Temporal control of self‐organized pattern formation without morphogen gradients in bacteria
Abstract Diverse mechanisms have been proposed to explain biological pattern formation. Regardless of their specific molecular interactions, the majority of these mechanisms require morphogen gradients as the spatial cue, which are either predefined or generated as a part of the patterning process....
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| Format: | Article |
| Language: | English |
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Springer Nature
2013-10-01
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| Series: | Molecular Systems Biology |
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| Online Access: | https://doi.org/10.1038/msb.2013.55 |
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| _version_ | 1849388694074556416 |
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| author | Stephen Payne Bochong Li Yangxiaolu Cao David Schaeffer Marc D Ryser Lingchong You |
| author_facet | Stephen Payne Bochong Li Yangxiaolu Cao David Schaeffer Marc D Ryser Lingchong You |
| author_sort | Stephen Payne |
| collection | DOAJ |
| description | Abstract Diverse mechanisms have been proposed to explain biological pattern formation. Regardless of their specific molecular interactions, the majority of these mechanisms require morphogen gradients as the spatial cue, which are either predefined or generated as a part of the patterning process. However, using Escherichia coli programmed by a synthetic gene circuit, we demonstrate here the generation of robust, self‐organized ring patterns of gene expression in the absence of an apparent morphogen gradient. Instead of being a spatial cue, the morphogen serves as a timing cue to trigger the formation and maintenance of the ring patterns. The timing mechanism enables the system to sense the domain size of the environment and generate patterns that scale accordingly. Our work defines a novel mechanism of pattern formation that has implications for understanding natural developmental processes. |
| format | Article |
| id | doaj-art-fefdd447797a43328e2af11b7faee319 |
| institution | Kabale University |
| issn | 1744-4292 |
| language | English |
| publishDate | 2013-10-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | Molecular Systems Biology |
| spelling | doaj-art-fefdd447797a43328e2af11b7faee3192025-08-20T03:42:11ZengSpringer NatureMolecular Systems Biology1744-42922013-10-019111010.1038/msb.2013.55Temporal control of self‐organized pattern formation without morphogen gradients in bacteriaStephen Payne0Bochong Li1Yangxiaolu Cao2David Schaeffer3Marc D Ryser4Lingchong You5Department of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityDepartment of Mathematics, Duke UniversityDepartment of Mathematics, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityAbstract Diverse mechanisms have been proposed to explain biological pattern formation. Regardless of their specific molecular interactions, the majority of these mechanisms require morphogen gradients as the spatial cue, which are either predefined or generated as a part of the patterning process. However, using Escherichia coli programmed by a synthetic gene circuit, we demonstrate here the generation of robust, self‐organized ring patterns of gene expression in the absence of an apparent morphogen gradient. Instead of being a spatial cue, the morphogen serves as a timing cue to trigger the formation and maintenance of the ring patterns. The timing mechanism enables the system to sense the domain size of the environment and generate patterns that scale accordingly. Our work defines a novel mechanism of pattern formation that has implications for understanding natural developmental processes.https://doi.org/10.1038/msb.2013.55morphogenpattern formationsynthetic biologysystems biologytemporal control |
| spellingShingle | Stephen Payne Bochong Li Yangxiaolu Cao David Schaeffer Marc D Ryser Lingchong You Temporal control of self‐organized pattern formation without morphogen gradients in bacteria Molecular Systems Biology morphogen pattern formation synthetic biology systems biology temporal control |
| title | Temporal control of self‐organized pattern formation without morphogen gradients in bacteria |
| title_full | Temporal control of self‐organized pattern formation without morphogen gradients in bacteria |
| title_fullStr | Temporal control of self‐organized pattern formation without morphogen gradients in bacteria |
| title_full_unstemmed | Temporal control of self‐organized pattern formation without morphogen gradients in bacteria |
| title_short | Temporal control of self‐organized pattern formation without morphogen gradients in bacteria |
| title_sort | temporal control of self organized pattern formation without morphogen gradients in bacteria |
| topic | morphogen pattern formation synthetic biology systems biology temporal control |
| url | https://doi.org/10.1038/msb.2013.55 |
| work_keys_str_mv | AT stephenpayne temporalcontrolofselforganizedpatternformationwithoutmorphogengradientsinbacteria AT bochongli temporalcontrolofselforganizedpatternformationwithoutmorphogengradientsinbacteria AT yangxiaolucao temporalcontrolofselforganizedpatternformationwithoutmorphogengradientsinbacteria AT davidschaeffer temporalcontrolofselforganizedpatternformationwithoutmorphogengradientsinbacteria AT marcdryser temporalcontrolofselforganizedpatternformationwithoutmorphogengradientsinbacteria AT lingchongyou temporalcontrolofselforganizedpatternformationwithoutmorphogengradientsinbacteria |