Interactions of human milk oligosaccharides with the immune system
Human milk oligosaccharides (HMOs) are abundant, diverse and complex sugars present in human breast milk. HMOs are well-characterized barriers to microbial infection and by modulating the human microbiome they are also thought to be nutritionally beneficial to the infant. The structural variety of o...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1523829/full |
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| author | Alanna S. Slater Alanna S. Slater Rita M. Hickey Gavin P. Davey |
| author_facet | Alanna S. Slater Alanna S. Slater Rita M. Hickey Gavin P. Davey |
| author_sort | Alanna S. Slater |
| collection | DOAJ |
| description | Human milk oligosaccharides (HMOs) are abundant, diverse and complex sugars present in human breast milk. HMOs are well-characterized barriers to microbial infection and by modulating the human microbiome they are also thought to be nutritionally beneficial to the infant. The structural variety of over 200 HMOs, including neutral, fucosylated and sialylated forms, allows them to interact with the immune system in various ways. Clinically, HMOs impact allergic diseases, reducing autoimmune and inflammatory responses, and offer beneficial support to the preterm infant immune health. This review examines the HMO composition and associated immunomodulatory effects, including interactions with immune cell receptors and gut-associated immune responses. These immunomodulatory properties highlight the potential for HMO use in early stage immune development and for use as novel immunotherapeutics. HMO research is rapidly evolving and promises innovative treatments for immune-related conditions and improved health outcomes. |
| format | Article |
| id | doaj-art-ff286bdfe8b84a07885e15bdd6dfd494 |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-ff286bdfe8b84a07885e15bdd6dfd4942025-01-14T06:10:22ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.15238291523829Interactions of human milk oligosaccharides with the immune systemAlanna S. Slater0Alanna S. Slater1Rita M. Hickey2Gavin P. Davey3Teagasc Food Research Centre, Moorepark, Fermoy, IrelandSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, IrelandTeagasc Food Research Centre, Moorepark, Fermoy, IrelandSchool of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, IrelandHuman milk oligosaccharides (HMOs) are abundant, diverse and complex sugars present in human breast milk. HMOs are well-characterized barriers to microbial infection and by modulating the human microbiome they are also thought to be nutritionally beneficial to the infant. The structural variety of over 200 HMOs, including neutral, fucosylated and sialylated forms, allows them to interact with the immune system in various ways. Clinically, HMOs impact allergic diseases, reducing autoimmune and inflammatory responses, and offer beneficial support to the preterm infant immune health. This review examines the HMO composition and associated immunomodulatory effects, including interactions with immune cell receptors and gut-associated immune responses. These immunomodulatory properties highlight the potential for HMO use in early stage immune development and for use as novel immunotherapeutics. HMO research is rapidly evolving and promises innovative treatments for immune-related conditions and improved health outcomes.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1523829/fullhuman milk oligosaccharides (HMOs)immunomodulationimmune cell receptorsgut-associated immune responsesautoimmune and inflammatory diseases |
| spellingShingle | Alanna S. Slater Alanna S. Slater Rita M. Hickey Gavin P. Davey Interactions of human milk oligosaccharides with the immune system Frontiers in Immunology human milk oligosaccharides (HMOs) immunomodulation immune cell receptors gut-associated immune responses autoimmune and inflammatory diseases |
| title | Interactions of human milk oligosaccharides with the immune system |
| title_full | Interactions of human milk oligosaccharides with the immune system |
| title_fullStr | Interactions of human milk oligosaccharides with the immune system |
| title_full_unstemmed | Interactions of human milk oligosaccharides with the immune system |
| title_short | Interactions of human milk oligosaccharides with the immune system |
| title_sort | interactions of human milk oligosaccharides with the immune system |
| topic | human milk oligosaccharides (HMOs) immunomodulation immune cell receptors gut-associated immune responses autoimmune and inflammatory diseases |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1523829/full |
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