Multimodal MRI reveals impaired glymphatic function with choroid plexus enlargement and cerebrospinal fluid expansion in alzheimer’s disease

Multimodal MRI reveals impaired glymphatic function with choroid plexus enlargement and cerebrospinal fluid expansion in alzheimer’s disease

Abstract There is increasing evidence that cerebrospinal fluid (CSF) circulation plays a key role in the pathophysiology of Alzheimer’s disease (AD), although the underlying mechanisms remain poorly understood. This study evaluated CSF circulation in patients with AD using magnetic resonance imaging...

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Bibliographic Details
Main Authors: Weiqi Lin, Huijuan Chen, Zhanrong Zhang, Yiying Zhang, Xingqun Wang, Yihao Guo, Haodong Qin, Tao Liu, Feng Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Cerebrospinal fluid circulation
DTI-ALPS
Choroid plexus volume
Cerebrospinal fluid volume
Alzheimer’s disease
Online Access:https://doi.org/10.1038/s41598-025-15923-8
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