Comparative Assessment of Serum Prostate Specific Antigen (PSA) and Inosine Monophosphate Dehydrogenase-2 (IMPDH-2) as Predictors of Aggressive Prostate Cancer
Background: This study was aimed at comparing serum Prostate Specific Antigen and Inosine Monophosphate Dehydrogenase-2 in predicting aggressive prostate cancer by determining their correlations with Gleason score and International Society of Urologic Pathologists grade groups. Methods: This was...
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University Library System, University of Pittsburgh
2025-05-01
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| Series: | International Journal of Medical Students |
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| Online Access: | http://ijms.info/IJMS/article/view/2767 |
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| author | Ahmed Mohammed Umar Ismaila Arzika Mungadi Ngwobia Peter Agwu Abdulwahab-Ahmed Abdullah Abubakar Sadiq Muhammad Khalid Abdullahi Emmanuel Ugbede Oyibo |
| author_facet | Ahmed Mohammed Umar Ismaila Arzika Mungadi Ngwobia Peter Agwu Abdulwahab-Ahmed Abdullah Abubakar Sadiq Muhammad Khalid Abdullahi Emmanuel Ugbede Oyibo |
| author_sort | Ahmed Mohammed Umar |
| collection | DOAJ |
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Background: This study was aimed at comparing serum Prostate Specific Antigen and Inosine Monophosphate Dehydrogenase-2 in predicting aggressive prostate cancer by determining their correlations with Gleason score and International Society of Urologic Pathologists grade groups.
Methods: This was a hospital-based quantitative descriptive cross-sectional study. Sixty-three prostate adenocarcinoma patients were recruited and their serum was assayed for IMPDH-2 and PSA. Correlations of serum IMPDH-2 and PSA with Gleason score and ISUP Grade Groups were determined using Spearman’s rho and Kendall tau correlation coefficients, respectively. The correlation (r) was graded as very weak when r (< 0.3), weak (0.3 – 0.4), moderate (0.5 – 0.6), or strong (≥ 0.7). The magnitude of the correlation was assessed by calculating the coefficient of determination for the respective analysis (R2). Levels of statistical significance were set as p < 0.05.
Results: The mean age was 68.6 years. The mean serum IMPDH-2 and PSA were 76.2pg/ml and 65.9ng/ml respectively. Serum IMPDH-2 did not correlate with Gleason score (r = 0.08, p = 0.55) or ISUP Grade groups (τ = 0.03, p = 0.79). Serum PSA correlated weakly with Gleason score (r = 0.30, p = 0.02) and very weakly with ISUP Grade groups (τ = 0.21, p = 0.04). The magnitude of correlation was 0.101. PSA did not significantly outperform IMPDH-2 in predicting the Gleason score (p = 0.53).
Conclusion: Neither serum IMPDH-2 nor PSA have sufficient accuracy in predicting Gleason score and ISUP Grade groups. None is a good predictor of aggressive prostate cancer.
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| format | Article |
| id | doaj-art-fefee4fff1404ccd9627dde1f503d3ce |
| institution | OA Journals |
| issn | 2076-6327 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | University Library System, University of Pittsburgh |
| record_format | Article |
| series | International Journal of Medical Students |
| spelling | doaj-art-fefee4fff1404ccd9627dde1f503d3ce2025-08-20T01:49:26ZengUniversity Library System, University of PittsburghInternational Journal of Medical Students2076-63272025-05-01Comparative Assessment of Serum Prostate Specific Antigen (PSA) and Inosine Monophosphate Dehydrogenase-2 (IMPDH-2) as Predictors of Aggressive Prostate CancerAhmed Mohammed Umar0Ismaila Arzika Mungadi1Ngwobia Peter Agwu2Abdulwahab-Ahmed Abdullah3Abubakar Sadiq Muhammad4Khalid Abdullahi5Emmanuel Ugbede Oyibo6TetFund Center of Excellence in Urology and Nephrology, Institute of Urology and Nephrology, Usmanu Danfodiyo University and Teaching Hospital SokotoTetFund Center of Excellence in Urology and Nephrology, Institute of Urology and Nephrology, Usmanu Danfodiyo University Teaching Hospital SokotoTetFund Center of Excellence in Urology and