Persistent alterations of cortical hemodynamic response in asymptomatic concussed patients
Aim: The underlying neurophysiological effects of concussion often result in attenuated cognitive and cortical function. To understand the relation between cognition and brain injury, we investigated the effects of concussion on attentional networks using functional near-infrared spectroscopy (fNIRS...
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| Format: | Article |
| Language: | English |
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Aldus Press
2021-03-01
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| Series: | Concussion |
| Subjects: | |
| Online Access: | https://www.futuremedicine.com/doi/10.2217/cnc-2020-0014 |
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| author | Allyssa K Memmini Xin Sun Xiaosu Hu Jessica Kim Noelle K Herzog Mohammed N Islam Daniel H Weissman Alexander J Rogers Ioulia Kovelman Steven P Broglio |
| author_facet | Allyssa K Memmini Xin Sun Xiaosu Hu Jessica Kim Noelle K Herzog Mohammed N Islam Daniel H Weissman Alexander J Rogers Ioulia Kovelman Steven P Broglio |
| author_sort | Allyssa K Memmini |
| collection | DOAJ |
| description | Aim: The underlying neurophysiological effects of concussion often result in attenuated cognitive and cortical function. To understand the relation between cognition and brain injury, we investigated the effects of concussion on attentional networks using functional near-infrared spectroscopy (fNIRS). Materials & methods: Healthy controls and concussed patients, tested within 72 h from injury (T1) and after symptoms resolved (T2) completed a computerized attention task during fNIRS imaging. Results: T1 patients exhibited slower reaction times and reduced brain activation pattern relative to healthy controls. Interestingly, the cortical oxygenation hemoglobin response at T2 was greater relative to T1 and healthy controls, while reaction time was normative. Conclusion: The exploratory findings of this study suggest once asymptomatic, a compensatory hemodynamic response may support the restoration of reaction time despite ongoing physiological recovery. |
| format | Article |
| id | doaj-art-fef0dc25dbbc4e4f81769c28b0739e0e |
| institution | OA Journals |
| issn | 2056-3299 |
| language | English |
| publishDate | 2021-03-01 |
| publisher | Aldus Press |
| record_format | Article |
| series | Concussion |
| spelling | doaj-art-fef0dc25dbbc4e4f81769c28b0739e0e2025-08-20T02:04:49ZengAldus PressConcussion2056-32992021-03-016110.2217/cnc-2020-0014Persistent alterations of cortical hemodynamic response in asymptomatic concussed patientsAllyssa K Memmini0Xin Sun1Xiaosu Hu2Jessica Kim3Noelle K Herzog4Mohammed N Islam5Daniel H Weissman6Alexander J Rogers7Ioulia Kovelman8Steven P Broglio91Michigan Concussion Center, University of Michigan, Ann Arbor, MI 48109, USA2Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA3School of Dentistry, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan, Ann Arbor, MI 48109, USA2Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA5Department of Psychology, University of Toledo, Toledo, OH 43606, USA6Department of Electrical and Computer Engineering, University of Michigan, Ann Arbor, Michigan MI 48109, USA2Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA1Michigan Concussion Center, University of Michigan, Ann Arbor, MI 48109, USA2Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA1Michigan Concussion Center, University of Michigan, Ann Arbor, MI 48109, USAAim: The underlying neurophysiological effects of concussion often result in attenuated cognitive and cortical function. To understand the relation between cognition and brain injury, we investigated the effects of concussion on attentional networks using functional near-infrared spectroscopy (fNIRS). Materials & methods: Healthy controls and concussed patients, tested within 72 h from injury (T1) and after symptoms resolved (T2) completed a computerized attention task during fNIRS imaging. Results: T1 patients exhibited slower reaction times and reduced brain activation pattern relative to healthy controls. Interestingly, the cortical oxygenation hemoglobin response at T2 was greater relative to T1 and healthy controls, while reaction time was normative. Conclusion: The exploratory findings of this study suggest once asymptomatic, a compensatory hemodynamic response may support the restoration of reaction time despite ongoing physiological recovery.https://www.futuremedicine.com/doi/10.2217/cnc-2020-0014attention taskmild traumatic brain injuryneuroimagingreaction timerecovery |
| spellingShingle | Allyssa K Memmini Xin Sun Xiaosu Hu Jessica Kim Noelle K Herzog Mohammed N Islam Daniel H Weissman Alexander J Rogers Ioulia Kovelman Steven P Broglio Persistent alterations of cortical hemodynamic response in asymptomatic concussed patients Concussion attention task mild traumatic brain injury neuroimaging reaction time recovery |
| title | Persistent alterations of cortical hemodynamic response in asymptomatic concussed patients |
| title_full | Persistent alterations of cortical hemodynamic response in asymptomatic concussed patients |
| title_fullStr | Persistent alterations of cortical hemodynamic response in asymptomatic concussed patients |
| title_full_unstemmed | Persistent alterations of cortical hemodynamic response in asymptomatic concussed patients |
| title_short | Persistent alterations of cortical hemodynamic response in asymptomatic concussed patients |
| title_sort | persistent alterations of cortical hemodynamic response in asymptomatic concussed patients |
| topic | attention task mild traumatic brain injury neuroimaging reaction time recovery |
| url | https://www.futuremedicine.com/doi/10.2217/cnc-2020-0014 |
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