Antiviral Activity of Rambutan Peel Polyphenols Obtained Using Green Extraction Technology and Solvents
Rambutan peel is a great source of bioactive compounds, the same that, over the years, has been extracted using conventional technologies which have been proven to be harmful to the environment and potentially toxic to human beings. This study aimed to extract the same compounds using a hybridizatio...
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MDPI AG
2025-04-01
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| Series: | Sustainable Chemistry |
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| author | Christian Hernández-Hernández Luis E. Estrada-Gil Sonia A. Lozano-Sepúlveda Ana M. Rivas-Estilla Mayela Govea-Salas Jesús Morlett-Chávez Cristóbal N. Aguilar Juan A. Ascacio-Valdés |
| author_facet | Christian Hernández-Hernández Luis E. Estrada-Gil Sonia A. Lozano-Sepúlveda Ana M. Rivas-Estilla Mayela Govea-Salas Jesús Morlett-Chávez Cristóbal N. Aguilar Juan A. Ascacio-Valdés |
| author_sort | Christian Hernández-Hernández |
| collection | DOAJ |
| description | Rambutan peel is a great source of bioactive compounds, the same that, over the years, has been extracted using conventional technologies which have been proven to be harmful to the environment and potentially toxic to human beings. This study aimed to extract the same compounds using a hybridization of ultrasound/microwave extraction. The results were promising, as a total of 378.48 ± 9.19 mg/g of polyphenols were recovered from this procedure, and the most important molecules (geraniin, corilagin, and ellagic acid) were identified, giving this much more relevance. Furthermore, treatment with rambutan peel extract recovered with green technologies significantly reduced cell viability in HCV-infected liver cells. Notably, higher concentrations (4000 and 5000 ppm) led to more pronounced cell death in huh7 cells. The treatment also led to a significant reduction in viral protein and RNA expression in HCV-infected cells. These findings suggest that rambutan peel extract obtained from the combination of ultrasound and microwave extraction, particularly the ellagitannins present, have potential antiviral properties. Further research is needed to explore its mechanism of action and its potential as a therapeutic agent for Hepatitis C. |
| format | Article |
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| institution | Kabale University |
| issn | 2673-4079 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sustainable Chemistry |
| spelling | doaj-art-ff2a9acd98f54fa2969ecb3a5594e4092025-08-20T03:27:43ZengMDPI AGSustainable Chemistry2673-40792025-04-01621410.3390/suschem6020014Antiviral Activity of Rambutan Peel Polyphenols Obtained Using Green Extraction Technology and SolventsChristian Hernández-Hernández0Luis E. Estrada-Gil1Sonia A. Lozano-Sepúlveda2Ana M. Rivas-Estilla3Mayela Govea-Salas4Jesús Morlett-Chávez5Cristóbal N. Aguilar6Juan A. Ascacio-Valdés7Bioprocesses & Bioproducts Research Group, Food Research Department, School of Chemistry, Autonomous University of Coahuila, Saltillo 25280, Coahuila, MexicoBioprocesses & Bioproducts Research Group, Food Research Department, School of Chemistry, Autonomous University of Coahuila, Saltillo 25280, Coahuila, MexicoCenter for Innovation and Research in Medical Virology, School of Medicine, Autonomous University of Nuevo Leon, Monterrey 66450, Nuevo Leon, MexicoBiochemistry and Molecular Medicine Department, School of Medicine, Autonomous University of Nuevo Leon, Monterrey 66450, Nuevo Leon, MexicoLaboratory of Nanobiosciences, School of Chemistry, Autonomous University of Coahuila, Saltillo 25280, Coahuila, MexicoLaboratory of Molecular Biology, Health Research Department, School of Medicine, Autonomous University of Coahuila, Saltillo 25280, Coahuila, MexicoBioprocesses & Bioproducts Research Group, Food Research Department, School of Chemistry, Autonomous University of Coahuila, Saltillo 25280, Coahuila, MexicoBioprocesses & Bioproducts Research Group, Food Research Department, School of Chemistry, Autonomous University of Coahuila, Saltillo 25280, Coahuila, MexicoRambutan peel is a great source of bioactive compounds, the same that, over the years, has been extracted using conventional technologies which have been proven to be harmful to the environment and potentially toxic to human beings. This study aimed to extract the same compounds using a hybridization of ultrasound/microwave extraction. The results were promising, as a total of 378.48 ± 9.19 mg/g of polyphenols were recovered from this procedure, and the most important molecules (geraniin, corilagin, and ellagic acid) were identified, giving this much more relevance. Furthermore, treatment with rambutan peel extract recovered with green technologies significantly reduced cell viability in HCV-infected liver cells. Notably, higher concentrations (4000 and 5000 ppm) led to more pronounced cell death in huh7 cells. The treatment also led to a significant reduction in viral protein and RNA expression in HCV-infected cells. These findings suggest that rambutan peel extract obtained from the combination of ultrasound and microwave extraction, particularly the ellagitannins present, have potential antiviral properties. Further research is needed to explore its mechanism of action and its potential as a therapeutic agent for Hepatitis C.https://www.mdpi.com/2673-4079/6/2/14ellagitanninsmicrowave-/ultrasound-assisted extractionhybrid technologyantiproliferative |
| spellingShingle | Christian Hernández-Hernández Luis E. Estrada-Gil Sonia A. Lozano-Sepúlveda Ana M. Rivas-Estilla Mayela Govea-Salas Jesús Morlett-Chávez Cristóbal N. Aguilar Juan A. Ascacio-Valdés Antiviral Activity of Rambutan Peel Polyphenols Obtained Using Green Extraction Technology and Solvents Sustainable Chemistry ellagitannins microwave-/ultrasound-assisted extraction hybrid technology antiproliferative |
| title | Antiviral Activity of Rambutan Peel Polyphenols Obtained Using Green Extraction Technology and Solvents |
| title_full | Antiviral Activity of Rambutan Peel Polyphenols Obtained Using Green Extraction Technology and Solvents |
| title_fullStr | Antiviral Activity of Rambutan Peel Polyphenols Obtained Using Green Extraction Technology and Solvents |
| title_full_unstemmed | Antiviral Activity of Rambutan Peel Polyphenols Obtained Using Green Extraction Technology and Solvents |
| title_short | Antiviral Activity of Rambutan Peel Polyphenols Obtained Using Green Extraction Technology and Solvents |
| title_sort | antiviral activity of rambutan peel polyphenols obtained using green extraction technology and solvents |
| topic | ellagitannins microwave-/ultrasound-assisted extraction hybrid technology antiproliferative |
| url | https://www.mdpi.com/2673-4079/6/2/14 |
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