The association of maternal thyroid function with placental hemodynamics during pregnancy
We examined 164 pregnant women who were divided into three groups. Group I included 76 pregnant women (46.4 %) with euthyroid goiter of I–II degree. Group II consisted of 63 pregnant women (38.4 %) with subclinical hypothyroidism and diffuse thyroid goiter of I–II degree. Group III was the controls...
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Zaslavsky O.Yu.
2024-06-01
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| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
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| Online Access: | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1412 |
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| author | O.S. Paienok R.G. Protsiuk A.V. Paienok B.V. Zadorozhna B.R. Hrytsyshyn S.V. Ihnatovych |
| author_facet | O.S. Paienok R.G. Protsiuk A.V. Paienok B.V. Zadorozhna B.R. Hrytsyshyn S.V. Ihnatovych |
| author_sort | O.S. Paienok |
| collection | DOAJ |
| description | We examined 164 pregnant women who were divided into three groups. Group I included 76 pregnant women (46.4 %) with euthyroid goiter of I–II degree. Group II consisted of 63 pregnant women (38.4 %) with subclinical hypothyroidism and diffuse thyroid goiter of I–II degree. Group III was the controls and consisted of 25 (15.2 %) pregnant women without thyroid pathology. The placenta was studied with the characteristics of ultrasound placentography, placental maturation disorders, the area and localization were determined, and pathological changes in the placental tissue were detected. Changes in the systolic-diastolic ratio in the uterine arteries and umbilical cord arteries were assessed, the resistance index in the uterine arteries, the pulsatile index in the fetal aorta and middle cerebral artery were determined using the method of color Doppler mapping of blood flow in the mother-placenta-fetus system. Study of the echographic picture of structural changes in the placenta revealed a significant impairment of its maturation, especially in the group with euthyroidism. Ultrasound screening revealed that in every second pregnant woman with thyroid disease, the condition of the placenta did not correspond to the gestational age, there were swelling, cysts and placental infarctions, a high frequency of diffuse changes in placental tissue, and hyperechogenic inclusions in the amniotic fluid. An increase in the resistance index in the uterine arteries of pregnant women, especially those with subclinical hypothyroidism, is noteworthy. With increasing gestational age, the peripheral resistance of the placental microvasculature increases due to involutional-dystrophic changes and circulatory disorders, which allows us to develop criteria for the prognosis and diagnosis of placental dysfunction, and to prevent perinatal disorders in pregnant women with thyroid disease. |
| format | Article |
| id | doaj-art-ff44c6b1feb44779a702372168d538f5 |
| institution | Kabale University |
| issn | 2224-0721 2307-1427 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Zaslavsky O.Yu. |
| record_format | Article |
| series | Mìžnarodnij Endokrinologìčnij Žurnal |
| spelling | doaj-art-ff44c6b1feb44779a702372168d538f52024-11-10T19:05:51ZengZaslavsky O.Yu.Mìžnarodnij Endokrinologìčnij Žurnal2224-07212307-14272024-06-0120432332710.22141/2224-0721.20.4.2024.14121410The association of maternal thyroid function with placental hemodynamics during pregnancyO.S. Paienok0https://orcid.org/0000-0002-8517-7424R.G. Protsiuk1https://orcid.org/0000-0002-8434-8949A.V. Paienok2https://orcid.org/0000-0003-0531-751XB.V. Zadorozhna3https://orcid.org/0000-0001-6717-5233B.R. Hrytsyshyn4https://orcid.org/0009-0007-9819-7866S.V. Ihnatovych5Львівський національний медичний університет імені Данила Галицького, м. Львів, УкраїнаНаціональний медичний університет імені О.О. Богомольця, м. Київ, УкраїнаЛьвівський національний медичний університет імені Данила Галицького, м. Львів, УкраїнаЛьвівський національний медичний університет імені Данила Галицького, м. Львів, УкраїнаЛьвівська обласна клінічна лікарня, м. Львів, УкраїнаЛьвівська обласна клінічна лікарня, м. Львів, УкраїнаWe examined 164 pregnant women who were divided into three groups. Group I included 76 pregnant women (46.4 %) with euthyroid goiter of I–II degree. Group II consisted of 63 pregnant women (38.4 %) with subclinical hypothyroidism and diffuse thyroid goiter of I–II degree. Group III was the controls and consisted of 25 (15.2 %) pregnant women without thyroid pathology. The placenta was studied with the characteristics of ultrasound placentography, placental maturation disorders, the area and localization were determined, and pathological changes in the placental tissue were detected. Changes in the systolic-diastolic ratio in the uterine arteries and umbilical cord arteries were assessed, the resistance index in the uterine arteries, the pulsatile index in the fetal aorta and middle cerebral artery were determined using the method of color Doppler mapping of blood flow in the mother-placenta-fetus system. Study of the echographic picture of structural changes in the placenta revealed a significant impairment of its maturation, especially in the group with euthyroidism. Ultrasound screening revealed that in every second pregnant woman with thyroid disease, the condition of the placenta did not correspond to the gestational age, there were swelling, cysts and placental infarctions, a high frequency of diffuse changes in placental tissue, and hyperechogenic inclusions in the amniotic fluid. An increase in the resistance index in the uterine arteries of pregnant women, especially those with subclinical hypothyroidism, is noteworthy. With increasing gestational age, the peripheral resistance of the placental microvasculature increases due to involutional-dystrophic changes and circulatory disorders, which allows us to develop criteria for the prognosis and diagnosis of placental dysfunction, and to prevent perinatal disorders in pregnant women with thyroid disease.https://iej.zaslavsky.com.ua/index.php/journal/article/view/1412hypothyroidismthyroid glandpregnancyplacental dysfunctiondopplerometryplacentography |
| spellingShingle | O.S. Paienok R.G. Protsiuk A.V. Paienok B.V. Zadorozhna B.R. Hrytsyshyn S.V. Ihnatovych The association of maternal thyroid function with placental hemodynamics during pregnancy Mìžnarodnij Endokrinologìčnij Žurnal hypothyroidism thyroid gland pregnancy placental dysfunction dopplerometry placentography |
| title | The association of maternal thyroid function with placental hemodynamics during pregnancy |
| title_full | The association of maternal thyroid function with placental hemodynamics during pregnancy |
| title_fullStr | The association of maternal thyroid function with placental hemodynamics during pregnancy |
| title_full_unstemmed | The association of maternal thyroid function with placental hemodynamics during pregnancy |
| title_short | The association of maternal thyroid function with placental hemodynamics during pregnancy |
| title_sort | association of maternal thyroid function with placental hemodynamics during pregnancy |
| topic | hypothyroidism thyroid gland pregnancy placental dysfunction dopplerometry placentography |
| url | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1412 |
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