Nephrology, Institute of Urology and Nephrology, Usmanu Danfodiyo University Teaching Hospital SokotoTetFund Center of Excellence in Urology and Nephrology, Institute of Urology and Nephrology, Usmanu Danfodiyo University Teaching Hospital SokotoTetFund Center of Excellence in Urology and Nephrology, Institute of Urology and Nephrology, Usmanu Danfodiyo University Teaching Hospital SokotoTetFund Center of Excellence in Urology and Nephrology, Institute of Urology and Nephrology, Usmanu Danfodiyo University Teaching Hospital SokotoFederal Medical Center Keffi, Nasarawa State, Nigeria Background: This study was aimed at comparing serum Prostate Specific Antigen and Inosine Monophosphate Dehydrogenase-2 in predicting aggressive prostate cancer by determining their correlations with Gleason score and International Society of Urologic Pathologists grade groups. Methods: This was a hospital-based quantitative descriptive cross-sectional study. Sixty-three prostate adenocarcinoma patients were recruited and their serum was assayed for IMPDH-2 and PSA. Correlations of serum IMPDH-2 and PSA with Gleason score and ISUP Grade Groups were determined using Spearman’s rho and Kendall tau correlation coefficients, respectively. The correlation (r) was graded as very weak when r (< 0.3), weak (0.3 – 0.4), moderate (0.5 – 0.6), or strong (≥ 0.7). The magnitude of the correlation was assessed by calculating the coefficient of determination for the respective analysis (R2). Levels of statistical significance were set as p < 0.05. Results: The mean age was 68.6 years. The mean serum IMPDH-2 and PSA were 76.2pg/ml and 65.9ng/ml respectively. Serum IMPDH-2 did not correlate with Gleason score (r = 0.08, p = 0.55) or ISUP Grade groups (τ = 0.03, p = 0.79). Serum PSA correlated weakly with Gleason score (r = 0.30, p = 0.02) and very weakly with ISUP Grade groups (τ = 0.21, p = 0.04). The magnitude of correlation was 0.101. PSA did not significantly outperform IMPDH-2 in predicting the Gleason score (p = 0.53). Conclusion: Neither serum IMPDH-2 nor PSA have sufficient accuracy in predicting Gleason score and ISUP Grade groups. None is a good predictor of aggressive prostate cancer. http://ijms.info/IJMS/article/view/2767Gleason ScoreInosine Monophosphate Dehydrogenase-2ISUP Grade GroupProstate CancerProstate Specific Antigen |
| spellingShingle | Ahmed Mohammed Umar Ismaila Arzika Mungadi Ngwobia Peter Agwu Abdulwahab-Ahmed Abdullah Abubakar Sadiq Muhammad Khalid Abdullahi Emmanuel Ugbede Oyibo Comparative Assessment of Serum Prostate Specific Antigen (PSA) and Inosine Monophosphate Dehydrogenase-2 (IMPDH-2) as Predictors of Aggressive Prostate Cancer International Journal of Medical Students Gleason Score Inosine Monophosphate Dehydrogenase-2 ISUP Grade Group Prostate Cancer Prostate Specific Antigen |
| title | Comparative Assessment of Serum Prostate Specific Antigen (PSA) and Inosine Monophosphate Dehydrogenase-2 (IMPDH-2) as Predictors of Aggressive Prostate Cancer |
| title_full | Comparative Assessment of Serum Prostate Specific Antigen (PSA) and Inosine Monophosphate Dehydrogenase-2 (IMPDH-2) as Predictors of Aggressive Prostate Cancer |
| title_fullStr | Comparative Assessment of Serum Prostate Specific Antigen (PSA) and Inosine Monophosphate Dehydrogenase-2 (IMPDH-2) as Predictors of Aggressive Prostate Cancer |
| title_full_unstemmed | Comparative Assessment of Serum Prostate Specific Antigen (PSA) and Inosine Monophosphate Dehydrogenase-2 (IMPDH-2) as Predictors of Aggressive Prostate Cancer |
| title_short | Comparative Assessment of Serum Prostate Specific Antigen (PSA) and Inosine Monophosphate Dehydrogenase-2 (IMPDH-2) as Predictors of Aggressive Prostate Cancer |
| title_sort | comparative assessment of serum prostate specific antigen psa and inosine monophosphate dehydrogenase 2 impdh 2 as predictors of aggressive prostate cancer |
| topic | Gleason Score Inosine Monophosphate Dehydrogenase-2 ISUP Grade Group Prostate Cancer Prostate Specific Antigen |
| url | http://ijms.info/IJMS/article/view/2767 |
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