Synthesis of novel benzo fused bridged azaheterocycles through the reaction of chalcone with hydrazone
We reported a direct construction of aza-[3.3.1]-bicycles from 2-aminochalcones and hydrazone. Notably, this method formed a potentially biologically active bridged structure containing multiple nitrogen atoms under mild conditions with high yields. This reaction exhibits broad substrate scope and e...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-03-01
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| Series: | Tetrahedron Chem |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666951X2500004X |
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| Summary: | We reported a direct construction of aza-[3.3.1]-bicycles from 2-aminochalcones and hydrazone. Notably, this method formed a potentially biologically active bridged structure containing multiple nitrogen atoms under mild conditions with high yields. This reaction exhibits broad substrate scope and excellent functional group tolerance. This is a new type of benzo fused bridged azaheterocycles, which will be beneficial for further research on this skeleton. |
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| ISSN: | 2666-951X |