A review of testicular histopathology in nonobstructive azoospermia
One major challenge in male factor infertility is nonobstructive azoospermia (NOA), which is characterized by spermatozoa-deficient semen without physical duct blockage. This review offers a thorough overview of the histopathology of the testes in NOA cases, clarifying its complex etiology and empha...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-05-01
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| Series: | Asian Journal of Andrology |
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| Online Access: | https://journals.lww.com/10.4103/aja202454 |
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| author | Taymour Mostafa Kadir Bocu Vineet Malhotra |
| author_facet | Taymour Mostafa Kadir Bocu Vineet Malhotra |
| author_sort | Taymour Mostafa |
| collection | DOAJ |
| description | One major challenge in male factor infertility is nonobstructive azoospermia (NOA), which is characterized by spermatozoa-deficient semen without physical duct blockage. This review offers a thorough overview of the histopathology of the testes in NOA cases, clarifying its complex etiology and emphasizing the possible value of histopathology inspection for both diagnosis and treatment. Variable histopathological findings have been linked to NOA, such as tubular hyalinization, Sertoli cell-only syndrome, hypospermatogenesis, and germ cell arrest. Understanding the pathophysiology and forecasting the effectiveness of treatment are further enhanced by both morphometric and ultrastructural analyses. The potential significance of testicular biopsy in forecasting reproductive outcomes is assessed, especially concerning assisted reproductive technologies like intracytoplasmic sperm injection (ICSI). Besides, testicular microlithiasis, serum hormone profiles, and testicular size are investigated concerning NOA histopathology. It is concluded that understanding the histopathological patterns in NOA is crucial for its accurate diagnosis and appropriate management. Further research is still warranted to improve understanding of the complex pathophysiology underlying NOA. |
| format | Article |
| id | doaj-art-ff2f00d5beec49cf8569c68a33cd9339 |
| institution | DOAJ |
| issn | 1008-682X 1745-7262 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Journal of Andrology |
| spelling | doaj-art-ff2f00d5beec49cf8569c68a33cd93392025-08-20T03:07:40ZengWolters Kluwer Medknow PublicationsAsian Journal of Andrology1008-682X1745-72622025-05-0127337037410.4103/aja202454A review of testicular histopathology in nonobstructive azoospermiaTaymour MostafaKadir BocuVineet MalhotraOne major challenge in male factor infertility is nonobstructive azoospermia (NOA), which is characterized by spermatozoa-deficient semen without physical duct blockage. This review offers a thorough overview of the histopathology of the testes in NOA cases, clarifying its complex etiology and emphasizing the possible value of histopathology inspection for both diagnosis and treatment. Variable histopathological findings have been linked to NOA, such as tubular hyalinization, Sertoli cell-only syndrome, hypospermatogenesis, and germ cell arrest. Understanding the pathophysiology and forecasting the effectiveness of treatment are further enhanced by both morphometric and ultrastructural analyses. The potential significance of testicular biopsy in forecasting reproductive outcomes is assessed, especially concerning assisted reproductive technologies like intracytoplasmic sperm injection (ICSI). Besides, testicular microlithiasis, serum hormone profiles, and testicular size are investigated concerning NOA histopathology. It is concluded that understanding the histopathological patterns in NOA is crucial for its accurate diagnosis and appropriate management. Further research is still warranted to improve understanding of the complex pathophysiology underlying NOA.https://journals.lww.com/10.4103/aja202454azoospermiahistopathologymale infertilitynonobstructive azoospermiasemen |
| spellingShingle | Taymour Mostafa Kadir Bocu Vineet Malhotra A review of testicular histopathology in nonobstructive azoospermia Asian Journal of Andrology azoospermia histopathology male infertility nonobstructive azoospermia semen |
| title | A review of testicular histopathology in nonobstructive azoospermia |
| title_full | A review of testicular histopathology in nonobstructive azoospermia |
| title_fullStr | A review of testicular histopathology in nonobstructive azoospermia |
| title_full_unstemmed | A review of testicular histopathology in nonobstructive azoospermia |
| title_short | A review of testicular histopathology in nonobstructive azoospermia |
| title_sort | review of testicular histopathology in nonobstructive azoospermia |
| topic | azoospermia histopathology male infertility nonobstructive azoospermia semen |
| url | https://journals.lww.com/10.4103/aja202454 |
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