α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model

Abstract Understanding the progression of α‐synuclein pathology in neurodegenerative diseases such as Parkinson's disease (PD) is a longstanding challenge. Here, a novel midbrain–hindbrain‐assembloid model that recapitulates the spread of α‐synuclein pathology observed in PD patients, akin to B...

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Bibliographic Details
Main Authors: Gemma Gomez‐Giro, Daniela Frangenberg, Daniela Vega, Alise Zagare, Kyriaki Barmpa, Paul M. A. Antony, Graham Robertson, Rahman Sabahi‐Kaviani, Kristian Haendler, Nathalie Kruse, Florentia Papastefanaki, Rebecca Matsas, Malte Spielmann, Regina Luttge, Jens C. Schwamborn
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Advanced Science
Subjects:
α‐synuclein
brain organoid
in vitro disease modeling
Parkinson's disease
Online Access:https://doi.org/10.1002/advs.202409040
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