Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?
Background. Cystic fibrosis-associated liver disease (CFLD) is a major cause of death. The objective of our retrospective study was to describe the relevance of magnetic resonance imaging (MRI) and liver stiffness measurement (LSM) for CFLD evaluation. Methods. All cystic fibrosis adult patients eva...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2016/4592702 |
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| author | C. Lemaitre S. Dominique E. Billoud M. Eliezer H. Montialoux M. Quillard G. Riachi E. Koning H. Morisse-Pradier G. Savoye C. Savoye-Collet O. Goria |
| author_facet | C. Lemaitre S. Dominique E. Billoud M. Eliezer H. Montialoux M. Quillard G. Riachi E. Koning H. Morisse-Pradier G. Savoye C. Savoye-Collet O. Goria |
| author_sort | C. Lemaitre |
| collection | DOAJ |
| description | Background. Cystic fibrosis-associated liver disease (CFLD) is a major cause of death. The objective of our retrospective study was to describe the relevance of magnetic resonance imaging (MRI) and liver stiffness measurement (LSM) for CFLD evaluation. Methods. All cystic fibrosis adult patients evaluated by MRI and LSM were included. MR signs of portal hypertension (PHT), dysmorphia, or cholangitis were collected and LSM expressed in kPa and Metavir. Results. Of 25 patients, 52% had abnormal MRI. Median LSM was 5.7 kPa (3.4–9.9). Three patients had F2 score and one had F3 score. In patients with PHT, LSM was 7.85 kPa (3.7–9.9) compared to 5 (3.4–7.5) in others, p=0.02. In patients with abnormal liver function tests, 50% had increased LSM (≥F2), whereas 94% with normal tests had normal LSM (p=0.04). Seven patients had abnormal MRI despite normal ultrasonography. Conclusions. MRI and LSM provide useful information on CFLD and may help to screen patients with PHT. |
| format | Article |
| id | doaj-art-ff1f5e7794c6425ab4cd4a22460bad44 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-ff1f5e7794c6425ab4cd4a22460bad442025-02-03T01:06:14ZengWileyCanadian Respiratory Journal1198-22411916-72452016-01-01201610.1155/2016/45927024592702Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease?C. Lemaitre0S. Dominique1E. Billoud2M. Eliezer3H. Montialoux4M. Quillard5G. Riachi6E. Koning7H. Morisse-Pradier8G. Savoye9C. Savoye-Collet10O. Goria11Department of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, FranceDepartment of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, FranceDepartment of Gastroenterology, Le Havre General Hospital, Le Havre, FranceDepartment of Radiology, Rouen University Hospital, Rouen, FranceDepartment of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, FranceClinical Biology Institute, Rouen University Hospital, Rouen, FranceDepartment of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, FranceDepartment of Radiology, Rouen University Hospital, Rouen, FranceDepartment of Pneumology, Adult Cystic Fibrosis Centre, Rouen University Hospital, Rouen, FranceDepartment of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, FranceDepartment of Radiology, Rouen University Hospital, Rouen, FranceDepartment of Gastroenterology and Hepatology, Rouen University Hospital, Rouen, FranceBackground. Cystic fibrosis-associated liver disease (CFLD) is a major cause of death. The objective of our retrospective study was to describe the relevance of magnetic resonance imaging (MRI) and liver stiffness measurement (LSM) for CFLD evaluation. Methods. All cystic fibrosis adult patients evaluated by MRI and LSM were included. MR signs of portal hypertension (PHT), dysmorphia, or cholangitis were collected and LSM expressed in kPa and Metavir. Results. Of 25 patients, 52% had abnormal MRI. Median LSM was 5.7 kPa (3.4–9.9). Three patients had F2 score and one had F3 score. In patients with PHT, LSM was 7.85 kPa (3.7–9.9) compared to 5 (3.4–7.5) in others, p=0.02. In patients with abnormal liver function tests, 50% had increased LSM (≥F2), whereas 94% with normal tests had normal LSM (p=0.04). Seven patients had abnormal MRI despite normal ultrasonography. Conclusions. MRI and LSM provide useful information on CFLD and may help to screen patients with PHT.http://dx.doi.org/10.1155/2016/4592702 |
| spellingShingle | C. Lemaitre S. Dominique E. Billoud M. Eliezer H. Montialoux M. Quillard G. Riachi E. Koning H. Morisse-Pradier G. Savoye C. Savoye-Collet O. Goria Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease? Canadian Respiratory Journal |
| title | Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease? |
| title_full | Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease? |
| title_fullStr | Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease? |
| title_full_unstemmed | Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease? |
| title_short | Relevance of 3D Cholangiography and Transient Elastography to Assess Cystic Fibrosis-Associated Liver Disease? |
| title_sort | relevance of 3d cholangiography and transient elastography to assess cystic fibrosis associated liver disease |
| url | http://dx.doi.org/10.1155/2016/4592702 |
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