Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise
ObjectiveTo explore the impact of type 2 diabetes mellitus (T2DM) on exercise tolerance and fat oxidation capacity in patients with heart failure (HF).MethodsWe retrospectively analyzed 108 Chinese patients with HF who were divided into a diabetic group (T2DM group, n = 47) and a non-diabetic group...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1485755/full |
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| author | Huiying Zhu Huiying Zhu Jianchao Pan Jianxuan Wen Jianxuan Wen Xiaojing Dang Xiaojing Dang Xiankun Chen Xiankun Chen Yunxiang Fan Yunxiang Fan Weihui Lu Weihui Lu Wei Jiang Wei Jiang |
| author_facet | Huiying Zhu Huiying Zhu Jianchao Pan Jianxuan Wen Jianxuan Wen Xiaojing Dang Xiaojing Dang Xiankun Chen Xiankun Chen Yunxiang Fan Yunxiang Fan Weihui Lu Weihui Lu Wei Jiang Wei Jiang |
| author_sort | Huiying Zhu |
| collection | DOAJ |
| description | ObjectiveTo explore the impact of type 2 diabetes mellitus (T2DM) on exercise tolerance and fat oxidation capacity in patients with heart failure (HF).MethodsWe retrospectively analyzed 108 Chinese patients with HF who were divided into a diabetic group (T2DM group, n = 47) and a non-diabetic group (non-T2DM group, n = 61). All subjects completed cardiopulmonary exercise testing (CPX). We determined their fat oxidation (FATox) by indirect calorimetry.ResultsIn the HF patients, the peak oxygen uptake (VO2) value was 14.76 ± 3.27 ml/kg/min in the T2DM group and 17.76 ± 4.64 ml/kg/min in the non-T2DM group. After adjusting for age, sex, body mass index (BMI), log N-terminal pro-B type natriuretic peptide (log NT-proBNP), left ventricular ejection fraction (LVEF), hemoglobin, renal function, coronary heart disease and hypertension, the peak VO2 was lower in the T2DM group compared to the non-T2DM group with a mean difference (MD) of −2.0 ml/kg/min [95% confidence interval (CI), −3.18 to −0.82, P < 0.01]. The VO2 at anaerobic threshold (AT VO2) was also lower in the T2DM group than in the non-T2DM group, with a MD of −1.11 ml/kg/min (95% CI −2.04 to −0.18, P < 0.05). Regarding the fat oxidation capacity during CPX, the T2DM group's maximal fat oxidation (MFO) was lower than that of the non-T2DM group (0.143 ± 0.055 vs. 0.169 ± 0.061 g/min, P < 0.05). In addition, the T2DM group had lower FATox at exercise intensity levels of 40% (P < 0.05) and 50% (P < 0.05) of peak VO2, compared to the non-T2DM group.ConclusionsT2DM is associated with a decrease in exercise tolerance and fat oxidation capacity in patients with heart failure. Thus, it could be useful to develop exercises of appropriate intensity to optimize physical and metabolic health. |
| format | Article |
| id | doaj-art-ff3e0e5797aa4effad3846e5ee8fcff5 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-ff3e0e5797aa4effad3846e5ee8fcff52025-02-10T06:48:35ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-02-011210.3389/fcvm.2025.14857551485755Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exerciseHuiying Zhu0Huiying Zhu1Jianchao Pan2Jianxuan Wen3Jianxuan Wen4Xiaojing Dang5Xiaojing Dang6Xiankun Chen7Xiankun Chen8Yunxiang Fan9Yunxiang Fan10Weihui Lu11Weihui Lu12Wei Jiang13Wei Jiang14The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaThe Second Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, ChinaThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Endocrinology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaKey Unit of Methodology in Clinical Research, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaHeart Failure Center/Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaHeart Failure Center/Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, ChinaObjectiveTo explore the impact of type 2 diabetes mellitus (T2DM) on exercise tolerance and fat oxidation capacity in patients with heart failure (HF).MethodsWe retrospectively analyzed 108 Chinese patients with HF who were divided into a diabetic group (T2DM group, n = 47) and a non-diabetic group (non-T2DM group, n = 61). All subjects completed cardiopulmonary exercise testing (CPX). We determined their fat oxidation (FATox) by indirect calorimetry.ResultsIn the HF patients, the peak oxygen uptake (VO2) value was 14.76 ± 3.27 ml/kg/min in the T2DM group and 17.76 ± 4.64 ml/kg/min in the non-T2DM group. After adjusting for age, sex, body mass index (BMI), log N-terminal pro-B type natriuretic peptide (log NT-proBNP), left ventricular ejection fraction (LVEF), hemoglobin, renal function, coronary heart disease and hypertension, the peak VO2 was lower in the T2DM group compared to the non-T2DM group with a mean difference (MD) of −2.0 ml/kg/min [95% confidence interval (CI), −3.18 to −0.82, P < 0.01]. The VO2 at anaerobic threshold (AT VO2) was also lower in the T2DM group than in the non-T2DM group, with a MD of −1.11 ml/kg/min (95% CI −2.04 to −0.18, P < 0.05). Regarding the fat oxidation capacity during CPX, the T2DM group's maximal fat oxidation (MFO) was lower than that of the non-T2DM group (0.143 ± 0.055 vs. 0.169 ± 0.061 g/min, P < 0.05). In addition, the T2DM group had lower FATox at exercise intensity levels of 40% (P < 0.05) and 50% (P < 0.05) of peak VO2, compared to the non-T2DM group.ConclusionsT2DM is associated with a decrease in exercise tolerance and fat oxidation capacity in patients with heart failure. Thus, it could be useful to develop exercises of appropriate intensity to optimize physical and metabolic health.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1485755/fullheart failuretype 2 diabetes mellitusexercise tolerancemaximal fat oxidationfat oxidation |
| spellingShingle | Huiying Zhu Huiying Zhu Jianchao Pan Jianxuan Wen Jianxuan Wen Xiaojing Dang Xiaojing Dang Xiankun Chen Xiankun Chen Yunxiang Fan Yunxiang Fan Weihui Lu Weihui Lu Wei Jiang Wei Jiang Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise Frontiers in Cardiovascular Medicine heart failure type 2 diabetes mellitus exercise tolerance maximal fat oxidation fat oxidation |
| title | Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise |
| title_full | Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise |
| title_fullStr | Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise |
| title_full_unstemmed | Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise |
| title_short | Type 2 diabetes mellitus’ impact on heart failure patients’ exercise tolerance: a focus on maximal fat oxidation during exercise |
| title_sort | type 2 diabetes mellitus impact on heart failure patients exercise tolerance a focus on maximal fat oxidation during exercise |
| topic | heart failure type 2 diabetes mellitus exercise tolerance maximal fat oxidation fat oxidation |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1485755/full |
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