Postoperative adjuvant hepatic arterial infusion chemotherapy with gemcitabine-cisplatin sequential capecitabine combined with PDL1 inhibitors in resected high-risk intrahepatic cholangiocarcinom: study protocol for a prospective, multicenter, single-arm, phase 2 trial (HgcCP trial)

Postoperative adjuvant hepatic arterial infusion chemotherapy with gemcitabine-cisplatin sequential capecitabine combined with PDL1 inhibitors in resected high-risk intrahepatic cholangiocarcinom: study protocol for a prospective, multicenter, single-arm, phase 2 trial (HgcCP trial)

BackgroundAlthough capecitabine is recommended for postoperative adjuvant treatment of biliary tract cancers (BTC), no studies have specifically focused on the postoperative adjuvant treatment of intrahepatic cholangiocarcinoma (ICC). In recent years, the combination of PD-L1 inhibitors and gemcitab...

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Bibliographic Details
Main Authors: Ying Yang, Qing-Yun Xie, Tao Lv, Jiayin Yang, Hai-Peng Yu, Xin Zheng, Hui Zhang, Chang Liu, Hong Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Oncology
Subjects:
intrahepatic cholangiocarcinoma
adjuvant therapy
hepatic arterial infusion chemotherapy
immunotherapy
chemotherapy
phase 2 study
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1584007/full
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