Selective Incision of the α-N5-Methyl-Formamidopyrimidine Anomer by Escherichia coli Endonuclease IV

Selective Incision of the α-N5-Methyl-Formamidopyrimidine Anomer by Escherichia coli Endonuclease IV

Formamidopyrimidines (Fapy) lesions result from ring opening of the imidazole portion of purines. Fapy lesions can isomerize from the natural β-anomeric stereochemistry to the α-configuration. We have unambiguously demonstrated that the α-methyl-Fapy-dG (MeFapy-dG) lesion is a substrate for Escheric...

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Bibliographic Details
Main Authors: Plamen P. Christov, Surajit Banerjee, Michael P. Stone, Carmelo J. Rizzo
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Journal of Nucleic Acids
Online Access:http://dx.doi.org/10.4061/2010/850234
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