Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthma
Background: Eosinophils are crucial in allergic inflammation, and their correlation with asthma severity has made them a focal point in predicting treatment outcomes. Blood eosinophil count is a commonly utilized marker. However, its limitations have prompted alternative biomarker exploration, such...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | World Allergy Organization Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455124001224 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841526318465810432 |
|---|---|
| author | Yu Ri Kang, MD Hyunkyoung Kim, MS, MPH Chae Eun Lee, BS Jae-Woo Jung, MD, PhD Ji-Yong Moon, MD, PhD So Young Park, MD, MS Sae-Hoon Kim, MD, PhD Min-Suk Yang, MD, PhD Byung Keun Kim, MD, PhD Jae-Woo Kwon, MD, PhD Hye-Kyung Park, MD, PhD Young-Hee Nam, MD, PhD Young-Joo Cho, MD, PhD Taehoon Lee, MD, PhD Ian M. Adcock, MD, PhD Pank Bhavsar, MD, PhD Kian Fan Chung, MD, PhD Tae-Bum Kim, MD, PhD |
| author_facet | Yu Ri Kang, MD Hyunkyoung Kim, MS, MPH Chae Eun Lee, BS Jae-Woo Jung, MD, PhD Ji-Yong Moon, MD, PhD So Young Park, MD, MS Sae-Hoon Kim, MD, PhD Min-Suk Yang, MD, PhD Byung Keun Kim, MD, PhD Jae-Woo Kwon, MD, PhD Hye-Kyung Park, MD, PhD Young-Hee Nam, MD, PhD Young-Joo Cho, MD, PhD Taehoon Lee, MD, PhD Ian M. Adcock, MD, PhD Pank Bhavsar, MD, PhD Kian Fan Chung, MD, PhD Tae-Bum Kim, MD, PhD |
| author_sort | Yu Ri Kang, MD |
| collection | DOAJ |
| description | Background: Eosinophils are crucial in allergic inflammation, and their correlation with asthma severity has made them a focal point in predicting treatment outcomes. Blood eosinophil count is a commonly utilized marker. However, its limitations have prompted alternative biomarker exploration, such as eosinophil-derived neurotoxin (EDN). Objective: This research was conducted over 24 weeks on 56 patients with severe asthma treated with mepolizumab, reslizumab, and dupilumab. We aimed to evaluate the clinical significance of blood eosinophil count and their potential, including those of blood EDN levels and urine EDN values as biomarkers for predicting treatment response. Methods: The analysis encompassed examining correlations between biomarkers and clinical features, including exacerbation rates and lung function, through ELISA assays and subsequent statistical analyses. The study protocol is registered at ClinicalTrials.gov (NCT05164939). Results: The findings underscore strong correlations between serum EDN levels, blood eosinophil counts, and treatment responses, with EDN demonstrating comparable predictive capabilities to blood eosinophil counts to determine treatment responses. Different biologics exhibited varying efficacy regarding baseline eosinophil counts and EDN levels. Conclusions: Blood eosinophil counts and EDN levels show potential as predictive markers for treatment responses in patients with severe asthma undergoing biologic therapies. However, further comprehensive studies are warranted to enhance the reliability and applicability of EDN as an effective asthma treatment biomarker. |
| format | Article |
| id | doaj-art-ff2d681417494ab083405cee9f2ee90b |
| institution | Kabale University |
| issn | 1939-4551 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj-art-ff2d681417494ab083405cee9f2ee90b2025-01-17T04:49:14ZengElsevierWorld Allergy Organization Journal1939-45512025-01-01181100990Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthmaYu Ri Kang, MD0Hyunkyoung Kim, MS, MPH1Chae Eun Lee, BS2Jae-Woo Jung, MD, PhD3Ji-Yong Moon, MD, PhD4So Young Park, MD, MS5Sae-Hoon Kim, MD, PhD6Min-Suk Yang, MD, PhD7Byung Keun Kim, MD, PhD8Jae-Woo Kwon, MD, PhD9Hye-Kyung Park, MD, PhD10Young-Hee Nam, MD, PhD11Young-Joo Cho, MD, PhD12Taehoon Lee, MD, PhD13Ian M. Adcock, MD, PhD14Pank Bhavsar, MD, PhD15Kian Fan Chung, MD, PhD16Tae-Bum Kim, MD, PhD17Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, South KoreaDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaDepartment of Internal Medicine, Chung-Ang University College of Medicine, Seoul, South KoreaDepartment of Internal Medicine, Hanyang University College of Medicine, Seoul, South KoreaDepartment of Internal Medicine, Eulji University School of Medicine, Seoul, South KoreaDepartment of Internal Medicine, Division of Allergy and Clinical Immunology, Seoul National University Bundang Hospital, Seongnam, South KoreaDepartment of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South KoreaDepartment of Internal Medicine, Korea University Medical Center Anam Hospital, Seoul, South KoreaDepartment of Allergy and Clinical Immunology, Kangwon National University School of Medicine, Chuncheon, South KoreaDepartment of Internal Medicine, Pusan National University Hospital, Pusan National University College of Medicine, Busan, South KoreaDepartment of Internal Medicine, Dong-A University College of Medicine, Busan, South KoreaDepartment of Allergy and Clinical Immunology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, South KoreaDepartment of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South KoreaNational Heart and Lung Institute, London, UKNational Heart and Lung Institute, London, UKNational Heart and Lung Institute, London, UKDepartment of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; Corresponding author. Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.Background: Eosinophils are crucial in allergic inflammation, and their correlation with asthma severity has made them a focal point in predicting treatment outcomes. Blood eosinophil count is a commonly utilized marker. However, its limitations have prompted alternative biomarker exploration, such as eosinophil-derived neurotoxin (EDN). Objective: This research was conducted over 24 weeks on 56 patients with severe asthma treated with mepolizumab, reslizumab, and dupilumab. We aimed to evaluate the clinical significance of blood eosinophil count and their potential, including those of blood EDN levels and urine EDN values as biomarkers for predicting treatment response. Methods: The analysis encompassed examining correlations between biomarkers and clinical features, including exacerbation rates and lung function, through ELISA assays and subsequent statistical analyses. The study protocol is registered at ClinicalTrials.gov (NCT05164939). Results: The findings underscore strong correlations between serum EDN levels, blood eosinophil counts, and treatment responses, with EDN demonstrating comparable predictive capabilities to blood eosinophil counts to determine treatment responses. Different biologics exhibited varying efficacy regarding baseline eosinophil counts and EDN levels. Conclusions: Blood eosinophil counts and EDN levels show potential as predictive markers for treatment responses in patients with severe asthma undergoing biologic therapies. However, further comprehensive studies are warranted to enhance the reliability and applicability of EDN as an effective asthma treatment biomarker.http://www.sciencedirect.com/science/article/pii/S1939455124001224EosinophilsAllergic inflammationAsthmaEosinophil-derived neurotoxinBlood eosinophil countsBiologic therapies |
| spellingShingle | Yu Ri Kang, MD Hyunkyoung Kim, MS, MPH Chae Eun Lee, BS Jae-Woo Jung, MD, PhD Ji-Yong Moon, MD, PhD So Young Park, MD, MS Sae-Hoon Kim, MD, PhD Min-Suk Yang, MD, PhD Byung Keun Kim, MD, PhD Jae-Woo Kwon, MD, PhD Hye-Kyung Park, MD, PhD Young-Hee Nam, MD, PhD Young-Joo Cho, MD, PhD Taehoon Lee, MD, PhD Ian M. Adcock, MD, PhD Pank Bhavsar, MD, PhD Kian Fan Chung, MD, PhD Tae-Bum Kim, MD, PhD Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthma World Allergy Organization Journal Eosinophils Allergic inflammation Asthma Eosinophil-derived neurotoxin Blood eosinophil counts Biologic therapies |
| title | Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthma |
| title_full | Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthma |
| title_fullStr | Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthma |
| title_full_unstemmed | Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthma |
| title_short | Serum and urine eosinophil-derived neurotoxin (EDN) levels predict biologic response in severe asthma |
| title_sort | serum and urine eosinophil derived neurotoxin edn levels predict biologic response in severe asthma |
| topic | Eosinophils Allergic inflammation Asthma Eosinophil-derived neurotoxin Blood eosinophil counts Biologic therapies |
| url | http://www.sciencedirect.com/science/article/pii/S1939455124001224 |
| work_keys_str_mv | AT yurikangmd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT hyunkyoungkimmsmph serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT chaeeunleebs serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT jaewoojungmdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT jiyongmoonmdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT soyoungparkmdms serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT saehoonkimmdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT minsukyangmdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT byungkeunkimmdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT jaewookwonmdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT hyekyungparkmdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT youngheenammdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT youngjoochomdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT taehoonleemdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT ianmadcockmdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT pankbhavsarmdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT kianfanchungmdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma AT taebumkimmdphd serumandurineeosinophilderivedneurotoxinednlevelspredictbiologicresponseinsevereasthma |