Long-Term Oncological Outcomes Related to Lymphadenectomy in Clinical Stage I NSCLC: A Multicenter Retrospective Experience
Background: Lymphadenectomy is considered a key part of the radical treatment of resectable lung cancer, although its appropriate extension in early stages is a debated topic due to the great heterogeneity of studies in the literature. This study aims to evaluate the impact of lymphadenectomy extent...
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MDPI AG
2025-01-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/32/1/31 |
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| author | Beatrice Manfredini Carmelina Cristina Zirafa Alessandro Stefani Gaetano Romano Greta Alì Riccardo Morganti Ilaria Ceccarelli Federico Davini Pier Luigi Filosso Franca Melfi |
| author_facet | Beatrice Manfredini Carmelina Cristina Zirafa Alessandro Stefani Gaetano Romano Greta Alì Riccardo Morganti Ilaria Ceccarelli Federico Davini Pier Luigi Filosso Franca Melfi |
| author_sort | Beatrice Manfredini |
| collection | DOAJ |
| description | Background: Lymphadenectomy is considered a key part of the radical treatment of resectable lung cancer, although its appropriate extension in early stages is a debated topic due to the great heterogeneity of studies in the literature. This study aims to evaluate the impact of lymphadenectomy extent on survival and recurrence in the treatment of early-stage NSCLC patients undergoing lobectomy and lymph node dissection. Methods: Data from clinical stage I NSCLC patients undergoing lobectomy and hilar-mediastinal lymphadenectomy at two thoracic surgery centers from 2016 to 2019 were retrospectively evaluated. Information regarding perioperative outcomes and lymphadenectomy details was collected and analyzed, and their impact on OS, CSS, and DFS was assessed. Results: During the period under review, 323 patients with stage cI lung cancer underwent lobectomy with lymphadenectomy. Statistical analysis showed that the evaluated lymph nodal factors (mean number of lymph nodes removed and number and type of lymph node station explored) did not statistically significantly impact OS, CSS, and DFS at a median follow-up of 59 months (IQR 45–71). Conclusions: The results of this study suggest that a less invasive procedure than systematic lymphadenectomy could be performed in early-stage cases with adequate preoperative staging. |
| format | Article |
| id | doaj-art-ff16daa1c6164fa2bd5314371d011f3b |
| institution | Kabale University |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-ff16daa1c6164fa2bd5314371d011f3b2025-01-24T13:28:25ZengMDPI AGCurrent Oncology1198-00521718-77292025-01-013213110.3390/curroncol32010031Long-Term Oncological Outcomes Related to Lymphadenectomy in Clinical Stage I NSCLC: A Multicenter Retrospective ExperienceBeatrice Manfredini0Carmelina Cristina Zirafa1Alessandro Stefani2Gaetano Romano3Greta Alì4Riccardo Morganti5Ilaria Ceccarelli6Federico Davini7Pier Luigi Filosso8Franca Melfi9Minimally Invasive and Robotic Thoracic Surgery, Surgical, Medical, Molecular and Critical Care Pathology Department, University of Pisa, 56126 Pisa, ItalyMinimally Invasive and Robotic Thoracic Surgery, Surgical, Medical, Molecular and Critical Care Pathology Department, University of Pisa, 56126 Pisa, ItalyUnit of Thoracic Surgery, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41121 Modena, ItalyMinimally Invasive and Robotic Thoracic Surgery, Surgical, Medical, Molecular and Critical Care Pathology Department, University of Pisa, 56126 Pisa, ItalyPathological Anatomy, Surgical, Medical, Molecular and Critical Care Pathology Department, University Hospital of Pisa, 56126 Pisa, ItalySection of Statistics, University Hospital of Pisa, 56126 Pisa, ItalyMinimally Invasive and Robotic Thoracic Surgery, Surgical, Medical, Molecular and Critical Care Pathology Department, University of Pisa, 56126 Pisa, ItalyMinimally Invasive and Robotic Thoracic Surgery, Surgical, Medical, Molecular and Critical Care Pathology Department, University of Pisa, 56126 Pisa, ItalyUnit of Thoracic Surgery, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, 41121 Modena, ItalyUnit of Thoracic Surgery, Department of Pharmacy and Health and Nutrition Sciences, University of Calabria, 87036 Rende, ItalyBackground: Lymphadenectomy is considered a key part of the radical treatment of resectable lung cancer, although its appropriate extension in early stages is a debated topic due to the great heterogeneity of studies in the literature. This study aims to evaluate the impact of lymphadenectomy extent on survival and recurrence in the treatment of early-stage NSCLC patients undergoing lobectomy and lymph node dissection. Methods: Data from clinical stage I NSCLC patients undergoing lobectomy and hilar-mediastinal lymphadenectomy at two thoracic surgery centers from 2016 to 2019 were retrospectively evaluated. Information regarding perioperative outcomes and lymphadenectomy details was collected and analyzed, and their impact on OS, CSS, and DFS was assessed. Results: During the period under review, 323 patients with stage cI lung cancer underwent lobectomy with lymphadenectomy. Statistical analysis showed that the evaluated lymph nodal factors (mean number of lymph nodes removed and number and type of lymph node station explored) did not statistically significantly impact OS, CSS, and DFS at a median follow-up of 59 months (IQR 45–71). Conclusions: The results of this study suggest that a less invasive procedure than systematic lymphadenectomy could be performed in early-stage cases with adequate preoperative staging.https://www.mdpi.com/1718-7729/32/1/31early stageclinical stage INSCLClymphadenectomy |
| spellingShingle | Beatrice Manfredini Carmelina Cristina Zirafa Alessandro Stefani Gaetano Romano Greta Alì Riccardo Morganti Ilaria Ceccarelli Federico Davini Pier Luigi Filosso Franca Melfi Long-Term Oncological Outcomes Related to Lymphadenectomy in Clinical Stage I NSCLC: A Multicenter Retrospective Experience Current Oncology early stage clinical stage I NSCLC lymphadenectomy |
| title | Long-Term Oncological Outcomes Related to Lymphadenectomy in Clinical Stage I NSCLC: A Multicenter Retrospective Experience |
| title_full | Long-Term Oncological Outcomes Related to Lymphadenectomy in Clinical Stage I NSCLC: A Multicenter Retrospective Experience |
| title_fullStr | Long-Term Oncological Outcomes Related to Lymphadenectomy in Clinical Stage I NSCLC: A Multicenter Retrospective Experience |
| title_full_unstemmed | Long-Term Oncological Outcomes Related to Lymphadenectomy in Clinical Stage I NSCLC: A Multicenter Retrospective Experience |
| title_short | Long-Term Oncological Outcomes Related to Lymphadenectomy in Clinical Stage I NSCLC: A Multicenter Retrospective Experience |
| title_sort | long term oncological outcomes related to lymphadenectomy in clinical stage i nsclc a multicenter retrospective experience |
| topic | early stage clinical stage I NSCLC lymphadenectomy |
| url | https://www.mdpi.com/1718-7729/32/1/31 |
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