Nanomaterial-based encapsulation of biochemicals for targeted sepsis therapy
Sepsis is a life-threatening condition characterized by complex pathophysiology, including dysregulated immune responses, excessive inflammation, and oxidative stress, often leading to multi-organ failure and high mortality rates. Traditional therapies, such as antibiotics and anti-inflammatory agen...
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Elsevier
2025-08-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425006246 |
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| author | Zhiwei Li Bin Luo Yisheng Chen Lingling Wang Yezi Liu Jintong Jia Mengsi Chen Shuting Yang Haojun Shi Lihua Dai Lei Huang Changmin Wang Jia Liu |
| author_facet | Zhiwei Li Bin Luo Yisheng Chen Lingling Wang Yezi Liu Jintong Jia Mengsi Chen Shuting Yang Haojun Shi Lihua Dai Lei Huang Changmin Wang Jia Liu |
| author_sort | Zhiwei Li |
| collection | DOAJ |
| description | Sepsis is a life-threatening condition characterized by complex pathophysiology, including dysregulated immune responses, excessive inflammation, and oxidative stress, often leading to multi-organ failure and high mortality rates. Traditional therapies, such as antibiotics and anti-inflammatory agents, face significant limitations due to issues like drug resistance and inadequate immune modulation. Recent advancements in nanotechnology have introduced innovative solutions by leveraging nanomaterial-based encapsulation systems for bioactive substances, including antioxidants, anti-inflammatory agents, and immunomodulators. These systems enhance the stability, bioavailability, and targeted delivery of therapeutic agents, addressing critical challenges in sepsis management. Key nanocarriers, such as lipid nanoparticles, polymer-based systems, and plant-derived exosomes, offer controlled release mechanisms and precise targeting capabilities, enabling superior therapeutic outcomes. Moreover, nanomaterials' multifunctional properties allow for simultaneous modulation of oxidative stress, inflammation, and immune responses, presenting a synergistic approach to sepsis therapy. However, challenges persist, including the potential toxicity of nanomaterials, scalability of production, and hurdles in clinical translation. This review comprehensively explores the transformative potential of nanotechnology in reshaping sepsis treatment strategies, highlighting its role in advancing precision medicine and its prospects for overcoming current therapeutic barriers. |
| format | Article |
| id | doaj-art-ff49719d9f854c559e5e0d8d64f62b34 |
| institution | DOAJ |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-ff49719d9f854c559e5e0d8d64f62b342025-08-20T03:16:57ZengElsevierMaterials Today Bio2590-00642025-08-013310205410.1016/j.mtbio.2025.102054Nanomaterial-based encapsulation of biochemicals for targeted sepsis therapyZhiwei Li0Bin Luo1Yisheng Chen2Lingling Wang3Yezi Liu4Jintong Jia5Mengsi Chen6Shuting Yang7Haojun Shi8Lihua Dai9Lei Huang10Changmin Wang11Jia Liu12Clinical Laboratory Center, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi, Xinjiang, 830001, ChinaClinical Laboratory Center, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi, Xinjiang, 830001, ChinaFujian Key Laboratory of Toxicant and Drug Toxicology, Medical College, Ningde Municipal Hospital, Ningde Normal University, Ningde, China; Ningde Clinical Medical College, Fujian Medical University, Ningde, Fujian Province, China; Department of Vascular Surgery, Ningde Municipal Hospital, Ningde Normal University, Ningde, Fujian Province, China; Department of Neurosurgery, Department of Physiology and Pharmacology, Department of Neurosurgery and Anesthesiology, School of Medicine, Loma Linda University, Risley Hall, Room 219, 11041 Campus Street, Loma Linda, CA, 92354, USA; Precision Medicine Center, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi, Xinjiang, 830001, China; Corresponding authors. Fujian Key Laboratory of Toxicant and Drug Toxicology, Medical College, Ningde Municipal Hospital, Ningde Normal University, Fujian Medical University, China.Clinical Laboratory Center, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi, Xinjiang, 830001, ChinaClinical Laboratory Center, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi, Xinjiang, 830001, ChinaShihezi University School of Medicine, North 2nd Road, Shihezi, Xinjiang, 832000, ChinaShihezi University School of Medicine, North 2nd Road, Shihezi, Xinjiang, 832000, ChinaClinical Laboratory Center, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi, Xinjiang, 830001, ChinaFaculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macao Special Administrative Region of ChinaEmergency and Intensive Care Unit, Shidong Hospital affiliated to University of Shanghai for Science and Technology, Shanghai, ChinaDepartment of Molecular Cell and Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01605, USA; Corresponding author. Department of Molecular Cell and Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA, 01605, USA.Clinical Laboratory Center, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi, Xinjiang, 830001, China; Corresponding authors. Clinical Laboratory Center, The People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi, Xinjiang, 830001, ChinaPrecision Medicine Center, People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi, Xinjiang, 830001, China; Corresponding author. Precision Medicine Center, The People's Hospital of Xinjiang Uygur Autonomous Region, No. 91 Tianchi Road, Urumqi, Xinjiang, 830001, ChinaSepsis is a life-threatening condition characterized by complex pathophysiology, including dysregulated immune responses, excessive inflammation, and oxidative stress, often leading to multi-organ failure and high mortality rates. Traditional therapies, such as antibiotics and anti-inflammatory agents, face significant limitations due to issues like drug resistance and inadequate immune modulation. Recent advancements in nanotechnology have introduced innovative solutions by leveraging nanomaterial-based encapsulation systems for bioactive substances, including antioxidants, anti-inflammatory agents, and immunomodulators. These systems enhance the stability, bioavailability, and targeted delivery of therapeutic agents, addressing critical challenges in sepsis management. Key nanocarriers, such as lipid nanoparticles, polymer-based systems, and plant-derived exosomes, offer controlled release mechanisms and precise targeting capabilities, enabling superior therapeutic outcomes. Moreover, nanomaterials' multifunctional properties allow for simultaneous modulation of oxidative stress, inflammation, and immune responses, presenting a synergistic approach to sepsis therapy. However, challenges persist, including the potential toxicity of nanomaterials, scalability of production, and hurdles in clinical translation. This review comprehensively explores the transformative potential of nanotechnology in reshaping sepsis treatment strategies, highlighting its role in advancing precision medicine and its prospects for overcoming current therapeutic barriers.http://www.sciencedirect.com/science/article/pii/S2590006425006246NanomaterialsSepsisTargeted drug deliveryNanocarriersPrecision medicine |
| spellingShingle | Zhiwei Li Bin Luo Yisheng Chen Lingling Wang Yezi Liu Jintong Jia Mengsi Chen Shuting Yang Haojun Shi Lihua Dai Lei Huang Changmin Wang Jia Liu Nanomaterial-based encapsulation of biochemicals for targeted sepsis therapy Materials Today Bio Nanomaterials Sepsis Targeted drug delivery Nanocarriers Precision medicine |
| title | Nanomaterial-based encapsulation of biochemicals for targeted sepsis therapy |
| title_full | Nanomaterial-based encapsulation of biochemicals for targeted sepsis therapy |
| title_fullStr | Nanomaterial-based encapsulation of biochemicals for targeted sepsis therapy |
| title_full_unstemmed | Nanomaterial-based encapsulation of biochemicals for targeted sepsis therapy |
| title_short | Nanomaterial-based encapsulation of biochemicals for targeted sepsis therapy |
| title_sort | nanomaterial based encapsulation of biochemicals for targeted sepsis therapy |
| topic | Nanomaterials Sepsis Targeted drug delivery Nanocarriers Precision medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425006246 |
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