Differences between multi-triggered and single-triggered food anaphylaxis in children: a real life study
Background. Food-induced anaphylaxis (FIA) is a severe form of food allergy, and literature data about multi-triggered FIA is scarce. This study aimed to evaluate the differences between multi-triggered and single-triggered food anaphylaxis in children. Methods. The study included pediatric patie...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2025-07-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/5788 |
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| author | Şule Büyük Yaytokgil İlknur Külhaş Çelik Zeynep Şengül Emeksiz Betül Karaatmaca Tayfur Giniş Selma Alim Aydın Müge Toyran Emine Dibek Mısırlıoğlu Ersoy Civelek |
| author_facet | Şule Büyük Yaytokgil İlknur Külhaş Çelik Zeynep Şengül Emeksiz Betül Karaatmaca Tayfur Giniş Selma Alim Aydın Müge Toyran Emine Dibek Mısırlıoğlu Ersoy Civelek |
| author_sort | Şule Büyük Yaytokgil |
| collection | DOAJ |
| description |
Background. Food-induced anaphylaxis (FIA) is a severe form of food allergy, and literature data about multi-triggered FIA is scarce. This study aimed to evaluate the differences between multi-triggered and single-triggered food anaphylaxis in children.
Methods. The study included pediatric patients (age 100 IU/mL was identified as a predictive factor for multi-triggered FIA (Odds ratio (95% CI): 2.46 (1.40-4.30), p=0.001).
Conclusions. FIA with multiple trigger foods was detected in approximately a quarter of the children with FIA. Multi-triggered FIA was associated with higher rates of atopic disease, asthma, eosinophilia, and increased total IgE levels. A total IgE level higher than 100 IU/mL was a risk factor for multi-triggered FIA. This suggests that high IgE levels may be a warning sign for clinicians to be vigilant for multiple food triggers in the screening and follow-up of FIA patients.
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| format | Article |
| id | doaj-art-ff2b689f18e8448fb6d54892f20aaecd |
| institution | Kabale University |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-ff2b689f18e8448fb6d54892f20aaecd2025-08-20T03:35:46ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212025-07-0167310.24953/turkjpediatr.2025.5788Differences between multi-triggered and single-triggered food anaphylaxis in children: a real life studyŞule Büyük Yaytokgil0https://orcid.org/0000-0002-9393-7497İlknur Külhaş Çelik1https://orcid.org/0000-0003-3812-9654Zeynep Şengül Emeksiz2https://orcid.org/0000-0001-7648-0352Betül Karaatmaca3https://orcid.org/0000-0002-8383-6350Tayfur Giniş4https://orcid.org/0000-0003-1939-3951Selma Alim Aydın5https://orcid.org/0000-0002-0102-0711Müge Toyran6https://orcid.org/0000-0002-2490-0551Emine Dibek Mısırlıoğlu7https://orcid.org/0000-0002-3241-2005Ersoy Civelek8https://orcid.org/0000-0002-1780-4801Department of Pediatric Allergy/Immunology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Türkiye; Department of Pediatric Allergy/Immunology, Ankara Training and Research Hospital, Ankara, TürkiyeDepartment of Pediatric Allergy/Immunology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Türkiye; Department of Pediatric Allergy/Immunology, Faculty of Medicine, Selçuk University, Konya, TürkiyeDepartment of Pediatric Allergy/Immunology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, TürkiyeDepartment of Pediatric Allergy/Immunology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, TürkiyeDepartment of Pediatric Allergy/Immunology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, TürkiyeDepartment of Pediatric Allergy/Immunology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Türkiye; Department of Pediatric Allergy/Immunology, Sivas City Hospital, Sivas, TürkiyeDepartment of Pediatric Allergy/Immunology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Türkiye; Department of Pediatric Allergy/Immunology, Bayındır Hospital, Ankara, TürkiyeDepartment of Pediatric Allergy/Immunology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, TürkiyeDepartment of Pediatric Allergy/Immunology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Türkiye; Department of Pediatric Allergy/Immunology, Memorial Hospital, Ankara, Türkiye Background. Food-induced anaphylaxis (FIA) is a severe form of food allergy, and literature data about multi-triggered FIA is scarce. This study aimed to evaluate the differences between multi-triggered and single-triggered food anaphylaxis in children. Methods. The study included pediatric patients (age 100 IU/mL was identified as a predictive factor for multi-triggered FIA (Odds ratio (95% CI): 2.46 (1.40-4.30), p=0.001). Conclusions. FIA with multiple trigger foods was detected in approximately a quarter of the children with FIA. Multi-triggered FIA was associated with higher rates of atopic disease, asthma, eosinophilia, and increased total IgE levels. A total IgE level higher than 100 IU/mL was a risk factor for multi-triggered FIA. This suggests that high IgE levels may be a warning sign for clinicians to be vigilant for multiple food triggers in the screening and follow-up of FIA patients. https://turkjpediatr.org/article/view/5788anaphylaxisfood induced anaphylaxismultiple triggeredsingle triggeredtotal IgE |
| spellingShingle | Şule Büyük Yaytokgil İlknur Külhaş Çelik Zeynep Şengül Emeksiz Betül Karaatmaca Tayfur Giniş Selma Alim Aydın Müge Toyran Emine Dibek Mısırlıoğlu Ersoy Civelek Differences between multi-triggered and single-triggered food anaphylaxis in children: a real life study The Turkish Journal of Pediatrics anaphylaxis food induced anaphylaxis multiple triggered single triggered total IgE |
| title | Differences between multi-triggered and single-triggered food anaphylaxis in children: a real life study |
| title_full | Differences between multi-triggered and single-triggered food anaphylaxis in children: a real life study |
| title_fullStr | Differences between multi-triggered and single-triggered food anaphylaxis in children: a real life study |
| title_full_unstemmed | Differences between multi-triggered and single-triggered food anaphylaxis in children: a real life study |
| title_short | Differences between multi-triggered and single-triggered food anaphylaxis in children: a real life study |
| title_sort | differences between multi triggered and single triggered food anaphylaxis in children a real life study |
| topic | anaphylaxis food induced anaphylaxis multiple triggered single triggered total IgE |
| url | https://turkjpediatr.org/article/view/5788 |
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