Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population
Aim. To investigate whether HLA class I polymorphisms could influence the clearance of hepatitis B surface antigen (HBsAg) in Qidong Han population. Methods. We genotyped HLA-A, -B, and -C loci of 448 individuals with HBV persistent infection and 140 persons with spontaneous clearance of HBsAg by po...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/145725 |
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| author | Fengqin Miao Hang Sun Ning Pan Jinhuan Xu Jie Qiu Yuqing Shen Wei Xie Jianqiong Zhang |
| author_facet | Fengqin Miao Hang Sun Ning Pan Jinhuan Xu Jie Qiu Yuqing Shen Wei Xie Jianqiong Zhang |
| author_sort | Fengqin Miao |
| collection | DOAJ |
| description | Aim. To investigate whether HLA class I polymorphisms could influence the clearance of hepatitis B surface antigen (HBsAg) in Qidong Han population. Methods. We genotyped HLA-A, -B, and -C loci of 448 individuals with HBV persistent infection and 140 persons with spontaneous clearance of HBsAg by polymerase chain reaction with sequencing based typing (PCR/SBT). All the individuals were unrelated males enrolled from Qidong Han population and were followed up for 10 years. Results. The frequency of HLA-A*33:03:01G was increased in persistent HBV infection group (P value is 0.028), while frequency of HLA-B*13:01:01G was increased in HBsAg clearance group (P value is 0.0004). Conclusion. These findings suggested that the host HLA class I polymorphism is an important factor in determining the outcomes of HBV infection. |
| format | Article |
| id | doaj-art-ff028766dcd34dc3b3969a33acb281c7 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-ff028766dcd34dc3b3969a33acb281c72025-02-03T01:13:02ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/145725145725Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han PopulationFengqin Miao0Hang Sun1Ning Pan2Jinhuan Xu3Jie Qiu4Yuqing Shen5Wei Xie6Jianqiong Zhang7Medical School, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, ChinaKey Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210096, ChinaMedical School, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, ChinaKey Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210096, ChinaKey Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210096, ChinaMedical School, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, ChinaKey Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210096, ChinaMedical School, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, ChinaAim. To investigate whether HLA class I polymorphisms could influence the clearance of hepatitis B surface antigen (HBsAg) in Qidong Han population. Methods. We genotyped HLA-A, -B, and -C loci of 448 individuals with HBV persistent infection and 140 persons with spontaneous clearance of HBsAg by polymerase chain reaction with sequencing based typing (PCR/SBT). All the individuals were unrelated males enrolled from Qidong Han population and were followed up for 10 years. Results. The frequency of HLA-A*33:03:01G was increased in persistent HBV infection group (P value is 0.028), while frequency of HLA-B*13:01:01G was increased in HBsAg clearance group (P value is 0.0004). Conclusion. These findings suggested that the host HLA class I polymorphism is an important factor in determining the outcomes of HBV infection.http://dx.doi.org/10.1155/2013/145725 |
| spellingShingle | Fengqin Miao Hang Sun Ning Pan Jinhuan Xu Jie Qiu Yuqing Shen Wei Xie Jianqiong Zhang Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population Clinical and Developmental Immunology |
| title | Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population |
| title_full | Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population |
| title_fullStr | Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population |
| title_full_unstemmed | Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population |
| title_short | Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population |
| title_sort | association of human leukocyte antigen class i polymorphism with spontaneous clearance of hepatitis b surface antigen in qidong han population |
| url | http://dx.doi.org/10.1155/2013/145725 |
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