Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine
Oxidative stress is intricately related to gastrointestinal diseases. Although both lactobacillus (LAB) and carnosine (CAR) contribute to combating oxidative stress and attenuating gastrointestinal disorders, little is known about the effects and mechanisms of their combined treatment. Here, we repo...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000295 |
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| author | Jian Qin Ziyi Luo Xu Yang Yunqing Zhang Huiying Li Conghui Wang Zhiqiang Zou Yue Ma Jing Ma Daoyou Yue Dipeng Zhao Sen Qin Rong Du |
| author_facet | Jian Qin Ziyi Luo Xu Yang Yunqing Zhang Huiying Li Conghui Wang Zhiqiang Zou Yue Ma Jing Ma Daoyou Yue Dipeng Zhao Sen Qin Rong Du |
| author_sort | Jian Qin |
| collection | DOAJ |
| description | Oxidative stress is intricately related to gastrointestinal diseases. Although both lactobacillus (LAB) and carnosine (CAR) contribute to combating oxidative stress and attenuating gastrointestinal disorders, little is known about the effects and mechanisms of their combined treatment. Here, we report the protective effects of LAB and/or CAR on the gastrointestinal tissues in normal or dexamethasone (Dex)-induced stress mice. The combination of LAB and CAR protected the structures of stomach and small intestine, alleviating the Dex-induced tissue damages. Additionally, this combined treatment increased the activity of antioxidant enzymes and up-regulated the expression of antioxidant genes in the Nrf2 signaling pathway in stress mice. Our study sheds light on the synergetic and complementary roles of LAB and CAR in maintaining the structural and functional integrity of stomach and small intestine, offering clues for understanding the regulation of antioxidant enzyme genes through the Nrf2 pathway as a potential mechanism. |
| format | Article |
| id | doaj-art-ff1a48b0ab3b48c8a493e1446ed0141f |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-ff1a48b0ab3b48c8a493e1446ed0141f2025-02-09T04:59:58ZengElsevierJournal of Functional Foods1756-46462025-02-01125106687Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestineJian Qin0Ziyi Luo1Xu Yang2Yunqing Zhang3Huiying Li4Conghui Wang5Zhiqiang Zou6Yue Ma7Jing Ma8Daoyou Yue9Dipeng Zhao10Sen Qin11Rong Du12College of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, China; Center of Experiment Teaching, Shanxi Agricultural University, Taigu 030801, Shanxi, ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, ChinaCollege of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, ChinaHenan Provincial Center for Animal Disease Prevention and Control, Zhengzhou 450000, Henan, ChinaDepartment of Medical Laboratory, Fenyang College of Shanxi Medical University, Fenyang, Shanxi 032200, China; Corresponding author at: Department of Medical Laboratory, Fenyang College of Shanxi Medical University, Fenyang, Shanxi 032200, China.School of Basic Medical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China; Corresponding author at: School of Basic Medical Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China.College of Veterinary Medicine, Shanxi Agricultural University, Taigu 030801, Shanxi, China; Corresponding author at: College of Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi 030801, China.Oxidative stress is intricately related to gastrointestinal diseases. Although both lactobacillus (LAB) and carnosine (CAR) contribute to combating oxidative stress and attenuating gastrointestinal disorders, little is known about the effects and mechanisms of their combined treatment. Here, we report the protective effects of LAB and/or CAR on the gastrointestinal tissues in normal or dexamethasone (Dex)-induced stress mice. The combination of LAB and CAR protected the structures of stomach and small intestine, alleviating the Dex-induced tissue damages. Additionally, this combined treatment increased the activity of antioxidant enzymes and up-regulated the expression of antioxidant genes in the Nrf2 signaling pathway in stress mice. Our study sheds light on the synergetic and complementary roles of LAB and CAR in maintaining the structural and functional integrity of stomach and small intestine, offering clues for understanding the regulation of antioxidant enzyme genes through the Nrf2 pathway as a potential mechanism.http://www.sciencedirect.com/science/article/pii/S1756464625000295LactobacillusCarnosineOxidative stressStomachSmall intestineMice |
| spellingShingle | Jian Qin Ziyi Luo Xu Yang Yunqing Zhang Huiying Li Conghui Wang Zhiqiang Zou Yue Ma Jing Ma Daoyou Yue Dipeng Zhao Sen Qin Rong Du Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine Journal of Functional Foods Lactobacillus Carnosine Oxidative stress Stomach Small intestine Mice |
| title | Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine |
| title_full | Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine |
| title_fullStr | Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine |
| title_full_unstemmed | Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine |
| title_short | Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine |
| title_sort | protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine |
| topic | Lactobacillus Carnosine Oxidative stress Stomach Small intestine Mice |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000295 |
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