 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anemia |
| spelling | doaj-art-ff50c9460ecc4c809fe4d0caa4ef6f532025-08-20T03:25:40ZengWileyAnemia2090-12672090-12752015-01-01201510.1155/2015/793025793025Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-ThalassemiaPoramed Winichakoon0Adisak Tantiworawit1Thanawat Rattanathammethee2Sasinee Hantrakool3Chatree Chai-Adisaksopha4Ekarat Rattarittamrong5Lalita Norasetthada6Pimlak Charoenkwan7Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Intravaroros Road, A. Muang, Chiang Mai 50200, ThailandDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Intravaroros Road, A. Muang, Chiang Mai 50200, ThailandDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Intravaroros Road, A. Muang, Chiang Mai 50200, ThailandDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Intravaroros Road, A. Muang, Chiang Mai 50200, ThailandDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Intravaroros Road, A. Muang, Chiang Mai 50200, ThailandDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Intravaroros Road, A. Muang, Chiang Mai 50200, ThailandDivision of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, 110 Intravaroros Road, A. Muang, Chiang Mai 50200, ThailandDivision of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, 110 Intravaroros Road, A. Muang, Chiang Mai 50200, ThailandBackground. Nontransfusion dependent thalassemia (NTDT) is a milder form of thalassemia that does not require regular transfusion. It is associated with many complications, which differ from that found in transfusion-dependent thalassemia (TDT). Currently available information is mostly derived from beta-NTDT; consequently, more data is needed to describe complications found in the alpha-NTDT form of this disease. Methods. We retrospectively reviewed the medical records of NTDT patients from January 2012 to December 2013. Complications related to thalassemia were reviewed and compared. Results. One hundred patients included 60 females with a median age of 38 years. The majority (54 patients) had alpha-thalassemia. Overall, 83 patients had one or more complications. The three most common complications were cholelithiasis (35%), abnormal liver function (29%), and extramedullary hematopoiesis (EMH) (25%). EMH, cardiomyopathy, cholelithiasis, and pulmonary hypertension were more commonly seen in beta-thalassemia. Osteoporosis was the only complication that was more common in alpha-thalassemia. The risk factors significantly related to EMH were beta-thalassemia type and hemoglobin < 8 g/dL. The risk factors related to osteoporosis were female gender and age > 40 years. Iron overload (ferritin > 800 ng/mL) was the only risk factor for abnormal liver function. Conclusion. The prevalence of alpha-NTDT complications was lower and different from beta-thalassemia.http://dx.doi.org/10.1155/2015/793025 |
| spellingShingle | Poramed Winichakoon Adisak Tantiworawit Thanawat Rattanathammethee Sasinee Hantrakool Chatree Chai-Adisaksopha Ekarat Rattarittamrong Lalita Norasetthada Pimlak Charoenkwan Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia Anemia |
| title | Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia |
| title_full | Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia |
| title_fullStr | Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia |
| title_full_unstemmed | Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia |
| title_short | Prevalence and Risk Factors for Complications in Patients with Nontransfusion Dependent Alpha- and Beta-Thalassemia |
| title_sort | prevalence and risk factors for complications in patients with nontransfusion dependent alpha and beta thalassemia |
| url | http://dx.doi.org/10.1155/2015/793025 |
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