Antisynthetase syndrome with anti-glycyl tRNA synthetase antibodies in a patient with axial spondyloarthritis treated with tumor necrosis factor-α inhibitors
We present a case of interstitial lung disease arising in the course of antisynthetase syndrome (ASSD) in a patient with axial spondyloarthritis (ax-SpA) undergoing tumor necrosis factor-α (TNF-α) inhibitors therapy. Only two cases of ASSD in ax-SpA patients have been described in the literature, a...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2025-02-01
|
| Series: | Reumatismo |
| Subjects: | |
| Online Access: | https://www.reumatismo.org/reuma/article/view/1756 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823859514650132480 |
|---|---|
| author | Maria Iacovantuono Chiara Bonini Ernesto Di Biase Vinicio Magliacani Gian Domenico Sebastiani |
| author_facet | Maria Iacovantuono Chiara Bonini Ernesto Di Biase Vinicio Magliacani Gian Domenico Sebastiani |
| author_sort | Maria Iacovantuono |
| collection | DOAJ |
| description |
We present a case of interstitial lung disease arising in the course of antisynthetase syndrome (ASSD) in a patient with axial spondyloarthritis (ax-SpA) undergoing tumor necrosis factor-α (TNF-α) inhibitors therapy. Only two cases of ASSD in ax-SpA patients have been described in the literature, although with a different autoantibody profile. Only in one case, ASSD manifested with lung involvement, without the possible implication of TNF-α inhibitors in the pathogenesis, as it occurred concurrently with spondyloarthritis. Our case is the first to emphasize the coexistence of ASSD with anti-glycyl tRNA synthetase antibodies and ax-SpA, reminding us of the possible, although rare, adverse effects on the lungs with TNF-α inhibitors.
|
| format | Article |
| id | doaj-art-ff0e538b3bf44a0e963176755a53816a |
| institution | Kabale University |
| issn | 0048-7449 2240-2683 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Reumatismo |
| spelling | doaj-art-ff0e538b3bf44a0e963176755a53816a2025-02-11T02:34:56ZengPAGEPress PublicationsReumatismo0048-74492240-26832025-02-0110.4081/reumatismo.2025.1756Antisynthetase syndrome with anti-glycyl tRNA synthetase antibodies in a patient with axial spondyloarthritis treated with tumor necrosis factor-α inhibitorsMaria Iacovantuono0https://orcid.org/0009-0002-4963-0663Chiara Bonini1Ernesto Di Biase2Vinicio Magliacani3Gian Domenico Sebastiani4 Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome “Tor Vergata”; Rheumatology Unit, AO San Camillo-Forlanini, RomeRheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome “Tor Vergata”; Rheumatology Unit, AO San Camillo-Forlanini, RomeUnit of Bronchopneumology, AO San Camillo-Forlanini, RomeSTIRS Operative Unit, AO San Camillo- Forlanini, RomeRheumatology Unit, AO San Camillo-Forlanini, Rome We present a case of interstitial lung disease arising in the course of antisynthetase syndrome (ASSD) in a patient with axial spondyloarthritis (ax-SpA) undergoing tumor necrosis factor-α (TNF-α) inhibitors therapy. Only two cases of ASSD in ax-SpA patients have been described in the literature, although with a different autoantibody profile. Only in one case, ASSD manifested with lung involvement, without the possible implication of TNF-α inhibitors in the pathogenesis, as it occurred concurrently with spondyloarthritis. Our case is the first to emphasize the coexistence of ASSD with anti-glycyl tRNA synthetase antibodies and ax-SpA, reminding us of the possible, although rare, adverse effects on the lungs with TNF-α inhibitors. https://www.reumatismo.org/reuma/article/view/1756Antisynthetase syndromeaxial-spondiloarthritisanti TNF-α drugsinterstitial lung disease |
| spellingShingle | Maria Iacovantuono Chiara Bonini Ernesto Di Biase Vinicio Magliacani Gian Domenico Sebastiani Antisynthetase syndrome with anti-glycyl tRNA synthetase antibodies in a patient with axial spondyloarthritis treated with tumor necrosis factor-α inhibitors Reumatismo Antisynthetase syndrome axial-spondiloarthritis anti TNF-α drugs interstitial lung disease |
| title | Antisynthetase syndrome with anti-glycyl tRNA synthetase antibodies in a patient with axial spondyloarthritis treated with tumor necrosis factor-α inhibitors |
| title_full | Antisynthetase syndrome with anti-glycyl tRNA synthetase antibodies in a patient with axial spondyloarthritis treated with tumor necrosis factor-α inhibitors |
| title_fullStr | Antisynthetase syndrome with anti-glycyl tRNA synthetase antibodies in a patient with axial spondyloarthritis treated with tumor necrosis factor-α inhibitors |
| title_full_unstemmed | Antisynthetase syndrome with anti-glycyl tRNA synthetase antibodies in a patient with axial spondyloarthritis treated with tumor necrosis factor-α inhibitors |
| title_short | Antisynthetase syndrome with anti-glycyl tRNA synthetase antibodies in a patient with axial spondyloarthritis treated with tumor necrosis factor-α inhibitors |
| title_sort | antisynthetase syndrome with anti glycyl trna synthetase antibodies in a patient with axial spondyloarthritis treated with tumor necrosis factor α inhibitors |
| topic | Antisynthetase syndrome axial-spondiloarthritis anti TNF-α drugs interstitial lung disease |
| url | https://www.reumatismo.org/reuma/article/view/1756 |
| work_keys_str_mv | AT mariaiacovantuono antisynthetasesyndromewithantiglycyltrnasynthetaseantibodiesinapatientwithaxialspondyloarthritistreatedwithtumornecrosisfactorainhibitors AT chiarabonini antisynthetasesyndromewithantiglycyltrnasynthetaseantibodiesinapatientwithaxialspondyloarthritistreatedwithtumornecrosisfactorainhibitors AT ernestodibiase antisynthetasesyndromewithantiglycyltrnasynthetaseantibodiesinapatientwithaxialspondyloarthritistreatedwithtumornecrosisfactorainhibitors AT viniciomagliacani antisynthetasesyndromewithantiglycyltrnasynthetaseantibodiesinapatientwithaxialspondyloarthritistreatedwithtumornecrosisfactorainhibitors AT giandomenicosebastiani antisynthetasesyndromewithantiglycyltrnasynthetaseantibodiesinapatientwithaxialspondyloarthritistreatedwithtumornecrosisfactorainhibitors |