The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins.

The molecular assembly of amyloid aβ controls its neurotoxicity and binding to cellular proteins.

Accumulation of β-sheet-rich peptide (Aβ) is strongly associated with Alzheimer's disease, characterized by reduction in synapse density, structural alterations of dendritic spines, modification of synaptic protein expression, loss of long-term potentiation and neuronal cell death. Aβ species a...

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Main Authors: Claudia Manzoni, Laura Colombo, Paolo Bigini, Valentina Diana, Alfredo Cagnotto, Massimo Messa, Monica Lupi, Valentina Bonetto, Mauro Pignataro, Cristina Airoldi, Erika Sironi, Alun Williams, Mario Salmona
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024909&type=printable
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