Health-Related Quality of Life and Its Influencing Factors in Patients with Hepatitis B: A Cross-Sectional Assessment in Southeastern China
Health-related quality of life (HRQoL) is an important aspect in the management of patients with hepatitis B (HB), which remains a serious health problem in China. There have been relatively few HRQoL studies involving Chinese patients with HB. The aim of this study was to analyze HRQoL in patients...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2021/9937591 |
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| author | Ping Chen Fen Zhang Yiqun Shen Yubo Cai Chaolei Jin Yan Li Mingmin Tu Weizhen Zhang Yu Wang Shi-Feng Zhang Jiangyun Wang Lanjuan Li |
| author_facet | Ping Chen Fen Zhang Yiqun Shen Yubo Cai Chaolei Jin Yan Li Mingmin Tu Weizhen Zhang Yu Wang Shi-Feng Zhang Jiangyun Wang Lanjuan Li |
| author_sort | Ping Chen |
| collection | DOAJ |
| description | Health-related quality of life (HRQoL) is an important aspect in the management of patients with hepatitis B (HB), which remains a serious health problem in China. There have been relatively few HRQoL studies involving Chinese patients with HB. The aim of this study was to analyze HRQoL in patients diagnosed with HB living in Zhejiang Province, China. A cross-sectional sample of 98 patients with chronic HB (CHB), 56 patients with advanced HB that have developed cirrhosis, and 48 healthy controls (HCs), all from Zhejiang Province, was used in this study. HRQoL was assessed using Short-Form 36 (SF-36) version 2, European quality of life questionnaire-5 dimensions (EQ-5D), and chronic liver disease questionnaire (CLDQ). Intergroup score differences were detected with U tests. Factors with a significant effect on HRQoL were identified with Spearman correlational analyses. Patients with HB (both groups) had lower SF-36 scores than HCs (p<0.01), with the exception of general health subscores. Patients with HB cirrhosis had the lowest scores in the EQ-5D visual analog scale (VAS) component. Furthermore, patients with HB cirrhosis had lower (p<0.01) CLDQ scores than patients with CHB. In our HB patient cohort, disease stage and income level were the factors most associated with HRQoL variables; age, education level, and marital status were, each, also significantly associated with some HRQoL variables in patients with HB in our study (p<0.05 or p<0.01). HRQoL is diminished in patients with HB in southeastern China. Disease stage and income emerged as key determinants of HRQoL scores. Augmenting social and medical supports for patients with HB, especially those with a socioeconomic status and an advanced disease stage, may help to enhance HRQoL. |
| format | Article |
| id | doaj-art-ff1d99840ee744d1ae3b94ee419509e0 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-ff1d99840ee744d1ae3b94ee419509e02025-02-03T01:04:33ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972021-01-01202110.1155/2021/99375919937591Health-Related Quality of Life and Its Influencing Factors in Patients with Hepatitis B: A Cross-Sectional Assessment in Southeastern ChinaPing Chen0Fen Zhang1Yiqun Shen2Yubo Cai3Chaolei Jin4Yan Li5Mingmin Tu6Weizhen Zhang7Yu Wang8Shi-Feng Zhang9Jiangyun Wang10Lanjuan Li11Department of Infectious Diseases, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou 310012, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, ChinaHuzhou Central Hospital, Affiliated Central Hospital Huzhou University, HuZhou 313000, ChinaSchool of Medicine, Zhejiang University, Hangzhou 310058, ChinaSchool of Clinical Medicine, Henan University, Kaifeng 475000, ChinaThe Academician Workstation, Zhengzhou Cancer Hospital of Henan University, Zhengzhou 450000, ChinaHangzhou Tongchuang Medical Laboratory, Hangzhou 310012, ChinaDepartment of Oncology, Zhengzhou Cancer Hospital of Henan University, Zhengzhou 450000, ChinaDepartment of Hematology, Zhengzhou Cancer Hospital of Henan University, Zhengzhou 450000, ChinaDepartment of Stomatology, Zhengzhou Cancer Hospital of Henan University, Zhengzhou 450000, ChinaDepartment of Cosmetic Surgery, Zhengzhou Cancer Hospital of Henan University, Zhengzhou 450000, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, ChinaHealth-related quality of life (HRQoL) is an important aspect in the management of patients with hepatitis B (HB), which remains a serious health problem in China. There have been relatively few HRQoL studies involving Chinese patients with HB. The aim of this study was to analyze HRQoL in patients diagnosed with HB living in Zhejiang Province, China. A cross-sectional sample of 98 patients with chronic HB (CHB), 56 patients with advanced HB that have developed cirrhosis, and 48 healthy controls (HCs), all from Zhejiang Province, was used in this study. HRQoL was assessed using Short-Form 36 (SF-36) version 2, European quality of life questionnaire-5 dimensions (EQ-5D), and chronic liver disease questionnaire (CLDQ). Intergroup score differences were detected with U tests. Factors with a significant effect on HRQoL were identified with Spearman correlational analyses. Patients with HB (both groups) had lower SF-36 scores than HCs (p<0.01), with the exception of general health subscores. Patients with HB cirrhosis had the lowest scores in the EQ-5D visual analog scale (VAS) component. Furthermore, patients with HB cirrhosis had lower (p<0.01) CLDQ scores than patients with CHB. In our HB patient cohort, disease stage and income level were the factors most associated with HRQoL variables; age, education level, and marital status were, each, also significantly associated with some HRQoL variables in patients with HB in our study (p<0.05 or p<0.01). HRQoL is diminished in patients with HB in southeastern China. Disease stage and income emerged as key determinants of HRQoL scores. Augmenting social and medical supports for patients with HB, especially those with a socioeconomic status and an advanced disease stage, may help to enhance HRQoL.http://dx.doi.org/10.1155/2021/9937591 |
| spellingShingle | Ping Chen Fen Zhang Yiqun Shen Yubo Cai Chaolei Jin Yan Li Mingmin Tu Weizhen Zhang Yu Wang Shi-Feng Zhang Jiangyun Wang Lanjuan Li Health-Related Quality of Life and Its Influencing Factors in Patients with Hepatitis B: A Cross-Sectional Assessment in Southeastern China Canadian Journal of Gastroenterology and Hepatology |
| title | Health-Related Quality of Life and Its Influencing Factors in Patients with Hepatitis B: A Cross-Sectional Assessment in Southeastern China |
| title_full | Health-Related Quality of Life and Its Influencing Factors in Patients with Hepatitis B: A Cross-Sectional Assessment in Southeastern China |
| title_fullStr | Health-Related Quality of Life and Its Influencing Factors in Patients with Hepatitis B: A Cross-Sectional Assessment in Southeastern China |
| title_full_unstemmed | Health-Related Quality of Life and Its Influencing Factors in Patients with Hepatitis B: A Cross-Sectional Assessment in Southeastern China |
| title_short | Health-Related Quality of Life and Its Influencing Factors in Patients with Hepatitis B: A Cross-Sectional Assessment in Southeastern China |
| title_sort | health related quality of life and its influencing factors in patients with hepatitis b a cross sectional assessment in southeastern china |
| url | http://dx.doi.org/10.1155/2021/9937591 |
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