Novel 3D printed capsule to work as an auxiliary for enteric-coating for gastroprotective drug delivery system.
In the current research work, 3d printed capsules were printed by using FDM based 3D printer. A model drug punched into matrix tablets was put inside and encapsulated in the capsule. It was compared with the highly advanced ready-to-fill enteric-coated capsule Eudracap™ capsule. Solid Works and slic...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-11-01
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| Series: | Annals of 3D Printed Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666964124000341 |
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| author | Saniya Jawed Satish CS |
| author_facet | Saniya Jawed Satish CS |
| author_sort | Saniya Jawed |
| collection | DOAJ |
| description | In the current research work, 3d printed capsules were printed by using FDM based 3D printer. A model drug punched into matrix tablets was put inside and encapsulated in the capsule. It was compared with the highly advanced ready-to-fill enteric-coated capsule Eudracap™ capsule. Solid Works and slicing software were used to design and cast off the shape of the capsule shell. The design of the cap and body was made and capsules were printed accordingly. All were evaluated for acid uptake and disintegration tests. In an acidic medium at pH 1.2, it has not been disintegrated or opened. While in the intestinal pH at 6.8 body and cap got separated after 45 ± 05 min. All sizes of capsules were also assessed for dosage form they can uphold. This could be a good option for customized drug delivery for human and animal studies. |
| format | Article |
| id | doaj-art-ff0f54f3bba041e7a90dbe4a70dd083a |
| institution | Kabale University |
| issn | 2666-9641 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of 3D Printed Medicine |
| spelling | doaj-art-ff0f54f3bba041e7a90dbe4a70dd083a2024-11-18T04:33:42ZengElsevierAnnals of 3D Printed Medicine2666-96412024-11-0116100176Novel 3D printed capsule to work as an auxiliary for enteric-coating for gastroprotective drug delivery system.Saniya Jawed0Satish CS1Corresponding author at: Assistant Professor, PESU Institute of Pharmacy, PES University, EC Campus, Bangalore, India.; PESU Institute of Pharmacy, PES University, EC Campus, Bangalore, 560100, IndiaPESU Institute of Pharmacy, PES University, EC Campus, Bangalore, 560100, IndiaIn the current research work, 3d printed capsules were printed by using FDM based 3D printer. A model drug punched into matrix tablets was put inside and encapsulated in the capsule. It was compared with the highly advanced ready-to-fill enteric-coated capsule Eudracap™ capsule. Solid Works and slicing software were used to design and cast off the shape of the capsule shell. The design of the cap and body was made and capsules were printed accordingly. All were evaluated for acid uptake and disintegration tests. In an acidic medium at pH 1.2, it has not been disintegrated or opened. While in the intestinal pH at 6.8 body and cap got separated after 45 ± 05 min. All sizes of capsules were also assessed for dosage form they can uphold. This could be a good option for customized drug delivery for human and animal studies.http://www.sciencedirect.com/science/article/pii/S26669641240003413D printingCustomized capsule shell, FDM (fused deposition modeling)Enteric-coating |
| spellingShingle | Saniya Jawed Satish CS Novel 3D printed capsule to work as an auxiliary for enteric-coating for gastroprotective drug delivery system. Annals of 3D Printed Medicine 3D printing Customized capsule shell, FDM (fused deposition modeling) Enteric-coating |
| title | Novel 3D printed capsule to work as an auxiliary for enteric-coating for gastroprotective drug delivery system. |
| title_full | Novel 3D printed capsule to work as an auxiliary for enteric-coating for gastroprotective drug delivery system. |
| title_fullStr | Novel 3D printed capsule to work as an auxiliary for enteric-coating for gastroprotective drug delivery system. |
| title_full_unstemmed | Novel 3D printed capsule to work as an auxiliary for enteric-coating for gastroprotective drug delivery system. |
| title_short | Novel 3D printed capsule to work as an auxiliary for enteric-coating for gastroprotective drug delivery system. |
| title_sort | novel 3d printed capsule to work as an auxiliary for enteric coating for gastroprotective drug delivery system |
| topic | 3D printing Customized capsule shell, FDM (fused deposition modeling) Enteric-coating |
| url | http://www.sciencedirect.com/science/article/pii/S2666964124000341 |
| work_keys_str_mv | AT saniyajawed novel3dprintedcapsuletoworkasanauxiliaryforentericcoatingforgastroprotectivedrugdeliverysystem AT satishcs novel3dprintedcapsuletoworkasanauxiliaryforentericcoatingforgastroprotectivedrugdeliverysystem |