Multi-omics and AI-driven immune subtyping to optimize neoantigen-based vaccines for colorectal cancer

Multi-omics and AI-driven immune subtyping to optimize neoantigen-based vaccines for colorectal cancer

Abstract Colorectal cancer (CRC) presents significant challenges due to limited targeted therapeutic options. This study integrates multi-omics analysis and AI to identify tumor antigens and immune gene targets for personalized immunotherapy. Using TCGA, differential expression and mutation analysis...

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Bibliographic Details
Main Authors: Karthick Vasudevan, Dhanushkumar T, Sripad Rama Hebbar, Prasanna Kumar Selvam, Majji Rambabu, Krishnan Anbarasu, Karunakaran Rohini
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Neoantigens
Machine learning
Immune subtypes
Tumor antigens
Immunotherapy
Online Access:https://doi.org/10.1038/s41598-025-01680-1
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https://doi.org/10.1038/s41598-025-01680-1

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