Safety and efficacy evaluation of intracerebroventricular human neural stem cell transplantation in SOD1 mice as a novel approach for ALS

Safety and efficacy evaluation of intracerebroventricular human neural stem cell transplantation in SOD1 mice as a novel approach for ALS

Abstract Background Neural stem cell (NSC) transplantation holds promising therapeutic potential for neurodegenerative disorders like amyotrophic lateral sclerosis (ALS). However, pre-clinical studies and early-phase clinical trials have faced challenges hindering the effective clinical translation...

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Main Authors: Ivan Lombardi, Clelia Ferrero, Edvige Vulcano, Daniela Maria Rasà, Maurizio Gelati, Diego Pastor, Rose Mary Carletti, Silvia de la Morena, Daniela Celeste Profico, Sabrina Longobardi, Elisa Lazzarino, Elisa Perciballi, Jessica Diana Rosati, Salvador Martinez, Alessandro Vercelli, Angelo Luigi Vescovi, Marina Boido, Daniela Ferrari
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Cell therapy
Neural stem cells
Transplantation
ALS
Intracerebroventricular
SOD1 model
Online Access:https://doi.org/10.1186/s12967-025-06529-9
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