Viral Infection in Glioblastoma: Immunohistochemistry in Detection of Cytomegalovirus, Epstein-Barr and Herpes Simplex – 1 Virus
Introduction: Glioblastoma (GB) is the most aggressive glial tumor of the brain with a dismal prognosis. Studies conducted during the last two decades highlighted neurotropic viruses as a risk factors involved in development of glioblastoma. Authors present an immunohistological study conducted in a...
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Faculty of Medicine Osijek
2025-02-01
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| Series: | Southeastern European Medical Journal |
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| Online Access: | https://seemedj.mefos.unios.hr/index.php/seemedj/article/view/338/211 |
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| author | Nenad Koruga Tatjana Pekmezović Ilijan Tomaš Jasmina Rajc Alen Rončević Anamarija Soldo Koruga |
| author_facet | Nenad Koruga Tatjana Pekmezović Ilijan Tomaš Jasmina Rajc Alen Rončević Anamarija Soldo Koruga |
| author_sort | Nenad Koruga |
| collection | DOAJ |
| description | Introduction: Glioblastoma (GB) is the most aggressive glial tumor of the brain with a dismal prognosis. Studies conducted during the last two decades highlighted neurotropic viruses as a risk factors involved in development of glioblastoma. Authors present an immunohistological study conducted in a single center on sixty-three archive paraffin-embedded samples of GB.
Patients and methods: The tissues were tested using immunohistochemistry in a homogenous group of sixty-three glioblastoma paraffin-embedded tissues for the presence of Cytomegalovirus (CMV), Epstein-Barr virus (EBV) and herpes simplex virus type 1 (HSV-1).
Results: Three species of herpes viruses were tested: HSV-1, Epstein-Barr virus (EBV) and Cytomegalovirus using the standard automatized immunohistochemistry. According to the IRS score, there were six samples of HSV-1 regarded as IRS 2 and five IRS 1 samples of the same virus. EBV and CMV were negative.
Conclusion: The result of our study identified HSV-1 as the most prominent neurotropic virus among population surgically treated of GB. Further studies are necessary to confirm its possible oncomodulatory role. |
| format | Article |
| id | doaj-art-ff26c2dc1d3e44e4ab732b986159c082 |
| institution | DOAJ |
| issn | 2459-9484 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Faculty of Medicine Osijek |
| record_format | Article |
| series | Southeastern European Medical Journal |
| spelling | doaj-art-ff26c2dc1d3e44e4ab732b986159c0822025-08-20T03:01:10ZengFaculty of Medicine OsijekSoutheastern European Medical Journal2459-94842025-02-0182465510.26332/seemedj.v8i2.338Viral Infection in Glioblastoma: Immunohistochemistry in Detection of Cytomegalovirus, Epstein-Barr and Herpes Simplex – 1 VirusNenad Koruga0Tatjana Pekmezović1Ilijan Tomaš2Jasmina Rajc3Alen Rončević4Anamarija Soldo Koruga5Department of Neurosurgery, University Hospital Center Osijek, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, CroatiaInstitute of Epidemiology, Faculty of Medicine, University of Belgrade, SerbiaFaculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Department of Oncology, University Hospital Center Osijek, CroatiaFaculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Department of Pathology and Forensic medicine, University Hospital Center Osijek, CroatiaDepartment of Neurosurgery, University Hospital Center Osijek, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, CroatiaFaculty of Medicine, Josip Juraj Strossmayer University of Osijek, Croatia; Department of Neurology, University Hospital Center Osijek, CroatiaIntroduction: Glioblastoma (GB) is the most aggressive glial tumor of the brain with a dismal prognosis. Studies conducted during the last two decades highlighted neurotropic viruses as a risk factors involved in development of glioblastoma. Authors present an immunohistological study conducted in a single center on sixty-three archive paraffin-embedded samples of GB. Patients and methods: The tissues were tested using immunohistochemistry in a homogenous group of sixty-three glioblastoma paraffin-embedded tissues for the presence of Cytomegalovirus (CMV), Epstein-Barr virus (EBV) and herpes simplex virus type 1 (HSV-1). Results: Three species of herpes viruses were tested: HSV-1, Epstein-Barr virus (EBV) and Cytomegalovirus using the standard automatized immunohistochemistry. According to the IRS score, there were six samples of HSV-1 regarded as IRS 2 and five IRS 1 samples of the same virus. EBV and CMV were negative. Conclusion: The result of our study identified HSV-1 as the most prominent neurotropic virus among population surgically treated of GB. Further studies are necessary to confirm its possible oncomodulatory role. https://seemedj.mefos.unios.hr/index.php/seemedj/article/view/338/211cytomegalovirusepstein-barr virusherpes simplex virusglioblastomaneurotropic virusesoncogenic viruses |
| spellingShingle | Nenad Koruga Tatjana Pekmezović Ilijan Tomaš Jasmina Rajc Alen Rončević Anamarija Soldo Koruga Viral Infection in Glioblastoma: Immunohistochemistry in Detection of Cytomegalovirus, Epstein-Barr and Herpes Simplex – 1 Virus Southeastern European Medical Journal cytomegalovirus epstein-barr virus herpes simplex virus glioblastoma neurotropic viruses oncogenic viruses |
| title | Viral Infection in Glioblastoma: Immunohistochemistry in Detection of Cytomegalovirus, Epstein-Barr and Herpes Simplex – 1 Virus |
| title_full | Viral Infection in Glioblastoma: Immunohistochemistry in Detection of Cytomegalovirus, Epstein-Barr and Herpes Simplex – 1 Virus |
| title_fullStr | Viral Infection in Glioblastoma: Immunohistochemistry in Detection of Cytomegalovirus, Epstein-Barr and Herpes Simplex – 1 Virus |
| title_full_unstemmed | Viral Infection in Glioblastoma: Immunohistochemistry in Detection of Cytomegalovirus, Epstein-Barr and Herpes Simplex – 1 Virus |
| title_short | Viral Infection in Glioblastoma: Immunohistochemistry in Detection of Cytomegalovirus, Epstein-Barr and Herpes Simplex – 1 Virus |
| title_sort | viral infection in glioblastoma immunohistochemistry in detection of cytomegalovirus epstein barr and herpes simplex 1 virus |
| topic | cytomegalovirus epstein-barr virus herpes simplex virus glioblastoma neurotropic viruses oncogenic viruses |
| url | https://seemedj.mefos.unios.hr/index.php/seemedj/article/view/338/211 |
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