Synthesis of novel benzo fused bridged azaheterocycles through the reaction of chalcone with hydrazone
We reported a direct construction of aza-[3.3.1]-bicycles from 2-aminochalcones and hydrazone. Notably, this method formed a potentially biologically active bridged structure containing multiple nitrogen atoms under mild conditions with high yields. This reaction exhibits broad substrate scope and e...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Tetrahedron Chem |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666951X2500004X |
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| author | Congyang Li Ruochen Pang Weiwu Ren |
| author_facet | Congyang Li Ruochen Pang Weiwu Ren |
| author_sort | Congyang Li |
| collection | DOAJ |
| description | We reported a direct construction of aza-[3.3.1]-bicycles from 2-aminochalcones and hydrazone. Notably, this method formed a potentially biologically active bridged structure containing multiple nitrogen atoms under mild conditions with high yields. This reaction exhibits broad substrate scope and excellent functional group tolerance. This is a new type of benzo fused bridged azaheterocycles, which will be beneficial for further research on this skeleton. |
| format | Article |
| id | doaj-art-ff4cc2d5bc874ce183b4993c62c6ec9d |
| institution | Kabale University |
| issn | 2666-951X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Tetrahedron Chem |
| spelling | doaj-art-ff4cc2d5bc874ce183b4993c62c6ec9d2025-01-31T05:12:35ZengElsevierTetrahedron Chem2666-951X2025-03-0113100122Synthesis of novel benzo fused bridged azaheterocycles through the reaction of chalcone with hydrazoneCongyang Li0Ruochen Pang1Weiwu Ren2Molecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, 266003, ChinaMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, 266003, ChinaMolecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China; Laboratory for Marine Drugs and Bioproducts, Qingdao Marine Science and Technology Center, Qingdao, 266237, China; Corresponding author. Molecular Synthesis Center & Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao, 266003, ChinaWe reported a direct construction of aza-[3.3.1]-bicycles from 2-aminochalcones and hydrazone. Notably, this method formed a potentially biologically active bridged structure containing multiple nitrogen atoms under mild conditions with high yields. This reaction exhibits broad substrate scope and excellent functional group tolerance. This is a new type of benzo fused bridged azaheterocycles, which will be beneficial for further research on this skeleton.http://www.sciencedirect.com/science/article/pii/S2666951X2500004XFused bridged azaheterocycles2-Aminochalcone hydrazoneCyclization reactionAza-[3.3.1]-bicycle |
| spellingShingle | Congyang Li Ruochen Pang Weiwu Ren Synthesis of novel benzo fused bridged azaheterocycles through the reaction of chalcone with hydrazone Tetrahedron Chem Fused bridged azaheterocycles 2-Aminochalcone hydrazone Cyclization reaction Aza-[3.3.1]-bicycle |
| title | Synthesis of novel benzo fused bridged azaheterocycles through the reaction of chalcone with hydrazone |
| title_full | Synthesis of novel benzo fused bridged azaheterocycles through the reaction of chalcone with hydrazone |
| title_fullStr | Synthesis of novel benzo fused bridged azaheterocycles through the reaction of chalcone with hydrazone |
| title_full_unstemmed | Synthesis of novel benzo fused bridged azaheterocycles through the reaction of chalcone with hydrazone |
| title_short | Synthesis of novel benzo fused bridged azaheterocycles through the reaction of chalcone with hydrazone |
| title_sort | synthesis of novel benzo fused bridged azaheterocycles through the reaction of chalcone with hydrazone |
| topic | Fused bridged azaheterocycles 2-Aminochalcone hydrazone Cyclization reaction Aza-[3.3.1]-bicycle |
| url | http://www.sciencedirect.com/science/article/pii/S2666951X2500004X |
| work_keys_str_mv | AT congyangli synthesisofnovelbenzofusedbridgedazaheterocyclesthroughthereactionofchalconewithhydrazone AT ruochenpang synthesisofnovelbenzofusedbridgedazaheterocyclesthroughthereactionofchalconewithhydrazone AT weiwuren synthesisofnovelbenzofusedbridgedazaheterocyclesthroughthereactionofchalconewithhydrazone |