Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer
Macrophages are critical mediators of inflammation and important regulators of developmental processes. As a key phagocytic cell type, macrophages evolved as part of the innate immune system to engulf and process cell debris and pathogens. Macrophages produce factors that act directly on their micro...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/4549676 |
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| _version_ | 1850161659588378624 |
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| author | Nicholas J. Brady Pavlina Chuntova Kathryn L. Schwertfeger |
| author_facet | Nicholas J. Brady Pavlina Chuntova Kathryn L. Schwertfeger |
| author_sort | Nicholas J. Brady |
| collection | DOAJ |
| description | Macrophages are critical mediators of inflammation and important regulators of developmental processes. As a key phagocytic cell type, macrophages evolved as part of the innate immune system to engulf and process cell debris and pathogens. Macrophages produce factors that act directly on their microenvironment and also bridge innate immune responses to the adaptive immune system. Resident macrophages are important for acting as sensors for tissue damage and maintaining tissue homeostasis. It is now well-established that macrophages are an integral component of the breast tumor microenvironment, where they contribute to tumor growth and progression, likely through many of the mechanisms that are utilized during normal wound healing responses. Because macrophages contribute to normal mammary gland development and breast cancer growth and progression, this review will discuss both resident mammary gland macrophages and tumor-associated macrophages with an emphasis on describing how macrophages interact with their surrounding environment during normal development and in the context of cancer. |
| format | Article |
| id | doaj-art-ff083491ddf444f2b2b8b3de473c0e59 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-ff083491ddf444f2b2b8b3de473c0e592025-08-20T02:22:45ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/45496764549676Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast CancerNicholas J. Brady0Pavlina Chuntova1Kathryn L. Schwertfeger2Microbiology, Immunology and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, MN 55455, USAMicrobiology, Immunology and Cancer Biology Graduate Program, University of Minnesota, Minneapolis, MN 55455, USADepartment of Lab Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USAMacrophages are critical mediators of inflammation and important regulators of developmental processes. As a key phagocytic cell type, macrophages evolved as part of the innate immune system to engulf and process cell debris and pathogens. Macrophages produce factors that act directly on their microenvironment and also bridge innate immune responses to the adaptive immune system. Resident macrophages are important for acting as sensors for tissue damage and maintaining tissue homeostasis. It is now well-established that macrophages are an integral component of the breast tumor microenvironment, where they contribute to tumor growth and progression, likely through many of the mechanisms that are utilized during normal wound healing responses. Because macrophages contribute to normal mammary gland development and breast cancer growth and progression, this review will discuss both resident mammary gland macrophages and tumor-associated macrophages with an emphasis on describing how macrophages interact with their surrounding environment during normal development and in the context of cancer.http://dx.doi.org/10.1155/2016/4549676 |
| spellingShingle | Nicholas J. Brady Pavlina Chuntova Kathryn L. Schwertfeger Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer Mediators of Inflammation |
| title | Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer |
| title_full | Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer |
| title_fullStr | Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer |
| title_full_unstemmed | Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer |
| title_short | Macrophages: Regulators of the Inflammatory Microenvironment during Mammary Gland Development and Breast Cancer |
| title_sort | macrophages regulators of the inflammatory microenvironment during mammary gland development and breast cancer |
| url | http://dx.doi.org/10.1155/2016/4549676 |
| work_keys_str_mv | AT nicholasjbrady macrophagesregulatorsoftheinflammatorymicroenvironmentduringmammaryglanddevelopmentandbreastcancer AT pavlinachuntova macrophagesregulatorsoftheinflammatorymicroenvironmentduringmammaryglanddevelopmentandbreastcancer AT kathrynlschwertfeger macrophagesregulatorsoftheinflammatorymicroenvironmentduringmammaryglanddevelopmentandbreastcancer |