An integrative phenotype-structured partial differential equation model for the population dynamics of epithelial-mesenchymal transition

An integrative phenotype-structured partial differential equation model for the population dynamics of epithelial-mesenchymal transition

Abstract Phenotypic heterogeneity along the epithelial-mesenchymal (E-M) axis contributes to cancer metastasis and drug resistance. Recent experimental efforts have collated detailed time-course data on the emergence and dynamics of E-M heterogeneity in a cell population. However, it remains unclear...

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Bibliographic Details
Main Authors: Jules Guilberteau, Paras Jain, Mohit Kumar Jolly, Camille Pouchol, Nastassia Pouradier Duteil
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-025-00502-4
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